Objective To analyze the expression levels of neuron specific enolase(NSE),stromal cell-derived factor-1(SDF-1)and decoy receptor 3(DcR3)in serum of patients with non-small cell lung cancer(NSCLC)and their prognostic value.Methods From March 2019 to March 2020,132 NSCLC patients admitted to Yixing Hospital of Traditional Chinese Medicine and the People's Hospital of Subei were collected as the study subjects(NSCLC group),another 132 healthy examinees who came to our hospital were as the control group.enzyme linked immunosorbent assay(ELISA)was applied to detect the expression levels of NSE,SDF-1,and DcR3 in serum;multivariate Logistic regression was applied to analyze the influencing factors of poor prognosis in NSCLC patients;and receiver operating characteristic(ROC)curve was applied to analyze the value of serum NSE,SDF-1,and DcR3 expression levels in evaluating the prognosis of NSCLC patients.Results The expression levels of NSE,SDF-1,and DcR3 in the serum of the NSCLC group were obviously higher than those of the control group,with statistical significance(P＜0.05);the expression levels of NSE,SDF-1,and DcR3 in the serum of NSCLC patients with a tumor diameter of≥3 cm,low tumor differentiation,TNM staging of stage Ⅲ-Ⅳ,and lymph node metastasis were obviously higher than those of NSCLC patients with a tumor diameter of＜3 cm,high/medium tumor differentiation,TNM staging of stage Ⅰ-Ⅱ,and no lymph node metastasis(P＜0.05);compared with the good prognosis group,the expression levels of NSE,SDF-1,and DcR3 in the serum of NSCLC patients in poor prognosis groupwere obviously increased,and the proportion of lymph node metastasis was obviously increased(P＜0.05);the results of multivariate Logistic regression analysis showed that NSE,SDF-1,DcR3,and lymph node metastasis were the influencing factors for poor prognosis in NSCLC patients(P＜0.05);the results of receiver operating characteristic analysis showed that the area under the curve(AUC)of serum NSE,SDF-1 and DcR3 levels in evaluating prognosis of NSCLC patients was 0.852,which was more valuable than the single index of NSE,SDF-1 and DcR3.Conclusion The expression levels of NSE,SDF-1,and DcR3 in the serum of NSCLC patients are obviously increased,and the combination of the three can be used as a prognostic indicator for NSCLC patients.

Objective To analyze the expression levels of neuron specific enolase(NSE),stromal cell-derived factor-1(SDF-1)and decoy receptor 3(DcR3)in serum of patients with non-small cell lung cancer(NSCLC)and their prognostic value.Methods From March 2019 to March 2020,132 NSCLC patients admitted to Yixing Hospital of Traditional Chinese Medicine and the People's Hospital of Subei were collected as the study subjects(NSCLC group),another 132 healthy examinees who came to our hospital were as the control group.enzyme linked immunosorbent assay(ELISA)was applied to detect the expression levels of NSE,SDF-1,and DcR3 in serum;multivariate Logistic regression was applied to analyze the influencing factors of poor prognosis in NSCLC patients;and receiver operating characteristic(ROC)curve was applied to analyze the value of serum NSE,SDF-1,and DcR3 expression levels in evaluating the prognosis of NSCLC patients.Results The expression levels of NSE,SDF-1,and DcR3 in the serum of the NSCLC group were obviously higher than those of the control group,with statistical significance(P＜0.05);the expression levels of NSE,SDF-1,and DcR3 in the serum of NSCLC patients with a tumor diameter of≥3 cm,low tumor differentiation,TNM staging of stage Ⅲ-Ⅳ,and lymph node metastasis were obviously higher than those of NSCLC patients with a tumor diameter of＜3 cm,high/medium tumor differentiation,TNM staging of stage Ⅰ-Ⅱ,and no lymph node metastasis(P＜0.05);compared with the good prognosis group,the expression levels of NSE,SDF-1,and DcR3 in the serum of NSCLC patients in poor prognosis groupwere obviously increased,and the proportion of lymph node metastasis was obviously increased(P＜0.05);the results of multivariate Logistic regression analysis showed that NSE,SDF-1,DcR3,and lymph node metastasis were the influencing factors for poor prognosis in NSCLC patients(P＜0.05);the results of receiver operating characteristic analysis showed that the area under the curve(AUC)of serum NSE,SDF-1 and DcR3 levels in evaluating prognosis of NSCLC patients was 0.852,which was more valuable than the single index of NSE,SDF-1 and DcR3.Conclusion The expression levels of NSE,SDF-1,and DcR3 in the serum of NSCLC patients are obviously increased,and the combination of the three can be used as a prognostic indicator for NSCLC patients.

Objective To investigate the value of serum interleukin-6 (IL-6) ,haptoglobin (HPT) and amy-loid A (SAA) in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) with pneumonia.Methods 87 cases of acute exacerbation of COPD without pneumonia and 76 cases with pneumo-nia ,admitted in the hospital from December 2015 to March 2017 ,were selected as COPD without pneumonia group and COPD with pneumonia group.62 healthy people who underwent the healthy assessment during the same period were selected as the control group.The changes of serum IL-6 ,HPT and SAA levels in three groups ,the value of serum IL-6 ,HPT and SAA levels in detecting COPD with pneumonia and the correlation of IL-6 ,HPT and SAA were compared.Results COPD patients with serum IL-6 ,HPT and SAA were higher than group COPD with pneumonia group and control group ,and COPD is not associated with serum IL-6 , HPT and SAA in pneumonia group than the control group (P＜0.05) ;IL-6+ HPT+SAA diagnostic specifici-ty ,sensitivity and positive predictive value is higher than IL-6 ,HPT and SAA (P＜0.05) ;IL-6 and HPT was positively related with SAA and HPT was positively correlated with SAA.The serum levels of IL-6 ,HPT and SAA in the COPD with pneumonia group were higher than those in the COPD without pneumonia group and the control group ,and the serum IL-6 ,HPT and SAA levels in the COPD without pneumonia group were higher than those in the control group ,and the difference was statistically significant (P＜0.05).The diagnos-tic specificity ,sensitivity and positive predictive value of the combined detection of IL-6 ,HPT and SAA levels were higher than those of single detection of IL-6 ,HPT and SAA level ,and the difference was statistically sig-nificant (P＜0.05) ;IL-6 level was positively correlated with HPT and SAA levels ,and HPT was positively correlated with SAA level.Conclusion The levels of serum IL-6 ,HPT and SAA in patients with acute exacer- bation of COPD increased.The combined detection of the three had relatively high sensitivity and specificity , and the levels of IL-6 ,HPT and SAA were positively correlated.