Background:: Eczema, also known as atopic dermatitis, is a chronic relapsing inflammatory skin disease characterized by defective skin barrier function. Laos is a low resource setting located in South East Asia region which very few studies related to skin health have been conducted. Objectives: : This study aimed to clinical Screening and Treatment of Eczema: A Prospective Study among Children under 5 Years Old Presenting to Children’s Hospital, Setthathilath Hospital and Mahosot Hospital, Lao PDR Methodology: : This study was a descriptive cross-sectional design study, conducted from May to November 2023. In all, 478 children attended OPD with a skin complaint. Children visited the Outpatient department in Children’s Hospital, Setthathilath Hospital, Mahosot Hospital, of whom 208 children diagnosed with eczema were included in study. Results: : Among 208 children, 130 (62.5%) had flexor involvement and 78 (37.5%) had extensor involvement. The main drugs used for treatment were emollient cream and topical corticosteroids in 157 (75.48%) From a clinical point of view, these findings are often a source of parental anxiety and medical concern for in experienced clinicians. Conclusion: Eczema (atopic dermatitis) in Lao children is often a source of parental anxiety and presents management challenges for in experienced clinicians, correct diagnosis and parental counselling may relieve anxiety. General paediatricians should be able to reassure parents of children with eczema and manage skin lesions using emollients and topical corticosteroids.