Objective To investigate the epidemiological characteristics of respiratory syncytial virus (RSV) infection in elderly patients at a hospital in Hengshui and its correlation with climatic and environmental factors. Methods A retrospective study was conducted on 826 elderly patients with RSV infection who were hospitalized in the Department of Respiratory and Critical Care Medicine Department of Hengshui People's Hospital from June 2022 to May 2024. Clinical data of the patients were collected. Based on the climatic and environmental data of the Hengshui region during the same period, the epidemiological characteristics of RSV in the elderly population were analyzed. Pearson analysis was used to examine the correlation between RSV incidence and climatic and environmental factors. Results Among the 826 elderly RSV infected patients, males (54.24%) had a higher incidence than females (45.76%). The age of onset was highest in elderly people aged ≥ 80 (39.47%), followed by the age group of 70-79 (32.08%). Cough (89.95%) and sputum (71.19%) were the main clinical symptoms of elderly RSV infected patients. 28.57% of the elderly patients with RSV infection had basic diseases, of which the patients with diabetes accounted for the highest proportion (12.35%), followed by cardiovascular diseases (10.41%). The proportion of patients with mixed infections reached 4.60%, and the proportion of patients with other systemic complications reached 1.69%. From the perspective of the season of onset, the number of elderly RSV cases was highest in spring and winter, accounting for 39.47% and 47.09%, respectively. The correlation analysis results showed that the number of elderly RSV cases was negatively correlated with average wind speed (r=-0.196), average temperature (r=-0.731), and average humidity (r=-0.729), and weakly positively correlated with average atmospheric pressure (r=0.085) (all P<0.05). Conclusion In the elderly population, RSV infection is more prevalent among males and the very old, with a higher incidence during the winter and spring seasons, and is closely related to climate changes in the Hengshui region.

In 2018,a consensus on the new international classification of periodontal diseases and peri-implant diseases was jointly published by the American Academy of Periodontology(AAP)and European Federation of Periodontology(EFP),which divided peri-odontitis into stages Ⅰ-Ⅳ.The diagnosis and treatment of stage Ⅲ/Ⅳ periodontitis are the focus and difficulty in clinical practice.De-veloping standardized clinical decision-making for the diagnosis and treatment of stage Ⅲ/Ⅳ periodontitis can help patients with this condition achieve better plaque control,maintain healthy periodontal status and restore chewing function and aesthetics.Based on the EFP S3 level clinical guidelines for the treatment of stage Ⅰ-Ⅲ and stage Ⅳ periodontitis,combined with the new international classi-fication of periodontal diseases and peri-implant diseases in 2018 and the Chinese expert consensus on the diagnosis of severe periodon-titis in 2017,this article elaborates clinical diagnosis and treatment decisions for stage Ⅲ/Ⅳ periodontitis,aiming to provide reference for clinical application practice.

Objective:To evaluate clinical efficacy of local treatment for prostate cancer patients with bone metastases at the initial diagnosis.Methods:Clinical data of 211 prostate cancer patients with bone metastases at the initial diagnosis admitted to the First Affiliated Hospital of Soochow University from January 2014 to December 2021 were retrospectively analyzed. All patients were divided into the systemic and combined local treatment groups according to whether they received local treatment or not. Patients in the combined local treatment group were further divided into the prostatectomy and radical radiotherapy groups. According to whether they received radiotherapy, they were divided into the radiotherapy and non-radiotherapy groups. Statistical analysis was performed by SPSS 26.0 statistical software. The differences in the survival of patients among different groups were analyzed and compared by Kaplan-Meier method and log-rank test. The comparison was repeatedly conducted after the propensity score matching. Clinical characteristics and treatment factors of patients were included in Cox's proportional hazard regression model, and their relationship with survival was analyzed.Results:Compared with systemic treatment, local treatment significantly improved the 5-year clinical progression-free survival (CPFS) and 5-year overall survival (OS) ( P=0.049, 0.010). After propensity score matching was performed, patients in the local treatment group outperformed those in the systemic treatment in 5-year biochemical progression-free survival (BPFS) and 5-year OS ( P=0.036, 0.029). There were no statistically significant differences in 5-year BPFS, CPFS and OS between the prostatectomy and radical radiotherapy groups. Radiotherapy improved 5-year BPFS and 5-year OS compared with non-radiotherapy ( P=0.030, 0.020). After propensity score matching was performed, 5-year BPFS and 5-year OS in the radiotherapy group remained significantly higher than those in the non-radiotherapy group ( P=0.046, 0.047). Overall, patients who received radiotherapy were well tolerated and did not experience serious radiation-related adverse events. Radiotherapy improved 5-year OS for patients who were older than 65 years, had bone metastases confined to the pelvis and had a Gleason score of ≤ 8 ( P=0.039, 0.024, 0.036). Conclusions:Local treatment, especially radiotherapy, prolongs BPFS and OS rates in prostate cancer patients with bone metastases at first diagnosis. Radiotherapy appears to be more effective in patients of advanced age, with bone metastases confined to the pelvis and with relatively low Gleason scores.

Metastatic colorectal cancer (mCRC) is a clinical and molecular heterogeneous disease. Currently, for mCRC, extended rat sarcoma (RAS) testing is recommended in routine clinical practice before any treatment. RAS mutational status is significantly associated with the outcome of patients and strongly predictive for anti-EGFR-targeted therapy. However, specific treatments for RAS target are not yet available. Previous studies have shown that direct inhibition of RAS proteins has limited clinical benefits. Recently, a promising drug, AMG-510, which can directly inhibit KRAS G12C has been reported; however, it needs further confirmation. In the past few years, important advances have also been made in approaches designed to indirectly target RAS by inhibiting RAS effectors, multi-target combination strategies and immunotherapy. They are expected to be effective treatments for RAS target. This article summarizes the precision treatment of RAS-mutant mCRC.

The relatively high abundance of geochemical elements such as Nb, Zr, Y and other elements shows serious interferences in the determination of trace silver in geochemical samples by inductively coupled plasma-mass spectrometry ( ICP-MS) . Thus it will lead to large deviation in the determination of geochemical samples without separation and enrichment. The traditional emission spectrum or graphite furnace atomic absorption method is only single-element analysis to the silver and with bad sample representativeness. In this study, load diphenylthiourea ( DPTU) foam selective enrichment was used for the separation of Au and Ag from other interfering elements in geological samples, and thiourea liberation-ICP-MS method was developed for the simultaneous determination of Au and Ag. The samples were first decomposed by 1:1 aqua regia. After addition of 50 mL of water, the samples were adsorbed under oscillation for 30 min at 20℃. The detection limits of the Au and Ag were 0. 02 ng/g and 0. 007μg/g, respectively. The proposed method was successfully applied to the determination of Au and Ag in eight national standard materials.

Objective To study the changes of negative symptoms in PCP-induced schizophrenia rat model.Methods Thirty newborn female SD rats randomly divided into control group,PCP-week 6 group and PCP-week 10 group( n=10 in each group).Perinatal rat treated with PCP ( 10 mg/kg) on postnatal days 7,9 and 11(10 mg/kg,ip),and sucorse intalce test(SIT),forced swimming test(FST) and resident-intruder test(RIT) were used to test the emotional and negative symptoms.Results In the SIT,there was no difference between control and PCP groups (con:(28.24 ±0.86) ml/kg; week 6:(26.57 ± 1.01 ) ml/kg; week 10:(27.98 ±0.99) ml/kg,F =12.35,P ＞ 0.05 ).In the FST,PCP model rats showed longer still time ( con:(39.32 ± 1.98 ) s ; week 6:(52.39 ± 1.66)s,week 10:(55.56 ± 1.49)s,F=3.99,P＜ 0.05 ).In the RIT,PCP models rats showed less explore time ( (40.31 ± 13.56)s vs (63.90 ± 13.12)s,(43.65 ±12.86 )s vs (65.18 ± 15.12)s,P ＜ 0.05 ) and more escape time ((19.33±2.26) s vs (9.26 ± 1.32) s,(17.79 ±2.99) s vs (9.38 ± 1.36) s,P＜ 0.05).Conclusion Perinatal PCP injection can induce the long-lasting negative-symptoms changes.