OBJECTIVE To investigate the distribution of pathogens and epidemiological characteristics of the hospi-talized patients with lower respiratory tract infections(LRTI)so as to provide bases for clinical diagnosis and treatment as well as the public health prevention and control.METHODS The prevalence rates of 11 types of re-spiratory tract pathogens that were isolated from nasopharyngeal swab specimens of 3916 patients with LRTI who were hospitalized in Integrated Traditional Chinese and Western Medicine Hospital of Wenzhou Medical University from Jun.2023 to Nov.2024 were retrospectively analyzed.The age,sexes,seasons and characteristics of multi-ple infections were statistically analyzed.RESULTS The isolation rate of pathogens was 66.45％among the pa-tients with LRTI,rhinovirus(23.26％),Mycoplasma pneumoniae(17.29％)and respiratory syncytial virus(8.40％)were the main pathogens.The analysis of seasonal distribution indicated that coronavirus,influenza A/B viruses were highly prevalent in winter;Bocavirus and M.pneumoniae were active in autumn;parainfluenza vi-rus,respiratory syncytial virus and rhinovirus were prevalent in spring.There were significant differences in the i-solation rates of major species of pathogens rhinovirus,M pneumoniae and RSV among the different age groups of patients(P＜0.001).The isolation rate was highest(78.21％)among the children aged between 1 and 5 years old,and the incidence of multiple infections was highest(15.89％).The total isolation rates and incidence rates of multiple infec-tions were lower in summer than in winter,spring and autumn(P＜0.001).The detection rate of rhinovirus plus M.pneumoniae infections was highest(5.87％)among the combinations of multiple infections(5.87％),and the infec-tions were mainly prevalent in autumn.CONCLUSIONS Rhinovirus,M.pneumoniae and respiratory syncytial virus are the core pathogens isolated form the patients with LRTI in Wenzhou.The multiple infections are closely associated with the young age and season.It is suggested that the seasonal prevention and control strategies should be optimized,and the precise diagnosis and treatment assisted by the multiplex PCR technology should be promoted.

OBJECTIVE To investigate the distribution of pathogens and epidemiological characteristics of the hospi-talized patients with lower respiratory tract infections(LRTI)so as to provide bases for clinical diagnosis and treatment as well as the public health prevention and control.METHODS The prevalence rates of 11 types of re-spiratory tract pathogens that were isolated from nasopharyngeal swab specimens of 3916 patients with LRTI who were hospitalized in Integrated Traditional Chinese and Western Medicine Hospital of Wenzhou Medical University from Jun.2023 to Nov.2024 were retrospectively analyzed.The age,sexes,seasons and characteristics of multi-ple infections were statistically analyzed.RESULTS The isolation rate of pathogens was 66.45％among the pa-tients with LRTI,rhinovirus(23.26％),Mycoplasma pneumoniae(17.29％)and respiratory syncytial virus(8.40％)were the main pathogens.The analysis of seasonal distribution indicated that coronavirus,influenza A/B viruses were highly prevalent in winter;Bocavirus and M.pneumoniae were active in autumn;parainfluenza vi-rus,respiratory syncytial virus and rhinovirus were prevalent in spring.There were significant differences in the i-solation rates of major species of pathogens rhinovirus,M pneumoniae and RSV among the different age groups of patients(P＜0.001).The isolation rate was highest(78.21％)among the children aged between 1 and 5 years old,and the incidence of multiple infections was highest(15.89％).The total isolation rates and incidence rates of multiple infec-tions were lower in summer than in winter,spring and autumn(P＜0.001).The detection rate of rhinovirus plus M.pneumoniae infections was highest(5.87％)among the combinations of multiple infections(5.87％),and the infec-tions were mainly prevalent in autumn.CONCLUSIONS Rhinovirus,M.pneumoniae and respiratory syncytial virus are the core pathogens isolated form the patients with LRTI in Wenzhou.The multiple infections are closely associated with the young age and season.It is suggested that the seasonal prevention and control strategies should be optimized,and the precise diagnosis and treatment assisted by the multiplex PCR technology should be promoted.