Objective To observe the efficacy of hyperbaric oxygen (HBO) in the treatment of acute carbon monoxide poisoning (ACOP),and also to analyze its treatment efficacy by various factors.Methods Four hundred and thirty-seven patients with ACOP who sought medical care in the Fujian Provincial Hospital from January 2005 to June 2014 were chosen for the study.In accordance with different treatment methods,the patients were divided into 2 groups:the control group (n =179) and the HBO group (n =258).The patients in the control group received routine medical care,while the patients in the (HBO) group received HBO treatment in addition to routine care.Medical follow-ups were made one month,6 months,1 year and 2 years after onset,and the scores of therapeutic efficacy,cure rate,efficacy rate,disability rate,death rate,as well as incidence of delayed encephalopathy were analyzed and compared between the 2 groups.Correlation analysis was made of the 21 factors affecting therapeutic efficacy of HBO for the treatment of ACOP,and multiple linear regression analysis of related factors was also made in the study.Results Medical follow-up results indicated that the cure rate and efficacy rate of the patients after 2 years of treatment were significantly better than those patients after just one month of treatment,and the disability rate was also decreased significantly.Statistical significance could be noted,when comparisons were made between the 2 groups (P ＜ 0.05).One month and 2 years after onset,the scores of therapeutic efficacy,cure rates and efficacy rates of the HBO group were ignificantly higher than those of the control group at the same time points.Disability rates,death rates and incidence of delayed encephalopathy were significantly lower than those of the control group,also with statistical significance (P ＜ 0.05).There was little effect on the scores of therapeutic efficacy and the incidence of delayed encephalopathy for those HBO patients with an age ≤30,1 month and 2 years after onset.However,HBO therapy could decrease the over-all incidence of delayed encephalopathy.There was significant correlation between the interval time of HBO retreatment and the number of HBO sessions in the incidence of delayed encephalopathy.Conclusions Various factors,such as age,pathogenic factors,symptoms after onset,the interval of emergency medical care,coma time,compliance of medical advice about HBO,medical histor.y of diabetes mellitus,duration of stay at the CO environment,the number of HBO sessions,were all important factors affecting the incidence of delayed encephalopathy.HBO therapy could produce good clinical effect on the patients with ACOP,increase cure rate and at the same time decrease the incidence of delayed encephalopathy.For this reason,it was worth further clinical extension.

Objective To observe the efficacy of hyperbaric oxygen (HBO) in the treatment of acute carbon monoxide poisoning (ACOP),and also to analyze its treatment efficacy by various factors.Methods Four hundred and thirty-seven patients with ACOP who sought medical care in the Fujian Provincial Hospital from January 2005 to June 2014 were chosen for the study.In accordance with different treatment methods,the patients were divided into 2 groups:the control group (n =179) and the HBO group (n =258).The patients in the control group received routine medical care,while the patients in the (HBO) group received HBO treatment in addition to routine care.Medical follow-ups were made one month,6 months,1 year and 2 years after onset,and the scores of therapeutic efficacy,cure rate,efficacy rate,disability rate,death rate,as well as incidence of delayed encephalopathy were analyzed and compared between the 2 groups.Correlation analysis was made of the 21 factors affecting therapeutic efficacy of HBO for the treatment of ACOP,and multiple linear regression analysis of related factors was also made in the study.Results Medical follow-up results indicated that the cure rate and efficacy rate of the patients after 2 years of treatment were significantly better than those patients after just one month of treatment,and the disability rate was also decreased significantly.Statistical significance could be noted,when comparisons were made between the 2 groups (P ＜ 0.05).One month and 2 years after onset,the scores of therapeutic efficacy,cure rates and efficacy rates of the HBO group were ignificantly higher than those of the control group at the same time points.Disability rates,death rates and incidence of delayed encephalopathy were significantly lower than those of the control group,also with statistical significance (P ＜ 0.05).There was little effect on the scores of therapeutic efficacy and the incidence of delayed encephalopathy for those HBO patients with an age ≤30,1 month and 2 years after onset.However,HBO therapy could decrease the over-all incidence of delayed encephalopathy.There was significant correlation between the interval time of HBO retreatment and the number of HBO sessions in the incidence of delayed encephalopathy.Conclusions Various factors,such as age,pathogenic factors,symptoms after onset,the interval of emergency medical care,coma time,compliance of medical advice about HBO,medical histor.y of diabetes mellitus,duration of stay at the CO environment,the number of HBO sessions,were all important factors affecting the incidence of delayed encephalopathy.HBO therapy could produce good clinical effect on the patients with ACOP,increase cure rate and at the same time decrease the incidence of delayed encephalopathy.For this reason,it was worth further clinical extension.

OBJECTIVETo analyze and summarize the characteristics and treatment of acute spinal cord decompression sickness. To explore the factors that influence the treatment effect.

METHODS77 cases of acute spinal cord decompression sickness patients should be divided into 4 groups according to the pressurized treatment and drug treatment options. They were group I, group II, group III and group IV. At the same time they were get hyperbaric oxygen therapy and other treatment. The evaluation index, were Frankel function classification and paraplegia index. There were 17 factors that affected the treatment effect.

RESULTSThe rate of early cure was 57.14% (44/77). The rate of late cure was 74.03% (57/77). Their difference was statistically significant (P<0.05). In 3 months and 1 year the cure rate of group IV and group B were the highest. But there was no difference between them(P>0.05). They were higher than group ii and group I (P<0.05). The Frankel function classification in 3months and 1 year in each group was higher than before treatment (P<0.05). The paraplegia index in 3 months and 1 year in each group was lower than before treatment (P<0.05). In 3 months and 1 year the Frankel function classification was increased gradually and the paraplegia index was decreased gradually in group I , group II, group III (P<0.05). In group IV and group III the Frankel function and the paraplegia index had not significant difference (P>0.05). Among the 17 factors that affect the treatment effect there are 9 factors that affect the proportion of the large.

CONCLUSIONSThe first choice of treatment method for the patients with acute spinal cord decompression sickness would be group III. Drug therapy was also imporpant. At the same time the hyperbaric oxygen therapy and other treatments were taken. Although the cure rate was not high in this article. But most of the cure is within 3 months. Within 1 year.the cure rate still could be improved. 9 factors that affect the efficacy of acute spinal cord decompression sickness was more noteworthy.

Decompression Sickness ; therapy ; Diving ; adverse effects ; Humans ; Hyperbaric Oxygenation ; Paraplegia ; physiopathology ; therapy ; Spinal Cord ; physiopathology

OBJECTIVETo compare the efficacy and safety of Stronger Neo-Minophagen C (SNMC) in the treatment of chronic hepatitis B.

METHODSWe searched MEDLINE, EMBASE, CBM, and CNKI up to December, 2012 to identify randomized controlled trials (RCTs) comparing Stronger Neo-Minophagen C plus other therapy versus others therapy for chronic hepatitis B. Two reviewers independently assessed the risk of bias and extracted data from the included RCTs according to the Cochrane Reviewers Handbook 5.1.0. Meta-analyses were performed using RevMan 5.1 software.

RESULTSThirty-one trials involving 2753 patients were included in the analysis. The results of meta-analyses showed that SNMC improved hepatic functions of the patients by reducing ALT (MD=-31.63, 95% CI: -51.57, -11.70), AST (MD=-18.70, 95% CI:-25.10, -12.30), TBIL (MD=-12.17, 95% CI: -17.63,-6.71), HA (MD=-94.89, 95% CI: -125.19, -64.60), LN (MD=-40.08, 95% CI: -52.38,-27.78), IV-C (MD=-50.61, 95% CI:-63.40, -37.81), PC-III (MD=-49.71, 95% CI: -71.72, -27.69) as compared with the control group. The seroconversion rate of HBeAg (OR=2.23, 95% CI: 1.70, 2.94), HBV-DNA (OR=2.20, 95% CI: 1.70, 2.84), HBsAg (OR=2.25, 95% CI: 1.24 , 4.07), total response rate (OR=4.37, 95% CI: 2.62, 7.28), and ALT normalization rate (OR=3.77, 95% CI: 2.46, 5.79) were all significantly higher in the combined therapy group than in the control group.

CONCLUSIONSNMC plus other therapy is more effective than other therapy alone in improving the hepatic function and hepatic fibrosis and increasing hepatic seroconversion rate in patients with chronic hepatitis B without causing serious adverse events. But considering the low quality of the included studies, the results should be interpreted with caution and awaits further confirmation by high-quality, large-scale RCTs.

Cysteine ; therapeutic use ; Drug Combinations ; Glycine ; therapeutic use ; Glycyrrhetinic Acid ; analogs & derivatives ; therapeutic use ; Hepatitis B Surface Antigens ; blood ; Hepatitis B e Antigens ; blood ; Hepatitis B, Chronic ; drug therapy ; Humans ; Liver Cirrhosis ; drug therapy ; Randomized Controlled Trials as Topic

Objective To build the indicators system to collect patient safety monitoring information, focusing on medical complaints. Methods With such methods as literature review and expert advice, building the system for medical complaints collection and monitoring. Such indicators are modified and improved in pilot operations. Results The framework of the medical complaint monitoring indicators system is built in five dimensions, comprising 8 grade-1 indicators including patient complaint causes and hospital cause analysis, and 20 grade-2 indicators. Conclusion These indicators are scientific and operable to detect adverse patient safety events.

BACKGROUNDTo determine the long-term efficacy and persistence of Chinese infants after receiving only active plasma-derived hepatitis B vaccine, and to evaluate if providing booster vaccination after basic hepatitis B immunization is necessary.

METHODSInfants who were born in 1986-1988 in four demonstrative hepatitis B immunization trial areas of Hunan, Guangxi, Hebei and Shanghai after receiving only active plasma-derived hepatitis B vaccination, had been randomly followed up for 15 years. HBsAg,anti-HBs and anti-HBc in 21 680 person-times were tested using commercial SPRIA kits.

RESULTSPrevalence of HBV carriers was less than 1.66% among all children vaccinated with only active plasma-derived hepatitis B vaccine in 4 clinical trial areas. Prevalence of HBsAg did not increase with years after vaccination,90%(95% Cl:83.1%-97.2%) effectiveness of hepatitis B vaccine persisted for 15 years in preventing chronic HBV infection. Carriage, HBV infection and efficacy were not different among all age groups (P>0.05). Seroprotection rate (anti-HBs?10 mIU/ml) and quantity of anti-HBs were significantly decreased with years after vaccination. Seroprotection rates of anti-HBs were 40%-50% and 30%-42% during the 9th-10th year and the 13th-14th ear of vaccination, respectively. Titer of anti-HBs declined?by 90% after 14 years.

CONCLUSIONSThese results showed that long-term efficacy of only active plasma-derived hepatitis B vaccination, which was not affected by decline in seroprotection rate and titer of anti-HBs. For children and adults whose immune status is normal, booster doses of vaccine are not recommended.

Adolescent ; Child ; Child, Preschool ; Follow-Up Studies ; Hepatitis B ; prevention & control ; Hepatitis B Antibodies ; blood ; Hepatitis B Surface Antigens ; blood ; Hepatitis B Vaccines ; immunology ; Humans ; Infant ; Infant, Newborn ; Vaccination