1.Clinical ophthalmic evaluation of post-traumatic carotid-cavernous fistula
Viona VIONA ; Mansyur YUNITA ; Todja Umar BATARI ; Bahar ASHARI
International Eye Science 2026;26(9):1506-1516
AIM: To identify clinical and fundoscopic predictors of visual outcomes in post-traumatic carotid-cavernous fistula(CCF)and report the relationship between diagnostic delay, angiographic closure rates, and functional prognosis.METHODS: This retrospective case series reports patients with post-traumatic CCF confirmed by digital subtraction angiography between January 2024 and October 2025. Comprehensive ophthalmic evaluation included visual acuity, intraocular pressure(IOP), fundoscopy, relative afferent pupillary defect(RAPD), and color vision. Clinical presentation patterns, fundoscopic findings, and visual outcomes were systematically documented and analyzed descriptively.RESULTS: Eight patients(5 males, 3 females, mean age 28.5±13.2 y)were included; 7 cases(88%)from motor vehicle accidents. Mean diagnostic delay was 2.6±1.6 mo; 7 cases(88%)presented beyond 6 wk. Secondary glaucoma developed in 5 cases(63%). Bilateral signs and symptoms occurred in 3 cases(38%)despite unilateral fistulas. Type A direct CCF predominated(7 cases, 88%). Fundoscopic examination revealed three presentations: normal disc(2 cases, 25%), optic disc edema(3 cases, 38%), and optic atrophy(3 cases, 38%). Despite complete angiographic closure in only 3 cases(38%), visual outcomes seemed more closely associated with baseline fundoscopic findings than closure rates. Patients with optic atrophy(n=3)demonstrated poor visual prognosis(final visual acuity ranging no light perception to 20/30), while those with normal fundus(n=2)achieved excellent recovery(final visual acuity 20/20-20/25). Patients with disc edema(n=3)showed variable outcomes depending on disease severity, ranging from complete recovery to persistent visual loss. One patient experienced contralateral visual decline(20/20 to 20/150)following partial embolization.CONCLUSION: With 88% of patients presenting beyond the critical six-week therapeutic window, early recognition of post-traumatic CCF remains a major challenge in resource-limited settings. Visual outcomes corresponded with baseline fundoscopic findings rather than angiographic closure rates. Patients with established optic atrophy(38%)demonstrated minimal visual recovery regardless of treatment success, while those with preserved disc architecture achieved favorable outcomes. In settings where advanced imaging is unavailable, systematic neuro-ophthalmic examination—particularly RAPD testing and fundoscopy—enables both early diagnosis and prognostic assessment.
2.Review of the Benefits of Eggshell Content in Body Tissue Structure Repair
Hastuti Herman ; Rahmawati Minhajat ; Mirna Muis ; Batari Todja Umar ; Muhammad Husni Cangara ; Andi Alfian Zainuddin
Malaysian Journal of Medicine and Health Sciences 2023;19(No.2):278-285
Eggshell (ES) is a waste material that cannot be consumed with low economic value. ES mainly contains calcium
carbonate (CaCO3) and an organic matrix in the form of proteins, glycoproteins, and proteoglycans. Meanwhile,
the eggshell membrane (ESM) contains osteopontin collagen, fibronectin, keratin, histones, avian beta defensins,
ovocalyxin-36, apolipoproteins, protocadherin, chondroitin sulfate, ovotransferrin, hyaluronic acid, and sialic acid
as well as various amino acids. Recently, ES has been widely used in industry, agriculture, food, and medical fields.
The potential of ES in the medical field is interesting to discuss, especially in relation to tissue repair. Efforts to reduce
the prevalence of wounds that generally originate from acute wounds but become chronic due to various factors
that are neglected in their management. In particular, this review will describe the benefits of ES content in repairing
body tissues. ES-derived active ingredients such as CaCO3, brushite, and hydroxyapatite exhibit osteoconductive
properties that promote bone regeneration. Calcium ions can increase insulin and leptin sensitivity in the liver and
can induce repair of acute kidney injury. Meanwhile, ESM contributes positively to neural tissue repair and plays an
important role in wound healing, response to external stimuli, defense response, inflammatory response, cell-substrate adhesion, promoting cell growth, migration, differentiation, and tissue remodeling.


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