Purpose: This study investigated the mediating effect of grit in the relationship between silence behavior and medication safety competence among nurses. Methods: The study included 166 nurses from four university hospitals and general hospitals in Seoul and Gyeonggi-do, South Korea. Data were collected from March 1 to 10, 2024, using self-report questionnaires. Data were analyzed using the t-test, analysis of variance, Scheffé’s test, and Pearson’s correlation coefficients with IBM SPSS Statistics ver. 23.0 (IBM Corp.). A mediation analysis was performed using Hayes’s PROCESS macro model 4 and the bootstrapping method. Results: Medication safety competence showed significant correlations with silence behavior (r=–.21, p=.008) and grit (r=.43, p<.001). Furthermore, grit partially mediated the relationship between silence behavior and medication safety competence. Conclusion This study indicates that grit is a significant mediator in the relationship between silence behavior and medication safety competence. Therefore, an integrated approach that reduces silence behavior and promotes grit is essential for strengthening nurses’ medication safety competence. Ultimately, these strategies will help ensure patient safety by improving medication safety competence.

Purpose: To identify influencing factors of media literacy, perceived neighborhood disorder, and adult attachment styles on fear of crime in adults in their 30s. Methods: Subjects were 232 adults in their 30s residing in South Korea. Data were collected through online and mobile surveys from February 21 to 26, 2024. Results: The following factors were found to significantly influence general fear of crime: female (β=.29, p<.001), perceived neighborhood disorder (β=.22, p=.002), attachment anxiety (β=.19, p=.003), and exclusion harmful media (β=.14, p=.020). These factors explained 23% of general fear of crime in adults in their 30s. The following factors significantly influenced specific fear of crime: perceived neighborhood disorder (β=.33, p<.001), attachment anxiety (β=.29, p<.001), female (β=.17, p=.003) and daily video platform usage (β=.16, p=.045). These factors explained 32% of specific fear of crime in adults in their 30s. Conclusion A multidimensional approach to understanding influencing factors of fear of crime is necessary because such an approach can serve as a basis for future public safety policies. Community mental health nurses should also increase their focus on ensuring that citizens feel safe in their communities.

Purpose: This study investigated the mediating effect of grit in the relationship between silence behavior and medication safety competence among nurses. Methods: The study included 166 nurses from four university hospitals and general hospitals in Seoul and Gyeonggi-do, South Korea. Data were collected from March 1 to 10, 2024, using self-report questionnaires. Data were analyzed using the t-test, analysis of variance, Scheffé’s test, and Pearson’s correlation coefficients with IBM SPSS Statistics ver. 23.0 (IBM Corp.). A mediation analysis was performed using Hayes’s PROCESS macro model 4 and the bootstrapping method. Results: Medication safety competence showed significant correlations with silence behavior (r=–.21, p=.008) and grit (r=.43, p<.001). Furthermore, grit partially mediated the relationship between silence behavior and medication safety competence. Conclusion This study indicates that grit is a significant mediator in the relationship between silence behavior and medication safety competence. Therefore, an integrated approach that reduces silence behavior and promotes grit is essential for strengthening nurses’ medication safety competence. Ultimately, these strategies will help ensure patient safety by improving medication safety competence.

Purpose: To identify influencing factors of media literacy, perceived neighborhood disorder, and adult attachment styles on fear of crime in adults in their 30s. Methods: Subjects were 232 adults in their 30s residing in South Korea. Data were collected through online and mobile surveys from February 21 to 26, 2024. Results: The following factors were found to significantly influence general fear of crime: female (β=.29, p<.001), perceived neighborhood disorder (β=.22, p=.002), attachment anxiety (β=.19, p=.003), and exclusion harmful media (β=.14, p=.020). These factors explained 23% of general fear of crime in adults in their 30s. The following factors significantly influenced specific fear of crime: perceived neighborhood disorder (β=.33, p<.001), attachment anxiety (β=.29, p<.001), female (β=.17, p=.003) and daily video platform usage (β=.16, p=.045). These factors explained 32% of specific fear of crime in adults in their 30s. Conclusion A multidimensional approach to understanding influencing factors of fear of crime is necessary because such an approach can serve as a basis for future public safety policies. Community mental health nurses should also increase their focus on ensuring that citizens feel safe in their communities.

Purpose: This study investigated the mediating effect of grit in the relationship between silence behavior and medication safety competence among nurses. Methods: The study included 166 nurses from four university hospitals and general hospitals in Seoul and Gyeonggi-do, South Korea. Data were collected from March 1 to 10, 2024, using self-report questionnaires. Data were analyzed using the t-test, analysis of variance, Scheffé’s test, and Pearson’s correlation coefficients with IBM SPSS Statistics ver. 23.0 (IBM Corp.). A mediation analysis was performed using Hayes’s PROCESS macro model 4 and the bootstrapping method. Results: Medication safety competence showed significant correlations with silence behavior (r=–.21, p=.008) and grit (r=.43, p<.001). Furthermore, grit partially mediated the relationship between silence behavior and medication safety competence. Conclusion This study indicates that grit is a significant mediator in the relationship between silence behavior and medication safety competence. Therefore, an integrated approach that reduces silence behavior and promotes grit is essential for strengthening nurses’ medication safety competence. Ultimately, these strategies will help ensure patient safety by improving medication safety competence.

Purpose: To identify influencing factors of media literacy, perceived neighborhood disorder, and adult attachment styles on fear of crime in adults in their 30s. Methods: Subjects were 232 adults in their 30s residing in South Korea. Data were collected through online and mobile surveys from February 21 to 26, 2024. Results: The following factors were found to significantly influence general fear of crime: female (β=.29, p<.001), perceived neighborhood disorder (β=.22, p=.002), attachment anxiety (β=.19, p=.003), and exclusion harmful media (β=.14, p=.020). These factors explained 23% of general fear of crime in adults in their 30s. The following factors significantly influenced specific fear of crime: perceived neighborhood disorder (β=.33, p<.001), attachment anxiety (β=.29, p<.001), female (β=.17, p=.003) and daily video platform usage (β=.16, p=.045). These factors explained 32% of specific fear of crime in adults in their 30s. Conclusion A multidimensional approach to understanding influencing factors of fear of crime is necessary because such an approach can serve as a basis for future public safety policies. Community mental health nurses should also increase their focus on ensuring that citizens feel safe in their communities.

Purpose: This study investigated the mediating effect of grit in the relationship between silence behavior and medication safety competence among nurses. Methods: The study included 166 nurses from four university hospitals and general hospitals in Seoul and Gyeonggi-do, South Korea. Data were collected from March 1 to 10, 2024, using self-report questionnaires. Data were analyzed using the t-test, analysis of variance, Scheffé’s test, and Pearson’s correlation coefficients with IBM SPSS Statistics ver. 23.0 (IBM Corp.). A mediation analysis was performed using Hayes’s PROCESS macro model 4 and the bootstrapping method. Results: Medication safety competence showed significant correlations with silence behavior (r=–.21, p=.008) and grit (r=.43, p<.001). Furthermore, grit partially mediated the relationship between silence behavior and medication safety competence. Conclusion This study indicates that grit is a significant mediator in the relationship between silence behavior and medication safety competence. Therefore, an integrated approach that reduces silence behavior and promotes grit is essential for strengthening nurses’ medication safety competence. Ultimately, these strategies will help ensure patient safety by improving medication safety competence.

Purpose: To identify influencing factors of media literacy, perceived neighborhood disorder, and adult attachment styles on fear of crime in adults in their 30s. Methods: Subjects were 232 adults in their 30s residing in South Korea. Data were collected through online and mobile surveys from February 21 to 26, 2024. Results: The following factors were found to significantly influence general fear of crime: female (β=.29, p<.001), perceived neighborhood disorder (β=.22, p=.002), attachment anxiety (β=.19, p=.003), and exclusion harmful media (β=.14, p=.020). These factors explained 23% of general fear of crime in adults in their 30s. The following factors significantly influenced specific fear of crime: perceived neighborhood disorder (β=.33, p<.001), attachment anxiety (β=.29, p<.001), female (β=.17, p=.003) and daily video platform usage (β=.16, p=.045). These factors explained 32% of specific fear of crime in adults in their 30s. Conclusion A multidimensional approach to understanding influencing factors of fear of crime is necessary because such an approach can serve as a basis for future public safety policies. Community mental health nurses should also increase their focus on ensuring that citizens feel safe in their communities.

This study investigated the molecular mechanism of phenotypic switching of vascular smooth muscle cells (VSMCs), which play a crucial role in vascular remodeling using 9H-Carbazol-3-yl 4-aminobenzoate (CAB). CAB significantly attenuated platelet-derived growth factor (PDGF)-induced VSMC proliferation and migration. CAB suppressed PDGF-induced STAT3 activation by directly binding to the SH2 domain of STAT3. Downregulation of STAT3 phosphorylation by CAB attenuated CIAPIN1/JAK2/STAT3 axis through a decrease in CIAPIN1 transcription. Furthermore, abrogated CIAPIN1 decreased KLF4-mediated VSMC dedifferentiation and increased CDKN1B-induced cell cycle arrest and MMP9 suppression. CAB inhibited intimal hyperplasia in injury-induced neointima animal models by inhibition of the CIAPIN1/JAK2/STAT3 axis. However, CIAPIN1 overexpression attenuated CAB-mediated suppression of VSMC proliferation, migration, phenotypic switching, and intimal hyperplasia. Our study clarified the molecular mechanism underlying STAT3 inhibition of VSMC phenotypic switching and vascular remodeling and identified novel active CAB. These findings demonstrated that STAT3 can be a major regulator to control CIAPIN1/JAK2/STAT3 axis that may be a therapeutic target for treating vascular proliferative diseases.

This review examines the pivotal clinical trials that evaluated the efficacy and safety of semaglutide, a glucagon-like peptide-1(GLP-1) receptor agonist, in the management of obesity. The reported findings underscore significant and sustained weight lossachieved with semaglutide in diverse patient groups, although gastrointestinal disorders occurred frequently, leading to therapy discontinuation. Overall, the studies demonstrated the potential of semaglutide as a therapeutic option not only for type 2 diabe-tes but also for obesity. The treatment landscape in obesity is evolving, as reflected in changing regulatory approvals and clinicalguidelines, suggesting a paradigm shift toward personalized approaches in this chronic disease states to achieve optimal treatment outcomes for patients.