The incidence,disability and mortality of nervous system diseases have risen sharply worldwide.At present,the pathogenesis and mechanism of nervous system diseases have not been clarified.Tongqiao Huoxue Decoction in Yi Lin Gai Cuo has the effects of promoting blood circulation and removing blood stasis,dredging orifices and activating collaterals.This article reviewed the clinical trials and basic research of Tongluo Huoxue Decoction and its modified prescriptions in the treatment of neurological diseases in recent years.It showed that this prescription is often used in the treatment of blood stasis syndrome at the brain orifices,which has a significant effect on improving brain function and treating a variety of intractable diseases related to brain nerves;its pharmacological mechanisms involve regulating neurotransmitters,restoring nerve function,inhibiting oxidative stress along with inflammatory responses,optimizing hemodynamics and blood rheology retarding vascular remodeling,and promoting angiogenesis.

The incidence,disability and mortality of nervous system diseases have risen sharply worldwide.At present,the pathogenesis and mechanism of nervous system diseases have not been clarified.Tongqiao Huoxue Decoction in Yi Lin Gai Cuo has the effects of promoting blood circulation and removing blood stasis,dredging orifices and activating collaterals.This article reviewed the clinical trials and basic research of Tongluo Huoxue Decoction and its modified prescriptions in the treatment of neurological diseases in recent years.It showed that this prescription is often used in the treatment of blood stasis syndrome at the brain orifices,which has a significant effect on improving brain function and treating a variety of intractable diseases related to brain nerves;its pharmacological mechanisms involve regulating neurotransmitters,restoring nerve function,inhibiting oxidative stress along with inflammatory responses,optimizing hemodynamics and blood rheology retarding vascular remodeling,and promoting angiogenesis.

Objective:To investigate the current situation and influencing factors of clinical nurses'clinical decision-making ability,and provide a reference and evidence for improving and enhancing the correct clinical decision-making ability of clinical nurses.Methods:A total of 300 clinical nurses in Shaanxi Province were selected as the research subjects by using the convenience sampling method.The General Information Questionnaire,Clinical Decision-Making Scale,and Comprehensive Decision-Making Style Scale were used to conduct the investigation and study.The influencing factors of clinical nurses'clinical decision-making ability were analyzed by using single-factor analysis and multivariate linear regression.Results:The total score of clinical nurses'clinical decision-making ability was(163.85±13.78)points,reaching the high-level standard of clinical decision-making ability(146.68-200.00)points.The results of Spearman rank correlation analysis showed that there was a significant positive correlation between the total score and the score of each dimension of clinical decision-making ability and the score of rational decision-making style(P<0.05).The score of the dimension of searching for information or new information was only negatively correlated with the score of intuitive-impulsive decision-making style(P<0.05).Avoidant decision-making style was negatively correlated with the scores of seeking information or new information,clarifying goals and values,the total score of clinical decision-making ability,and the dimensions of finding alternative solutions(P<0.05).The results of multiple linear regression showed that rational decision-making style can positively affect clinical nurses'clinical decision-making ability,while avoidance decision-making style can negatively affect it.Conclusion:The clinical nurses'clinical decision-making ability has been maintained at a relatively constant high level,and it is greatly influenced by rational and avoidant decision-making styles.Medical managers need to organize targeted training activities and other measures to promote the construction of clinical nurses'rational decision-making style and minimize the influence of avoidant decision-making style,thus improving the clinical nurses'clinical decision-making ability.

Objective:To gain a deep understanding of the supportive care needs of families of children with retinoblastoma (RB) through qualitative research.Methods:From March to May 2022, a semi-structured interview was conducted using purposive sampling to select the family members of 15 RB children in the Department of Eye Tumor of Beijing Tongren Hospital affiliated to Capital Medical University. Colaizzi 7-step analysis method was used to refine, extract, and analyze interview data.Results:The supportive care needs of the families of RB children were summarized into three themes and six sub-themes, namely, psychological needs (emotional listening and psychological support), knowledge needs (disease knowledge needs, children's post discharge guidance, internet resource needs), and economic needs (social resource integration) .Conclusions:RB, as a malignant eye tumor, often brings a heavy burden to families. Family members of children generally experience negative emotions such as anxiety and depression, as well as a lack of knowledge. The economic burden on families is heavy, and there is a high demand for supportive care. The supportive care program for families of RB children is not yet perfect, and nurses should provide emotional support and professional assistance to the families, providing help and guidance in psychological counseling, knowledge needs, economic assistance, and other aspects.

Objective To test the inhibitory effect of Corynebacterium cell wall extract on bladder cancer cells. Methods The bladder RNA was extracted from bladder cancer rats, and concentration and purity of RNA was detected. The extracted RNA was reversely transcribed into cDNA, then the primers were designed and the Grim19 gene, β-actin gene, Stat3 gene was amplified. Finaly the PCR product was subjected to agarose gel electrophoresis. Results OD260 was 0.07, and OD260/OD280 was 2.03 in the group of Corynebacterium parvm extract(3-5# ); OD260 was 0.12, and OD260/OD280 was 2.07 in the group of MNU( 6-5#);OD260 was 0.08, and OD260/OD280 was 2.07 in the group of physiological saline(7-5#) . The results of agarose gelelectrophoresis showed that Grim19 gene and Stat3 gene was expressed highly in the bladder of rats from the group of CP cell wall extract (3-5# ). Grim19 gene was expressed lowly, while Stat3 gene was expressed highly in the bladder of rats from the group of MNU (6-5#). Grim19 gene and Stat3 gene was expressed normally in the bladder of rats from physiological saline(7-5). Conclusions The expression situation of antitumor gene Grim19 and tumor gene Stat3 in the bladder of rats was inhibited by the cell wall extract of Corynebacterium parvm, which indicates that the cell wall extract of Corynebacterium parvm has inhibitory effect on bladder cancer cells.

Objective To investigate the change in mortality of congenital malformation in children aged ＜5 years in Beijing from 2006 to 2015.Methods Using the death surveillance data in children aged ＜5 years in Beijing from 2006 to 2015,which was collected from the real-time surveillance network,we calculated the area and age distributions of the mortality of congenital malformation in children aged ＜5 years in Beijing.Meanwhile,the variations of age,time and space in the causes of deaths were discussed.Results The mortality rate of congenital malformation in the children s decreased from 1.909‰ in 2006 to 0.703‰ in 2015,the decrease rate was 63.17％.The decrease rate was highest in neonates (71.50％) (x2=57.993,P＜0.01).Expect urban area (x2=3.384,P＞0.05),the mortality rates of congenital malformation in the children showed a downward trend in outer suburban area and suburban area (x2=40.637 and 50.646,P＜0.01).The proportion of the children died of congenital malformation decreased from 32.97％ in 2006 to 23.24％ in 2015,which mainly occurred in infancy and neonatal period (x2=9.395 and 4.354,P＜0.05).The constituent ratios of the children died of neural tube defects,respiratory system abnormalities and other abnormalities decreased significantly (x2=13.478,7.358,7.912 and 10.074,P＜0.01).The constituent ratios of children died of chromosomal abnormality,multiple malformations and digestive tract abnormality didn't decreased significantly (P＞0.05).In the leading causes of deaths from congenital malformation,the mortality of congenital heart disease,neural tube defects and digestive tract atresia decreased obviously (x2=70.868,18.431 and 9.225,P＜0.01),except biliary atresia (x2=1.407,P＞ 0.05).There was an obvious area specific difference between the deaths of congenital heart disease and the deaths of neural tube defects,the mortality was higher in outer suburbs than in suburban and urban area (x2=45.783 and 6.649,P＜0.05).Conclusion Although the mortality rate of children with congenital malformation in Beijing has declined year by year,it is still the main cause of deaths in children under 5 years old,and the prevention and control of related diseases should be strengthened.

Objective To explore the effects of nursing intervention based on health belief model (HBM) in improving compliance of screen by gastroscope in high risk group of gastric cancer so as to provide theoretical bases for clinical nursing activity.Methods High risk group of gastric cancer with preliminary screening without completing gastroscopy from five communities of Yanta District, Beilin District, Lianhu District of Xi'an City were selected by convenience sampling from 20th March 2015 to 15th December 2016. They were divided into observation group (n=500, conventional education on screening of gastric cancer) and control group (n=500, nursing intervention based on HBM for one year) with the method of random number table. And then, the cognition, score of health belief and the screening rate of gastroscope of both groups were compared. Results After intervention, the scores of all dimensions on cognition about gastric cancer in observation group were higher than those in control group with significant differences (P<0.05). There were statistically significant differences in scores of all dimensions on cognition about gastric cancer before and after intervention in observation group (P<0.05), while there was no statistically significant differences in those in control group (P>0.05). There were also statistically significant differences in scores of all dimensions of health belief between two groups (P<0.05). Compared within groups, there was no statistically significant differences in scores of all dimensions of health belief except for self efficacy in control group before and after intervention (P>0.05), while there were statistical significances in scores of all dimensions in observation group (P<0.05). After intervention, the screening rate of gastroscope in observation group was significantly higher than that in control group (P<0.05).Conclusions The nursing intervention based on HBM helps high risk group of gastric cancer sets up health belief, improves the participation rate of screening by gastroscope along with having important significance for the discovery rate of early gastric cancer.