Background With the unprecedented development of aviation business, the work load and job burnout of airport employees are becoming more and more serious, and the impact on sleep quality needs to be addressed. Objective To explore the current situation of work load and sleep quality of airport employees, and whether job burnout plays a role in the relationship between the two variables. Methods During September 2023, a cross-sectional survey was conducted among employees of an airport in Hunan Province, and 1503 employees were surveyed. A basic information questionnaire, a work load measurement questionnaire, Maslach Burnout Inventory General Survey, and Pittsburgh Sleep Quality Index were used in the survey. Logistic regression was used to analyze the influencing factors of sleep quality. SPSS 25.0 PROCESS v4.1 plug-in was used to analyze the mediating effect of job burnout. Results A total of 1503 questionnaires were distributed in this study, and 1424 valid questionnaires were recovered, with a recovery rate of 94.7%. The rate of heavy work load was 50.0% (712/1424), the rate of job burnout was 74.6% (1062/1424), and the rate of sleep disorders was 58.7% (836/1424). The results of logistic regression analysis showed that individuals with job burnout had a 1.734 times higher risk of reporting sleep disorders compared to those without job burnout (95% CI: 1.306, 2.302); compared to those with light work load, individuals with heavy work load have a higher risk of sleep disorders (OR=3.422, 95%CI: 2.639, 4.437). The results of mediating effect test indicated a work load-burnout-sleep quality pathway (P <0.001), with a mediation effect value of 0.1052 (95%CI: 0.019, 0.067), accounting for 18.02% of the total effect. Conclusion The rate of job burnout and the rate of reporting poor sleep quality are high among airport employees, and job burnout plays a mediating role in the relationship between work load and sleep quality. Adopting measures to reduce work load and reduce burnout can improve the sleep quality of airport employees.

Objective To analyze the expression of eIF 4A in cervical cancer and different levels of cervical neoplasia tissues and its clinical significance.Methods 80 cases of cervical cancer were included in the diagnosis of cervical cancer,40 patients with high cervical intraepithelial neoplasia (CIN grade Ⅱ and grade Ⅲ) and 40 cases of low grade cervical intraepithelial neoplasia (CIN Ⅰ) were incorporated into the experimental group between February 2012 and March 2015 in hospital,and patients with total hysterectomy,pathological diagnosis of normal cervix were included in the control group.Expression level of eIF-4A protein in cervical cancer tissues,different levels of cervical neoplasia tissues and normal tissue was determined by immunohistochemical method,to investigate the relationship between the pathology and clinical grading and staging of cervical cancer.Results The expression of eIF-4A proteins in the different tissues were normal cervical tissue (0.0％),CIN Ⅰ (52.5％),CIN Ⅱ and Ⅲ (77.5％),cervical cancer(81.8％).The positive expression rate was gradually increasing trend,the difference was statistically significant (x2 =77.874,P ＜ 0.05),the linear trend test was statistically significant (x2 =65.810,P ＜ 0.05).The expression of eIF-4A proteins in CIN Ⅱ and Ⅲ have no significant difference (x2 =0.292,P ＞ 0.05).The expression of eIF-4A proteins in cervical cancer were independent of the type of organization (x2 =0.779,P =0.377);related to its histological grad(x2 =8.042,P =0.018);and related to its clinical staging(x2 =6.765,P =0.009).Conclusion The expression of eIF-4A proteins may be associated with the occurrence and development of cervical cancer,it may be plays a role in the cervical cancer initiation process.