Objective:To investigate the predictive value of uterine artery hemodynamic parameter monitoring in the first trimester on pregnancy outcomes in patients with recurrent pregnancy loss (RPL).Methods:The RPL patients were selected from the Department of Reproductive and Immunology of Shanghai First Maternal and Infant Hospital between November 2012 and May 2018. RPL patients were divided into live birth group and miscarriage group according to their pregnancy outcome. Case-control studies were designed to compare the two groups in hemodynamic parameters of transvaginal ultrasonography-uterine artery during first trimester.Results:Totally 348 cases in the live birth group and 312 cases in the miscarriage group were enrolled. As the gestational week increases, peak uterine artery systolic/end-diastolic velocity (S/D), pulsatility index (PI), and blood flow resistance index (RI) increased in both groups; compared with miscarriage group, uterine artery S/D, PI, and RI of live birth group decreased by 3.462 1 (95% CI=-6.483 5-0.440 8, P=0.025 2), 0.474 2 (95% CI=-1.000 5-0.052 1, P=0.078 1), and 0.054 6 (95% CI=-0.111 5-0.002 4, P=0.060 9), respectively. Uterine artery S/D, PI, RI slope rates in live birth group were 0.064 5 (95% CI=0.013 6-0.115 9, P=0.014 5), 0.009 4 (95% CI=0.000 5-0.018 4, P=0.039 4), and 0.001 1 (95% CI=0.000 1-0.002 0, P=0.032 2) higher than those in miscarriage group during early pregnancy. Conclusion:The slope rate of uterine arterial blood flow parameters in live birth group is faster than that in miscarriage group. Monitoring of uterine arterial blood flow during the first trimester may have a predictive value for pregnancy outcomes in RPL patients.

Objective:To investigate the predictive value of uterine artery hemodynamic parameter monitoring in the first trimester on pregnancy outcomes in patients with recurrent pregnancy loss (RPL).Methods:The RPL patients were selected from the Department of Reproductive and Immunology of Shanghai First Maternal and Infant Hospital between November 2012 and May 2018. RPL patients were divided into live birth group and miscarriage group according to their pregnancy outcome. Case-control studies were designed to compare the two groups in hemodynamic parameters of transvaginal ultrasonography-uterine artery during first trimester.Results:Totally 348 cases in the live birth group and 312 cases in the miscarriage group were enrolled. As the gestational week increases, peak uterine artery systolic/end-diastolic velocity (S/D), pulsatility index (PI), and blood flow resistance index (RI) increased in both groups; compared with miscarriage group, uterine artery S/D, PI, and RI of live birth group decreased by 3.462 1 (95% CI=-6.483 5-0.440 8, P=0.025 2), 0.474 2 (95% CI=-1.000 5-0.052 1, P=0.078 1), and 0.054 6 (95% CI=-0.111 5-0.002 4, P=0.060 9), respectively. Uterine artery S/D, PI, RI slope rates in live birth group were 0.064 5 (95% CI=0.013 6-0.115 9, P=0.014 5), 0.009 4 (95% CI=0.000 5-0.018 4, P=0.039 4), and 0.001 1 (95% CI=0.000 1-0.002 0, P=0.032 2) higher than those in miscarriage group during early pregnancy. Conclusion:The slope rate of uterine arterial blood flow parameters in live birth group is faster than that in miscarriage group. Monitoring of uterine arterial blood flow during the first trimester may have a predictive value for pregnancy outcomes in RPL patients.