Objective:To explore the heterogeneity of alienation among adolescents and examine the impact of child psychological maltreatment, childhood bullying, online social exclusion, and demographic variables.Methods:In October 2023, the alienation scale was administered to 1 316 adolescents. Latent profile analysis was conducted using Mplus 8.3, and multinomial Logistic regression analysis was performed using SPSS 26.0 to explore the factors associated with the heterogeneity of adolescent alienation.Results:(1) The score of adolescent alienation was 22.00 (17.00, 29.00). The results of latent profile analysis showed that there was heterogeneity in adolescent alienation, which could be divided into two categories as low alienation (66.79%, 879/1 316) and high alienation (33.21%, 437/1 316).(2) Binary Logistic regression analysis showed that gender ( B=0.57, OR=1.77, P<0.01), being an only child ( B=-0.34, OR=0.71, P<0.05) were significantly associated with adolescent alienation. Additionally, child psychological maltreatment( B=1.61, OR=5.02, P<0.01), childhood bullying ( B=1.09, OR=2.98, P<0.01), and online social exclusion ( B=1.64, OR=5.17, P<0.01) were identified as critical factors influencing adolescent alienation. Conclusion:There is heterogeneity in alienation among adolescents. Child psychological maltreatment, child bullying, online social exclusion and demographic variables are the main influencing factors of alienation among adolescents.

Objective:To evaluate the reliability and validity of the Chinese version of the Oxford agoraphobic avoidance scale (OAAS-C) in Chinese college students.Methods:A total of 1 030 college students were surveyed with OAAS-C, general anxiety disorder-7(GAD-7), the center for epidemiological studies depression scale-10 (CESD-10) and the symptom checklist-90(SCL-90). Sample 1( n=30) was carried out for popularity test. Sample 2( n=503) was carried out for item analysis and exploratory factor analysis. Sample 3( n=497) was carried out for confirmatory factor analysis. Two weeks later, 60 college students who came from sample 2 were asked to retest OAAS-C. SPSS 26.0 and Mplus 8.3 were used for data analysis. Results:According to exploratory factor analysis, the OAAS-C was a single dimension scale included with 8 items, and explained 60.75% of the total variance.The confirmatory factor analysis showed that the single factor model fitted the data well( χ2/ df=1.41, CFI=0.99, TLI=0.98, RMSEA=0.05). The score of OAAS-C was positively correlated with the scores of GAD-7, CESD-10 and the agoraphobic subscale of SCL-90 ( r=0.72, 0.71, 0.87, all P<0.01). In addition, the composite reliability coefficient was 0.91 and average variance extracted coefficient was 0.55.The Cronbach's α coefficient of the OAAS-C was 0.93, the retest reliability coefficients(ICC) was 0.86, and the split-half reliability coefficient was 0.90. Conclusion:OAAS-C has a good reliability and validity in Chinese college students and it can be used as a research tool for agoraphobic study.

Objective:To explore the heterogeneity of alienation among adolescents and examine the impact of child psychological maltreatment, childhood bullying, online social exclusion, and demographic variables.Methods:In October 2023, the alienation scale was administered to 1 316 adolescents. Latent profile analysis was conducted using Mplus 8.3, and multinomial Logistic regression analysis was performed using SPSS 26.0 to explore the factors associated with the heterogeneity of adolescent alienation.Results:(1) The score of adolescent alienation was 22.00 (17.00, 29.00). The results of latent profile analysis showed that there was heterogeneity in adolescent alienation, which could be divided into two categories as low alienation (66.79%, 879/1 316) and high alienation (33.21%, 437/1 316).(2) Binary Logistic regression analysis showed that gender ( B=0.57, OR=1.77, P<0.01), being an only child ( B=-0.34, OR=0.71, P<0.05) were significantly associated with adolescent alienation. Additionally, child psychological maltreatment( B=1.61, OR=5.02, P<0.01), childhood bullying ( B=1.09, OR=2.98, P<0.01), and online social exclusion ( B=1.64, OR=5.17, P<0.01) were identified as critical factors influencing adolescent alienation. Conclusion:There is heterogeneity in alienation among adolescents. Child psychological maltreatment, child bullying, online social exclusion and demographic variables are the main influencing factors of alienation among adolescents.

Objective:To evaluate the reliability and validity of the Chinese version of the Oxford agoraphobic avoidance scale (OAAS-C) in Chinese college students.Methods:A total of 1 030 college students were surveyed with OAAS-C, general anxiety disorder-7(GAD-7), the center for epidemiological studies depression scale-10 (CESD-10) and the symptom checklist-90(SCL-90). Sample 1( n=30) was carried out for popularity test. Sample 2( n=503) was carried out for item analysis and exploratory factor analysis. Sample 3( n=497) was carried out for confirmatory factor analysis. Two weeks later, 60 college students who came from sample 2 were asked to retest OAAS-C. SPSS 26.0 and Mplus 8.3 were used for data analysis. Results:According to exploratory factor analysis, the OAAS-C was a single dimension scale included with 8 items, and explained 60.75% of the total variance.The confirmatory factor analysis showed that the single factor model fitted the data well( χ2/ df=1.41, CFI=0.99, TLI=0.98, RMSEA=0.05). The score of OAAS-C was positively correlated with the scores of GAD-7, CESD-10 and the agoraphobic subscale of SCL-90 ( r=0.72, 0.71, 0.87, all P<0.01). In addition, the composite reliability coefficient was 0.91 and average variance extracted coefficient was 0.55.The Cronbach's α coefficient of the OAAS-C was 0.93, the retest reliability coefficients(ICC) was 0.86, and the split-half reliability coefficient was 0.90. Conclusion:OAAS-C has a good reliability and validity in Chinese college students and it can be used as a research tool for agoraphobic study.

Objective:Revise the Chinese version of body dysmorphic disorder scale (CBDDS) and test its reliability and validity in Chinese college students.Methods:In October 2022, college students were surveyed with the body dysmorphic disorder scale (BDDS), the body image disorders scale (BIDS), the appearance anxiety scale-brief (AAS-B), the Chinese body shame scale (CBSS) and short-depression scale (SDS). Totally 59 college students (sample 1) were subjected to evaluate the popularity degree of the scale, 493 college students (sample 2) were subjected to complete item and exploratory factor analysis, 457 colleges students (sample 3) were subjected to complete the confirmatory factor analysis, totally 89 colleges students (sample 4) were subjected to complete the re-test reliability analysis.SPSS 25.0 software was used for item analysis, exploratory factor analysis, reliability analysis, Pearson correlation analysis.AMOS 24.0 software was used for confirmatory factor analysis, convergent validity analysis.Results:(1) The CBDDS was consisted of 3 dimensions including pathological beliefs, appearance anxiety and overgrooming, and the three-factor model fitted well ( χ2/ df=3.14, GFI=0.93, CFI=0.91, TLI=0.91, RMSEA=0.07). (2) The score of CBDDS was positively correlated with the score of BIDS, AAS-B, CBSS and SDS ( r=0.41-0.81, all P<0.01). In addition, the composite reliability coefficients were 0.75-0.95 and AVE coefficients were 0.51-0.56.(3) The CBDDS had good internal reliability with Cronbach's α coefficients from 0.75 to 0.94, split-half reliability coefficients from 0.65 to 0.90 and re-test reliability coefficients from 0.71 to 0.91 (all P<0.01). Conclusion:The CBDDS has acceptable reliability and validity and can be an effective scale for Chinese college students.

Objective:To evaluate the efficacy and safety of hypomethylating agents (HMA) in patients with myelodysplastic syndromes (MDS) .Methods:A total of 409 MDS patients from 45 hospitals in Zhejiang province who received at least four consecutive cycles of HMA monotherapy as initial therapy were enrolled to evaluate the efficacy and safety of HMA. Mann-Whitney U or Chi-square tests were used to compare the differences in the clinical data. Logistic regression and Cox regression were used to analyze the factors affecting efficacy and survival. Kaplan-Meier was used for survival analysis. Results:Patients received HMA treatment for a median of 6 cycles (range, 4-25 cycles) . The complete remission (CR) rate was 33.98% and the overall response rate (ORR) was 77.02%. Multivariate analysis revealed that complex karyotype ( P=0.02, OR=0.39, 95% CI 0.18-0.84) was an independent favorable factor for CR rate. TP53 mutation ( P=0.02, OR=0.22, 95% CI 0.06-0.77) was a predictive factor for a higher ORR. The median OS for the HMA-treated patients was 25.67 (95% CI 21.14-30.19) months. HMA response ( P=0.036, HR=0.47, 95% CI 0.23-0.95) was an independent favorable prognostic factor, whereas complex karyotype ( P=0.024, HR=2.14, 95% CI 1.10-4.15) , leukemia transformation ( P<0.001, HR=2.839, 95% CI 1.64-4.92) , and TP53 mutation ( P=0.012, HR=2.19, 95% CI 1.19-4.07) were independent adverse prognostic factors. There was no significant difference in efficacy and survival between the reduced and standard doses of HMA. The CR rate and ORR of MDS patients treated with decitabine and azacitidine were not significantly different. The median OS of patients treated with decitabine was longer compared with that of patients treated with azacitidine (29.53 months vs 20.17 months, P=0.007) . The incidence of bone marrow suppression and pneumonia in the decitabine group was higher compared with that in the azacitidine group. Conclusion:Continuous and regular use of appropriate doses of hypomethylating agents may benefit MDS patients to the greatest extent if it is tolerated.

Objective:To revise the Social Fat Perception Scale(SI-FAT)and test its validity and reliability in female college students.Methods:A total of 564 female college students(sample 1)were recruited for explora-tory factor analysis.In addition,557 female college students(sample 2)were recruited to conduct confirmatory fac-tor analysis,validity of correlation and convergence validity of targets,and internal consistency reliability testing.Fifty-nine female college students(sample 3)were recruited for retesting 1 week apart The Social Physical Anxiety Scale(SPA)and Brief Fear of Negative Evaluation Scale(BFNES)were used as benchmarking tools.Results:The Chinese version of SI-FAT had a 4-factor(parent,peer,partner,media)structure,a total of 16 i-tems,the cumulative amount of explanatory variance was 76.64％,and the item load was between 0.65-0.94,and the confirmatory factor analysis showed that the model fit was good(x2/df=4.48,CFI=0.94,TLI=0.92,SRMR=0.06,RMSEA=0.08).The SI-FAT scores were positively correlated with the scores of SPA and BFNES(ICC=0.40,0.43,P＜0.001).The Cronbach α coefficients of the SI-FAT scale and its 4 factors were 0.83-0.94,and the retest reliabilities(ICC)were 0.61-0.68.Conclusion:The Chinese version of the Social Fat Perception Scale has a good validity and reliability in assessing the perception of social fat in female college students.

Objective:To develop the College Students'Perceived Social Mindfulness Scale(C-PSMS)and test its validity and reliability.Methods:Based on the results of literature analysis,the psychological structure of perceived social mindfulness was formulated,25 college students were selected for semi-structured interview,and the initial scale was determined after item evaluation.809 college students were recruited to finish the initial scale for items analysis and exploratory factor analysis to form the formal administration scale.689 college students were selected for confirmatory factor analysis,criterion related validity and internal consistency reliability test,with the Positive Affect and Negative Affect Scale(PANAS)and Interpersonal Trust Scale(ITS)as validity criterion,which formed the formal scale.Totally 80 college students were assessed with C-PSMS after one month later.Results:There were 18 items in the C-PSMS,with a single dimension,the factor loadings ranged 0.61 to 0.75,the structural validity was good(x2/df=3.55,NFI=0.93,IFI=0.95,TLI=0.94,CFI=0.95,RMSEA=0.06).The C-PMS scores were positively correlated with the PANAS positive affect scores and ITS scores(r=0.62、0.52,PS＜0.01),and negatively correlated with the PANAS negative affect scores(r=-0.42,P＜0.01).The Cronbach α coefficient was 0.94,and the test-retest reliability was 0.74.Conclusion:The College Students'Perceived Social Mindfulness Scale(C-PSMS)in this study meets the psychometric standards.

Objective: To explore the longitudinal relationship between upward social comparison and online aggressive behavior among college students, in order to provide an empirical evidence for educators to carry out mental health promotion for college students. Methods: From December 2021 to March 2022, 539 college students from one university in Inner Mongolia were recruited to complete the Upward Social Comparison Questionnaire (USCQ) and Online Aggressive Behavior Scale (OABS) in a 4 month follow-up study. The structural equation model was used to conduct cross-lagged analysis. Results: The mean scores of upward social comparison for college students tracked at baseline (T1) and 4 months follow-up (T2) were (2.77±0.93, 2.70±1.00) points, and the mean scores of online aggressive behavior were (1.06±0.13, 1.05±0.11) points. There were positive relations between upward social comparison and online aggressive behavior of college students at both cross-sectional levels ( r=0.14-0.19, P <0.05). In the autoregression, T1 upward social comparison could positively predict T2 upward social comparison ( β =0.66), and T1 online aggressive behavior could positively predict T2 online aggressive behavior ( β =0.47)( P <0.01); In the cross-lagged regression, T1 upward social comparison could positively predict T2 online aggressive behavior ( β=0.10, P <0.01), whereas T1 online aggressive behavior could not predict T2 upward social comparison ( β=0.04, P >0.05). Conclusion Upward social comparison is the cause of online aggressive behavior among college students. The probability of online aggressive behavior among college students should be reduced by guiding students to correctly view the gap between themselves and others.

Objective:To investigate the relationship between childhood abuse experience and suicide attitude among male prisoners, and the mediating effect of impact of event and thought suppression.Methods:Totally 370 male prisoners were tested by personal report of childhood abuse(PRCA), impact of event scale(IES), white bear suppression inventory(WBSI) and suicide attitude inventory(SAI). SPSS 22.0 was used for correlation analysis, regression analysis and other statistical analysis.Results:The scores of PRCA, IES, WBSI and SAI were (2.60±0.62), (2.69±0.62), (2.83±0.79), (3.06±0.61), respectively.There were significant differences in the scores of PRCA, IES and WBSI among different suicide attitude groups( F=42.69, 51.06, 78.76, all P<0.01). After controlling age variables, positive correlation was observed between PRCA, IES, WBSI and SAI ( r=0.38-0.76, all P<0.01). Impact of event and thought suppression played a mediating role in the relationship between childhood abuse experience and suicide attitude among male prisoners.The mediating effect included three paths: one was the single mediating effect of impact of event, the other was the single mediating effect of thought suppression and the third was the chain mediating effect of impact of event and thought suppression, and the effect values were 0.29, 0.23 and 0.05, respectively. Conclusion:Childhood abuse experience not only directly influences male prisoners' suicide attitude, but also indirectly influences their suicide attitude through the mediating effects of impact of event and thought suppression.