In recent years,Mendelian randomization based on Genome-wide association study has been widely applied to explore the etiology of various diseases.The method utilizes genetic variants strongly associated with risk factors as instrumental variables to investigate the causal relationship between exposure factors and outcome indicators.This paper reviews the progress of Mendelian randomization in the study of migraine,aiming to provide reference for the research on the mechanisms,diagnosis,treatment,and prevention of migraine.

With the continuous advancement of diagnostic technologies, the detection rate of thyroid nodules in the population is steadily increasing. Diagnosis primarily relies on the Thyroid Imaging Reporting and Data System (TIRADS) and fine needle aspiration biopsy (FNAB) of thyroid nodules. High-resolution ultrasound is the most important imaging modality for diagnosing thyroid nodules, offering advantages such as convenience, flexibility, non-invasiveness, and no radiation. Ultrasound-guided fine needle aspiration biopsy is the most accurate and effective method for preoperative diagnosis of thyroid nodules. Artificial intelligence (AI), a branch of computer science, aims to enable machines to simulate or perform cognitive functions similar to human intelligence. AI is gradually being applied in the medical field and has gained significant attention in the diagnosis of thyroid nodules, significantly improving the efficiency and accuracy of diagnosis. This article will explore the research progress and application value of AI in the diagnosis of thyroid nodules from aspects such as thyroid nodule ultrasound imaging and cytopathology. The goal is to summarize the latest advancements in AI for the diagnosis of thyroid nodules, assist clinicians in understanding the current state of the field, and provide more accurate and comprehensive reference information for clinical decision-making in the diagnosis and treatment of thyroid nodules.

In recent years,Mendelian randomization based on Genome-wide association study has been widely applied to explore the etiology of various diseases.The method utilizes genetic variants strongly associated with risk factors as instrumental variables to investigate the causal relationship between exposure factors and outcome indicators.This paper reviews the progress of Mendelian randomization in the study of migraine,aiming to provide reference for the research on the mechanisms,diagnosis,treatment,and prevention of migraine.

Background: and Purpose To examine the clinical and safety outcomes after endovascular treatment (EVT) for acute basilar artery occlusion (BAO) with different anesthetic modalities. Methods: This was a retrospective analysis using data from the Endovascular Treatment for Acute Basilar Artery Occlusion (ATTENTION) registry. Patients were divided into two groups defined by anesthetic modality performed during EVT: general anesthesia (GA) or non-general anesthesia (non-GA). The association between anesthetic management and clinical outcomes was evaluated in a propensity score matched (PSM) cohort and an inverse probability of treatment weighting (IPTW) cohort to adjust for imbalances between the two groups. Results: Our analytic sample included 1,672 patients from 48 centers. The anesthetic modality was GA in 769 (46.0%) and non-GA in 903 (54.0%) patients. In our primary analysis with the PSM-based cohort, non-GA was comparable to GA concerning the primary outcome (adjusted common odds ratio [acOR], 1.01; 95% confidence interval [CI], 0.82 to 1.25; P=0.91). Mortality at 90 days was 38.4% in the GA group and 35.8% in the non-GA group (adjusted risk ratio, 0.95; 95% CI, 0.83 to 1.08; P=0.44). In our secondary analysis with the IPTW-based cohort, the anesthetic modality was significantly associated with the distribution of modified Rankin Scale at 90 days (acOR: 1.45 [95% CI: 1.20 to 1.75]). Conclusion In this nationally-representative observational study, acute ischemic stroke patients due to BAO undergoing EVT without GA had similar clinical and safety outcomes compared with patients treated with GA. These findings provide the basis for large-scale randomized controlled trials to test whether anesthetic management provides meaningful clinical effects for patients undergoing EVT.