Background: This research’s aims are to determine the prevalence of anxiety among students at Hanoi Medical University in the academic year 2020-2021 and some related factors. Methods: This study used a descriptive cross-sectional study on 1325 students at Hanoi Medical University, using DASS-21 scale with questionnaire of anxiety subscale and a self-designed questionnaire. Students were chosen to the study conveniently during the period of data collection. Results: The result of this study showed that the prevalence of anxiety among students was 42.3%. In this population, the moderate subgroup accounted for the biggest prevalence, at 19.1%. The figures for other subgroups, including mild, severe and extremely severe, were 8%, 6.6% and 8.6% respectively. Relevant factors to students’ anxiety were financial difficulties, online learning difficulties and a factor related to Covid 19, which was “afraid of coming home due to the chance of infecting family members with the disease”. Conclusion: Nearly half of students were likely to have anxiety disorders, requiring support measures. Students needed to practice physical exercises, manage schedules to improve their health. Besides, universities should provide financial and academic support to struggling students.