Objective The development status,hot spots and trends of traditional Chinese medicine in the treatment of multiple sclerosis(MS)were analyzed by bibliometric and visual analysis.Methods Literatures related to the treatment of MS by traditional Chinese medicine were searched from CNKI,Wanfang Data and VIP from January 2000 to July 2024.CiteSpace software was used to visually analyze the number of publications,authors,institutions and key words in relevant literatures.Results A total of 438 literatures were included,and the number of published literatures showed an overall increasing trend.Fan Yongping pubilshed the most papers.The research institutions were mainly Dongzhimen Hospital of Beijing University of Chinese Medicine and Beijing Tiantan Hospital Affiliated to Capital Medical University.The current high-frequency key words in this field included acupuncture,treatment based on syndrome differentiation,traditional Chinese medicine,etc.A total of 9 clusters were formed."Acupuncture"was the most prominent.Conclusion Scholars have carried out active exploration and research in the field of traditional Chinese medicine in the treatment of MS,and the overall development trend is good.The research hot spots include acupuncture,treatment based on syndrome differentiation,traditional Chinese medicine,etc.,and the etiology and pathogenesis may be the future research trend.

Objective The development status,hot spots and trends of traditional Chinese medicine in the treatment of multiple sclerosis(MS)were analyzed by bibliometric and visual analysis.Methods Literatures related to the treatment of MS by traditional Chinese medicine were searched from CNKI,Wanfang Data and VIP from January 2000 to July 2024.CiteSpace software was used to visually analyze the number of publications,authors,institutions and key words in relevant literatures.Results A total of 438 literatures were included,and the number of published literatures showed an overall increasing trend.Fan Yongping pubilshed the most papers.The research institutions were mainly Dongzhimen Hospital of Beijing University of Chinese Medicine and Beijing Tiantan Hospital Affiliated to Capital Medical University.The current high-frequency key words in this field included acupuncture,treatment based on syndrome differentiation,traditional Chinese medicine,etc.A total of 9 clusters were formed."Acupuncture"was the most prominent.Conclusion Scholars have carried out active exploration and research in the field of traditional Chinese medicine in the treatment of MS,and the overall development trend is good.The research hot spots include acupuncture,treatment based on syndrome differentiation,traditional Chinese medicine,etc.,and the etiology and pathogenesis may be the future research trend.

Ischemic cerebrovascular disease(ICVD)refers to the degeneration,necrosis,or transient loss of function of local brain tissue due to blood supply disorders,and is one of the common neurological diseases.Exosomes are a subgroup of extracellular vesicles,characterized by good biocompatibility,low toxicity and immunogenicity,and strong designability.The components of exosomes include proteins,lipids,genetic materials,etc.They come from a wide range of sources and can be secreted by various cells under physiological or pathological conditions.The roles and related mechanisms of exosomes from different sources in the treatment of ICVD are different.This article reviews the therapeutic effects and related mechanisms of exesomes derived from mesenchymal stem cells,brain cells,blood,endothelial cells,and macrophages on ICVD,in order to provide reference for the clinical treatment of ICVD.