Objective:To analyze the clinical characteristics and treatment of eosinophilic angiocentric fibrosis (EAF) involving the orbit.Methods:We described a case and review the literature of EAF involving the orbit.Results:The literature review has shown 34 similar cases. Nineteen patients combined with other site involvement (17 cases had nasal involvement), whereas 15 had primary orbital involvement. Ocular swelling (18 cases) and epiphora (4 cases) were the most common initial presenting symptoms. The typical histopathologic findings include a perivascular, eosinophil-rich infiltrate and a "onion-skin" type of fibrosis concentrated around small vessels and all cases in this group conformed the above typical characteristics. In this series, 20 patients provided immunohistochemical results for IgG4, among them, 16 cases were positive while 4 cases were negative. No manifestations of obliterative phlebitis and storiform fibrosis were observed. The age, gender, and lesion locations (single or multiple) of the IgG4 staining positive group and the negative group were analyzed. There was no statistically significant difference in the age of onset, gender ratio and lesion the two groups ( P>0.05). Conclusion:For patients presented with ocular swelling, epiphora, with or without nasal lesions, EAF should be considered. The diagnosis of EAF is based largely on histopathologic findings. Although some cases were positive for IgG4 by immunohistochemistry, storiform fibrosis and obliterative phlebitis is not seen in our series, which aid in distinguishing EAF from IgG4-related disease.

Objective To explore adhering to 24-hour movement guidelines of disabled athletes,and its correlation to psychological resilience and subjective well-being.Methods A convenience sampling method was used to survey 192 disabled athletes from 17 provinces in China,to collect their demo-graphic information,compliance with 24-hour movement guidelines,psychological resilience and subjec-tive well-being.Ultimately,180 valid samples were obtained.Generalized linear models were used to analyze the relationship of meeting 24-hour movement guidelines to psychological resilience and subjec-tive well-being,and the roles of gender and type of disability were explored.Results On the average,disabled athletes spent 3.68 h on physical activities every week,but 4.89 h and 8 h on sedentary be-havior and sleep every day.The proportions of meeting 3 guidelines,2,and 1 were 26.1%,47.8%and 22.2%,respectively.Moreover,there was a dose-response relationship of the number of guide-lines met to psychological resilience(B=5.184,P<0.001)and subjective well-being(B=2.806,P<0.01).In other words,disabled athletes meeting more guidelines exhibited higher levels of psychological resil-ience(B=8.407,P<0.001)and subjective well-being(B=6.122,P<0.001).Conclusion Meeting 24-hour movement guidelines is of positive relation to psychological resilience and subjective well-being.There-fore,it is recommended to promote adherence to 24-hour movement guidelines among disabled ath-letes to promote their psychological health.

Objective To explore adhering to 24-hour movement guidelines of disabled athletes,and its correlation to psychological resilience and subjective well-being.Methods A convenience sampling method was used to survey 192 disabled athletes from 17 provinces in China,to collect their demo-graphic information,compliance with 24-hour movement guidelines,psychological resilience and subjec-tive well-being.Ultimately,180 valid samples were obtained.Generalized linear models were used to analyze the relationship of meeting 24-hour movement guidelines to psychological resilience and subjec-tive well-being,and the roles of gender and type of disability were explored.Results On the average,disabled athletes spent 3.68 h on physical activities every week,but 4.89 h and 8 h on sedentary be-havior and sleep every day.The proportions of meeting 3 guidelines,2,and 1 were 26.1%,47.8%and 22.2%,respectively.Moreover,there was a dose-response relationship of the number of guide-lines met to psychological resilience(B=5.184,P<0.001)and subjective well-being(B=2.806,P<0.01).In other words,disabled athletes meeting more guidelines exhibited higher levels of psychological resil-ience(B=8.407,P<0.001)and subjective well-being(B=6.122,P<0.001).Conclusion Meeting 24-hour movement guidelines is of positive relation to psychological resilience and subjective well-being.There-fore,it is recommended to promote adherence to 24-hour movement guidelines among disabled ath-letes to promote their psychological health.

Objective:To analyze the clinical characteristics and treatment of eosinophilic angiocentric fibrosis (EAF) involving the orbit.Methods:We described a case and review the literature of EAF involving the orbit.Results:The literature review has shown 34 similar cases. Nineteen patients combined with other site involvement (17 cases had nasal involvement), whereas 15 had primary orbital involvement. Ocular swelling (18 cases) and epiphora (4 cases) were the most common initial presenting symptoms. The typical histopathologic findings include a perivascular, eosinophil-rich infiltrate and a "onion-skin" type of fibrosis concentrated around small vessels and all cases in this group conformed the above typical characteristics. In this series, 20 patients provided immunohistochemical results for IgG4, among them, 16 cases were positive while 4 cases were negative. No manifestations of obliterative phlebitis and storiform fibrosis were observed. The age, gender, and lesion locations (single or multiple) of the IgG4 staining positive group and the negative group were analyzed. There was no statistically significant difference in the age of onset, gender ratio and lesion the two groups ( P>0.05). Conclusion:For patients presented with ocular swelling, epiphora, with or without nasal lesions, EAF should be considered. The diagnosis of EAF is based largely on histopathologic findings. Although some cases were positive for IgG4 by immunohistochemistry, storiform fibrosis and obliterative phlebitis is not seen in our series, which aid in distinguishing EAF from IgG4-related disease.

Objective:Using atenolol as a model drug,the aim of this study was to develop a sustained and controlled transdermal drug delivery system(TDDS)based on polyethyleneimine-modified MoS2 nanoparticles(PEI-MoS2 NPs)that were responsive to near infrared(NIR)laser irradiation.Methods:The three-dimensional flower-like PEI-MoS2 NPs were successfully synthesized and further characterized by attenuated total reflection Fourier transform infrared spectroscopy,X-ray diffraction measurements,scanning electron microscopy,and transmission electron microscopy.The controlled release capacity of PEI-MoS2 NPs was examined using in vitro drug release and skin penetration experiments.Results:The PEI-MoS2 NPs exhibited a drug loading efficiency of 53.86% and high photothermal conversion ability.Moreover,the release of atenolol was enhanced by NIR stimulation with an enhancement ratio of 1.56.Conclusion:NIR-controlled PEI-MoS2 NPs was essential for the control and sustained release of drugs in TDDS.