Purpose: This study investigated the mediating effect of grit in the relationship between silence behavior and medication safety competence among nurses. Methods: The study included 166 nurses from four university hospitals and general hospitals in Seoul and Gyeonggi-do, South Korea. Data were collected from March 1 to 10, 2024, using self-report questionnaires. Data were analyzed using the t-test, analysis of variance, Scheffé’s test, and Pearson’s correlation coefficients with IBM SPSS Statistics ver. 23.0 (IBM Corp.). A mediation analysis was performed using Hayes’s PROCESS macro model 4 and the bootstrapping method. Results: Medication safety competence showed significant correlations with silence behavior (r=–.21, p=.008) and grit (r=.43, p<.001). Furthermore, grit partially mediated the relationship between silence behavior and medication safety competence. Conclusion This study indicates that grit is a significant mediator in the relationship between silence behavior and medication safety competence. Therefore, an integrated approach that reduces silence behavior and promotes grit is essential for strengthening nurses’ medication safety competence. Ultimately, these strategies will help ensure patient safety by improving medication safety competence.

Purpose: To identify influencing factors of media literacy, perceived neighborhood disorder, and adult attachment styles on fear of crime in adults in their 30s. Methods: Subjects were 232 adults in their 30s residing in South Korea. Data were collected through online and mobile surveys from February 21 to 26, 2024. Results: The following factors were found to significantly influence general fear of crime: female (β=.29, p<.001), perceived neighborhood disorder (β=.22, p=.002), attachment anxiety (β=.19, p=.003), and exclusion harmful media (β=.14, p=.020). These factors explained 23% of general fear of crime in adults in their 30s. The following factors significantly influenced specific fear of crime: perceived neighborhood disorder (β=.33, p<.001), attachment anxiety (β=.29, p<.001), female (β=.17, p=.003) and daily video platform usage (β=.16, p=.045). These factors explained 32% of specific fear of crime in adults in their 30s. Conclusion A multidimensional approach to understanding influencing factors of fear of crime is necessary because such an approach can serve as a basis for future public safety policies. Community mental health nurses should also increase their focus on ensuring that citizens feel safe in their communities.

Purpose: This study investigated the mediating effect of grit in the relationship between silence behavior and medication safety competence among nurses. Methods: The study included 166 nurses from four university hospitals and general hospitals in Seoul and Gyeonggi-do, South Korea. Data were collected from March 1 to 10, 2024, using self-report questionnaires. Data were analyzed using the t-test, analysis of variance, Scheffé’s test, and Pearson’s correlation coefficients with IBM SPSS Statistics ver. 23.0 (IBM Corp.). A mediation analysis was performed using Hayes’s PROCESS macro model 4 and the bootstrapping method. Results: Medication safety competence showed significant correlations with silence behavior (r=–.21, p=.008) and grit (r=.43, p<.001). Furthermore, grit partially mediated the relationship between silence behavior and medication safety competence. Conclusion This study indicates that grit is a significant mediator in the relationship between silence behavior and medication safety competence. Therefore, an integrated approach that reduces silence behavior and promotes grit is essential for strengthening nurses’ medication safety competence. Ultimately, these strategies will help ensure patient safety by improving medication safety competence.

Purpose: To identify influencing factors of media literacy, perceived neighborhood disorder, and adult attachment styles on fear of crime in adults in their 30s. Methods: Subjects were 232 adults in their 30s residing in South Korea. Data were collected through online and mobile surveys from February 21 to 26, 2024. Results: The following factors were found to significantly influence general fear of crime: female (β=.29, p<.001), perceived neighborhood disorder (β=.22, p=.002), attachment anxiety (β=.19, p=.003), and exclusion harmful media (β=.14, p=.020). These factors explained 23% of general fear of crime in adults in their 30s. The following factors significantly influenced specific fear of crime: perceived neighborhood disorder (β=.33, p<.001), attachment anxiety (β=.29, p<.001), female (β=.17, p=.003) and daily video platform usage (β=.16, p=.045). These factors explained 32% of specific fear of crime in adults in their 30s. Conclusion A multidimensional approach to understanding influencing factors of fear of crime is necessary because such an approach can serve as a basis for future public safety policies. Community mental health nurses should also increase their focus on ensuring that citizens feel safe in their communities.

Purpose: This study investigated the mediating effect of grit in the relationship between silence behavior and medication safety competence among nurses. Methods: The study included 166 nurses from four university hospitals and general hospitals in Seoul and Gyeonggi-do, South Korea. Data were collected from March 1 to 10, 2024, using self-report questionnaires. Data were analyzed using the t-test, analysis of variance, Scheffé’s test, and Pearson’s correlation coefficients with IBM SPSS Statistics ver. 23.0 (IBM Corp.). A mediation analysis was performed using Hayes’s PROCESS macro model 4 and the bootstrapping method. Results: Medication safety competence showed significant correlations with silence behavior (r=–.21, p=.008) and grit (r=.43, p<.001). Furthermore, grit partially mediated the relationship between silence behavior and medication safety competence. Conclusion This study indicates that grit is a significant mediator in the relationship between silence behavior and medication safety competence. Therefore, an integrated approach that reduces silence behavior and promotes grit is essential for strengthening nurses’ medication safety competence. Ultimately, these strategies will help ensure patient safety by improving medication safety competence.

Purpose: To identify influencing factors of media literacy, perceived neighborhood disorder, and adult attachment styles on fear of crime in adults in their 30s. Methods: Subjects were 232 adults in their 30s residing in South Korea. Data were collected through online and mobile surveys from February 21 to 26, 2024. Results: The following factors were found to significantly influence general fear of crime: female (β=.29, p<.001), perceived neighborhood disorder (β=.22, p=.002), attachment anxiety (β=.19, p=.003), and exclusion harmful media (β=.14, p=.020). These factors explained 23% of general fear of crime in adults in their 30s. The following factors significantly influenced specific fear of crime: perceived neighborhood disorder (β=.33, p<.001), attachment anxiety (β=.29, p<.001), female (β=.17, p=.003) and daily video platform usage (β=.16, p=.045). These factors explained 32% of specific fear of crime in adults in their 30s. Conclusion A multidimensional approach to understanding influencing factors of fear of crime is necessary because such an approach can serve as a basis for future public safety policies. Community mental health nurses should also increase their focus on ensuring that citizens feel safe in their communities.

Purpose: This study investigated the mediating effect of grit in the relationship between silence behavior and medication safety competence among nurses. Methods: The study included 166 nurses from four university hospitals and general hospitals in Seoul and Gyeonggi-do, South Korea. Data were collected from March 1 to 10, 2024, using self-report questionnaires. Data were analyzed using the t-test, analysis of variance, Scheffé’s test, and Pearson’s correlation coefficients with IBM SPSS Statistics ver. 23.0 (IBM Corp.). A mediation analysis was performed using Hayes’s PROCESS macro model 4 and the bootstrapping method. Results: Medication safety competence showed significant correlations with silence behavior (r=–.21, p=.008) and grit (r=.43, p<.001). Furthermore, grit partially mediated the relationship between silence behavior and medication safety competence. Conclusion This study indicates that grit is a significant mediator in the relationship between silence behavior and medication safety competence. Therefore, an integrated approach that reduces silence behavior and promotes grit is essential for strengthening nurses’ medication safety competence. Ultimately, these strategies will help ensure patient safety by improving medication safety competence.

Purpose: To identify influencing factors of media literacy, perceived neighborhood disorder, and adult attachment styles on fear of crime in adults in their 30s. Methods: Subjects were 232 adults in their 30s residing in South Korea. Data were collected through online and mobile surveys from February 21 to 26, 2024. Results: The following factors were found to significantly influence general fear of crime: female (β=.29, p<.001), perceived neighborhood disorder (β=.22, p=.002), attachment anxiety (β=.19, p=.003), and exclusion harmful media (β=.14, p=.020). These factors explained 23% of general fear of crime in adults in their 30s. The following factors significantly influenced specific fear of crime: perceived neighborhood disorder (β=.33, p<.001), attachment anxiety (β=.29, p<.001), female (β=.17, p=.003) and daily video platform usage (β=.16, p=.045). These factors explained 32% of specific fear of crime in adults in their 30s. Conclusion A multidimensional approach to understanding influencing factors of fear of crime is necessary because such an approach can serve as a basis for future public safety policies. Community mental health nurses should also increase their focus on ensuring that citizens feel safe in their communities.

This study investigated the molecular mechanism of phenotypic switching of vascular smooth muscle cells (VSMCs), which play a crucial role in vascular remodeling using 9H-Carbazol-3-yl 4-aminobenzoate (CAB). CAB significantly attenuated platelet-derived growth factor (PDGF)-induced VSMC proliferation and migration. CAB suppressed PDGF-induced STAT3 activation by directly binding to the SH2 domain of STAT3. Downregulation of STAT3 phosphorylation by CAB attenuated CIAPIN1/JAK2/STAT3 axis through a decrease in CIAPIN1 transcription. Furthermore, abrogated CIAPIN1 decreased KLF4-mediated VSMC dedifferentiation and increased CDKN1B-induced cell cycle arrest and MMP9 suppression. CAB inhibited intimal hyperplasia in injury-induced neointima animal models by inhibition of the CIAPIN1/JAK2/STAT3 axis. However, CIAPIN1 overexpression attenuated CAB-mediated suppression of VSMC proliferation, migration, phenotypic switching, and intimal hyperplasia. Our study clarified the molecular mechanism underlying STAT3 inhibition of VSMC phenotypic switching and vascular remodeling and identified novel active CAB. These findings demonstrated that STAT3 can be a major regulator to control CIAPIN1/JAK2/STAT3 axis that may be a therapeutic target for treating vascular proliferative diseases.

Metabolic abnormalities in the liver are closely associated with diverse metabolic diseases such as non-alcoholic fatty liver disease, type 2 diabetes, and obesity. The aim of this study was to evaluate the ameliorating effect of robinetin (RBN) on the significant pathogenic features of metabolic failure in the liver and to identify the underlying molecular mechanism. RBN significantly decreased triglyceride (TG) accumulation by downregulating lipogenesis-related transcription factors in AML-12 murine hepatocyte cell line. In addition, mice fed with Western diet (WD) containing 0.025% or 0.05% RBN showed reduced liver mass and lipid droplet size, as well as improved plasma insulin levels and homeostatic model assessment of insulin resistance (HOMA-IR) values.CD38 was identified as a target of RBN using the BioAssay database, and its expression was increased in OPA-treated AML-12 cells and liver tissues of WD-fed mice. Furthermore, RBN elicited these effects through its anti-histone acetyltransferase (HAT) activity. Computational simulation revealed that RBN can dock into the HAT domain pocket of p300, a histone acetyltransferase, which leads to the abrogation of its catalytic activity. Additionally, knock-down of p300 using siRNA reduced CD38 expression.The chromatin immunoprecipitation (ChIP) assay showed that p300 occupancy on the promoter region of CD38 was significantly decreased, and H3K9 acetylation levels were diminished in lipid-accumulated AML-12 cells treated with RBN. RBN improves the pathogenic features of metabolic failure by suppressing the p300–CD38 axis through its anti-HAT activity, which suggests that RBN can be used as a new phytoceutical candidate for preventing or improving this condition.