Objective:To explore the correlation between abdominal aortic calcification (AAC) and bone mineral density (BMD) in postmenopausal women.Methods:This retrospective analysis was conducted on postmenopausal women hospitalized at the Geriatric Medicine Center of Beijing Jishuitan Hospital affiliated with Capital Medical University from April 2020 to October 2023.All subjects underwent dual-energy X-ray bone density testing and lateral lumbar X-ray examination and met the inclusion and exclusion criteria.The Kauppila calcification scoring method was used to assess the abdominal aortic calcification score (AACS). Patients were divided into two groups based on the AACS results: patients without or with mild AAC (AACS ≤ 4) and patients with moderate or severe AAC (AACS > 4). The correlation between AACS and BMD/T-scores at various sites was analyzed.Subgroup analyses were conducted based on the presence of hypertension, hyperlipidemia, renal dysfunction, and the number of comorbidities to evaluate the differences in their correlation in different groups.Results:A total of 188 postmenopausal women was enrolled in this study, with a mean age of (70.79 ± 8.82) years.Among them, 145 patients were classified in the group without or with mild AAC, and 43 patients with moderate or severe AAC.Compared with the group without or with mild AAC, the patients in the group with moderate to severe AAC had significantly lower BMD and T-scores in the femoral neck and total hip (all P<0.05). The Spearman correlation analysis revealed significantly negative correlations between AACS and T- scores in the femoral neck and total hip ( P<0.025), with even stronger correlations observed in patients with hypertension or renal dysfunction; besides, the correlation between AACS and hip BMD T-scores was even more significant in patients with hyperlipidemia, as well as those with two or more comorbidities.Multivariate logistic regression analysis indicated that AACS was an independent risk factor for decreased T-scores in the femoral neck (T<-2.5) ( OR=1.127, 95% CI: 1.030-1.234, P=0.009) and total hip (T<-2.5) ( OR=1.119, 95% CI: 1.023-1.224, P=0.014) in postmenopausal women. Conclusions:AAC is highly prevalent among postmenopausal women.Those with moderate to severe AAC tend to have lower hip BMD.AACS is significantly negatively correlated with T-scores of the femoral neck and total hip, and this result is more pronounced in patients with hypertension, hyperlipidemia, and renal dysfunction.Its correlation with the hip T-score is even more significant in patients with hyperlipidemia, as well as those with two or more comorbidities.AACS is an independent risk factor for the decline of hip BMD in postmenopausal women.

Objective:To explore the correlation between abdominal aortic calcification (AAC) and bone mineral density (BMD) in postmenopausal women.Methods:This retrospective analysis was conducted on postmenopausal women hospitalized at the Geriatric Medicine Center of Beijing Jishuitan Hospital affiliated with Capital Medical University from April 2020 to October 2023.All subjects underwent dual-energy X-ray bone density testing and lateral lumbar X-ray examination and met the inclusion and exclusion criteria.The Kauppila calcification scoring method was used to assess the abdominal aortic calcification score (AACS). Patients were divided into two groups based on the AACS results: patients without or with mild AAC (AACS ≤ 4) and patients with moderate or severe AAC (AACS > 4). The correlation between AACS and BMD/T-scores at various sites was analyzed.Subgroup analyses were conducted based on the presence of hypertension, hyperlipidemia, renal dysfunction, and the number of comorbidities to evaluate the differences in their correlation in different groups.Results:A total of 188 postmenopausal women was enrolled in this study, with a mean age of (70.79 ± 8.82) years.Among them, 145 patients were classified in the group without or with mild AAC, and 43 patients with moderate or severe AAC.Compared with the group without or with mild AAC, the patients in the group with moderate to severe AAC had significantly lower BMD and T-scores in the femoral neck and total hip (all P<0.05). The Spearman correlation analysis revealed significantly negative correlations between AACS and T- scores in the femoral neck and total hip ( P<0.025), with even stronger correlations observed in patients with hypertension or renal dysfunction; besides, the correlation between AACS and hip BMD T-scores was even more significant in patients with hyperlipidemia, as well as those with two or more comorbidities.Multivariate logistic regression analysis indicated that AACS was an independent risk factor for decreased T-scores in the femoral neck (T<-2.5) ( OR=1.127, 95% CI: 1.030-1.234, P=0.009) and total hip (T<-2.5) ( OR=1.119, 95% CI: 1.023-1.224, P=0.014) in postmenopausal women. Conclusions:AAC is highly prevalent among postmenopausal women.Those with moderate to severe AAC tend to have lower hip BMD.AACS is significantly negatively correlated with T-scores of the femoral neck and total hip, and this result is more pronounced in patients with hypertension, hyperlipidemia, and renal dysfunction.Its correlation with the hip T-score is even more significant in patients with hyperlipidemia, as well as those with two or more comorbidities.AACS is an independent risk factor for the decline of hip BMD in postmenopausal women.