BackgroundDue to the COVID-19 pandemic， both teenagers' studies and personal life are critically affected， which has resulted in a variety of mental health problems. In this regard， scholars at home and abroad have carried out a large number of research concerning adolescent mental health， of which there still exists a lack of systematic combing and review. ObjectiveTo understand the status and development trend of research on adolescent mental health during the COVID-19 pandemic at home and abroad， and to grasp the current research hotspots and trends in this field， so as to provide references for relevant research and practice in the post-epidemic era. MethodsOn October 30， 2022， we searched through China Knowledge Network Infrastructure （CNKI） and Web of Science database， and the publishing time of articles to be retrieved was limited between December 1， 2019 and October 30， 2022. Excel and CiteSpace were used to perform visual analysis on these articles in terms of number， author， institution， country and keywords of the articles. ResultsA total of 7 608 articles were included. At home and abroad， the number of papers related to adolescent mental health generally increased at first and then decreased under the pandemic situation. Compared with foreign countries， the connection and cooperation among domestic scholars and institutions was not close enough. The top three countries in the number of English literature published were the United States， Britain and China， and those in intermediary center were Tunis， Cameroon and Anguilla. The parent-child relationship and mental health of teenagers during were much concerned by scholars both at home and abroad. With the passage of time， researchers at home and abroad had shifted their focus from only negative factors to positive factors. ConclusionChinese scholars or institutions need to strengthen more domestic and international exchanges and cooperation. Scholars from different countries can carry out cross-cultural study on research topics of common concern， and continue to explore the positive psychological changes of teenagers in the post-epidemic era.［Funded by National Social Science Foundation 2020 Education Youth Project of 13th Five-Year Plan （number， CHA200259）］

Objective::This study aimed to evaluate the major adverse cardiovascular and cerebrovascular events (MACCEs) and overall safety profile associated with iodixanol in Chinese patients undergoing percutaneous coronary intervention (PCI).Methods::Patients at 30 centers in China registered in the OpenClinic v3.6 database from October 30, 2013, to October 7, 2015, were included in the study. The primary endpoint was in-hospital MACCEs including target lesion revascularization (TLR), stroke, stent thrombosis, cardiac death, and PCI-related myocardial infarction (MI) within 72 h post-PCI. Secondary endpoints were MACCEs from 72 h to 30 d post-PCI and other safety events within 30 d post-PCI.Results::A total of 3,042 patients were enrolled. The incidence of MACCEs within 72 h post-PCI was 2.33% ( n = 71), including cardiac death (0.03%, n = 1) and PCI-related MI (2.30%, n = 70). The incidence of MACCEs from 72 h to 30 d post-PCI was 0.16% ( n = 5), including cardiac death (0.10%, n = 3), PCI-related MI (0.03%, n = 1), and TLR for stent thrombosis (0.03%, n = 1). The incidence of composite angiographic or procedural complications was 2.86% ( n = 87); 233 (7.86%) patients had results suggesting contrast-induced acute kidney injury. Conclusions::These findings indicate that the use of iodixanol in Chinese patients undergoing PCI is associated with a low incidence of MACCEs, confirming its safety in this population.

Objective::This study aimed to evaluate the major adverse cardiovascular and cerebrovascular events (MACCEs) and overall safety profile associated with iodixanol in Chinese patients undergoing percutaneous coronary intervention (PCI).Methods::Patients at 30 centers in China registered in the OpenClinic v3.6 database from October 30, 2013, to October 7, 2015, were included in the study. The primary endpoint was in-hospital MACCEs including target lesion revascularization (TLR), stroke, stent thrombosis, cardiac death, and PCI-related myocardial infarction (MI) within 72 h post-PCI. Secondary endpoints were MACCEs from 72 h to 30 d post-PCI and other safety events within 30 d post-PCI.Results::A total of 3,042 patients were enrolled. The incidence of MACCEs within 72 h post-PCI was 2.33% ( n = 71), including cardiac death (0.03%, n = 1) and PCI-related MI (2.30%, n = 70). The incidence of MACCEs from 72 h to 30 d post-PCI was 0.16% ( n = 5), including cardiac death (0.10%, n = 3), PCI-related MI (0.03%, n = 1), and TLR for stent thrombosis (0.03%, n = 1). The incidence of composite angiographic or procedural complications was 2.86% ( n = 87); 233 (7.86%) patients had results suggesting contrast-induced acute kidney injury. Conclusions::These findings indicate that the use of iodixanol in Chinese patients undergoing PCI is associated with a low incidence of MACCEs, confirming its safety in this population.

Objective To study the clinical characteristics and risk factors of elderly female CHD patients.Methods A total of 1223elderly CHD patients(493females and 730males)were included in this study.Their general clinical data and inhospital mortality were retrospectively analyzed and the risk factors for their inhospital mortality were analyzed.Results The age was significantly older,the incidence of DM,hyperlipidemia,sleep apnea sysdrome and the ratio of divorce and widowhood were significantly higher while the number of smokers and alcohol drinkers was significantly smaller in female patients than in male patients.The serum levels of LDL-C,TC,TG,FPG,apoA-Ⅰ,apoB were significantly higher,the specific volume of RBC was significantly larger while the number of RBC was significantly smaller,the serum Hb,CK-MB,EOS,Hcy,TBA,TBIL,APTT levels were significantly lower in female patients than in male patients.No significant difference was detected in inhospital mortality between female and male patients(6.7％vs 5.9％,P＞0.05).The low glomerular filtration rate was an independent predictor of inhospital mortality in elderly female patients(HR=0.894,95％CI:0.808-0.990,P=0.031)while age and serum creatine kinase isozyme level were the risk factors for inhospital mortality in elderly male patients( HR=1.169,95％CI:1.013-1.350,P=0.033;HR=1.008,95％CI:1.002-1.013,P=0.006).Conclusion The age of elderly female CHD patients is older than that of elderly male CHD patients.The spectrum of risk factors is significantly different between elderly female and male CHD patients.It is thus necessary to further study its prognostic value.

Objective: To investigate the effect of obstructive sleep apnoea-hypoapnoea syndrome(OSAHS)on diabetic retinopathy(DR)in elderly patients with type 2 diabetes mellitus(T2DM)and analyze risk factors for DR process. Methods: Data of elderly diabetic patients without DR admitted into our hospital from January 2012 to December 2014 were retrospectively analyzed.Based on whether or not to combine OSAHS, patients were divided into the OSAHS group(n=42)and the control group(n=85). After 36 months' follow-up, the incidence and progression of DR were compared, and the effect of different degree of OSAHS on DR was analyzed.Multivariate logistic regression analysis was used to analyze the risk factors for DR. Results: The systolic pressure, diastolic pressure and Epworth sleepiness scores were higher in the OSAHS group than in the control group(P<0.05). At the(34.5±6.7)months of follow-up versus baseline, body mass index, renal function and cardiac function were markedly decreased in both groups(P<0.05). The systolic pressure, diastolic pressure, 2-h postprandial blood glucose and Epworth sleepiness scores were higher in the OSAHS group than in the control group; and the glomerular filtration rate(GFR)and left ventricular ejection fraction were lower in the OSAHS group than in the control group(P<0.05). The incidences of mild, moderate and severe non-proliferative DR were higher in the OSAHS group than in the control group(P<0.05). The results of subgroup analysis showed that the incidence of DR was higher in patients with moderate to severe OSAHS than in controls(OR=4.57, 95%CI: 1.24~13.78, P=0.002), while the incidence of DR in patients with mild OSAHS was similar to that in the controls(OR=2.33, 95%CI: 0.66~12.56, P=0.29). Multivariate logistic regression analysis showed that T2DM duration ≥7 years(OR=3.24, 95%CI: 1.80-9.59, P<0.05), haemoglobin A1c(HbA1c)≥7.5%(OR=2.07, 95%CI: 1.41-8.52, P<0.05), GFR<60 ml/min(OR=4.52, 95%CI: 1.75-14.26, P<0.05)and apnea/hyponea index ≥15/h(OR=2.03, 95%CI: 1.37-11.24, P<0.05)were independent risk factors for DR. Conclusions OSAHS patients tend to have hypertension and high glucose level, and are more prone to cardiac and renal dysfunction and DR.T2DM duration ≥7 years, HbA1c ≥7.5%, GFR<60 ml/min and AHI ≥15/h are independent risk factors for DR progression.And more studies are needed to confirm the independent risk factors.

Objective To assess the feasibility,safety and efficacy of primary PCI in elderly patients with AMI.Methods Three hundred and sixty-four AMI patients were divided into ≥75 years old group (n=90) and ＜75 years old group (n=274).The successful operation rate,preoperative complication rate,mortality and incidence of major adverse cardiovascular events (MACE) were recorded during their hospital stay time.Results The successful operation rate was 94.4％,the postoperative TIMI 3 blood flow rate was 87.8％,and the preoperative complication rate was 10.0 ％ in ≥75 years old group.The mortality and incidence of MACE were significantly higher in ≥75 years old group than in＜75 years old group during the hospital stay time (12.2％ vs 2.9％,P =0.001;16.7 ％ vs 5.1％,P =0.000).Conclusion Transradial primary PCI is a safe,feasible and effective therapy for ≥75 years old AMI patients.

Objective To assess the safety of PCI and risk of death in ≥85 years old patients.Methods Ninety ≥85 years old coronary heart disease patients after PCI were included in this study.The risk of death on day 30 after PCI and during the follow-up period was assessed according to their surgical access,preoperative and postoperative estimated glomerular filtration rate (eGFR) and bleeding events,NCDR risk score of CHD.The patients were followed up for 693±510 days.Results Eighty-four patients (93.3％) underwent PCI via the radial artery.The dose of contrast media was 128.3±55.8 ml.No significant difference was found in preoperative and postoperative eGFR (55.53 ± 19.58 ml/min · 1.73 m2 vs 55.40± 18.84 ml/min · 1.73 m2,t =0.095,P=0.925).Bleeding occurred in 4 patients (4.4％) with no life-threatening massive bleeding occurred.The risk of death increased in patients with their NCDR risk score ＞45 on day 30 after PCI (P=0.013).Conclusion PCI is a safe and feasible procedure and NCDR risk score can predict the risk of death in ≥85 years old patients on day 30 after PCI.

Objective To analyze autonomic nervous function in the crew of a large surface ship.Methods Dynamic 24-hour Holter monitoring was performed in 157 afloat naval personnel at sea.Heart rate variability (HRV)and deceleration capacity of heart rate (DC) were analyzed off-line,and differences in the detected data were compared between naval personnel working or performing tasks at different departments or decks,or working at different hours.Then,the correlation between different working hours and HRV and DC was analyzed statistically.Results HRV standard deviation (SDNN) [(168.57 ± 28.02) ms] of the naval personnel in the mechanical and electrical department within 24 hours,SDANN every 5 minutes within 24 hours [(151.79 ± 28.59)ms],RMSSD within the 2 adjacent cardiac cycles in the whole course [(39.21 ± 11.44) ms],the percentage of PNN50 within the 2 adjacent cardiac cycles greater than 50 ms [(15.45 ± 8.09)％],high frequency (HF) [(548.18 ±329.27) ms2],and the data of SDNN [(168.93 ±26.97)ms],RMSSD [(41.06± 13.91)ms],PNN50[(17.45 ±8.58)％] and DC [(7.35 ±2.08)ms] in the ship husbandry department were all lower than those of the medical department and administrative department [SDNN (183.87 ± 42.50) ms,SDANN (166.40 ± 43.07) ms,RMSSD (49.78 ± 17.74) ms,PNN50 (21.94 ± 11.16) ％,HF (806.93 ± 603.37) ms2 and DC (8.11 ± 1.43) ms].Statistical significance could be noted,when comparisons were made between them(P ＜ 0.05 or P ＜ 0.01).However,there was no statistical significance in HRV and DC,when comparisons were made between the naval personnel working on the top surface deck and below the surface deck(P ＞0.05).The data of RMSSD,PNN50,HF andDC during deployment were lower than those before deployment (P ＜ 0.05).The length of afloat naval service [(39 ± 29) months] was negatively correlated with SDNN,SDANN,RMSSD,PNN50,HF and LF(P ＜ 0.05).Conclusions The working environment on the surface ship and deployment at sea could devastate autonomic nervous function of the crew.There existed certain extent of the injury in naval personnel working at different departments and correlation could be seen between the extent of injury and length of afloat naval service onboard the ship.

Objective To analyze autonomic nervous function in the crew of a large surface ship.Methods Dynamic 24-hour Holter monitoring was performed in 157 afloat naval personnel at sea.Heart rate variability (HRV)and deceleration capacity of heart rate (DC) were analyzed off-line,and differences in the detected data were compared between naval personnel working or performing tasks at different departments or decks,or working at different hours.Then,the correlation between different working hours and HRV and DC was analyzed statistically.Results HRV standard deviation (SDNN) [(168.57 ± 28.02) ms] of the naval personnel in the mechanical and electrical department within 24 hours,SDANN every 5 minutes within 24 hours [(151.79 ± 28.59)ms],RMSSD within the 2 adjacent cardiac cycles in the whole course [(39.21 ± 11.44) ms],the percentage of PNN50 within the 2 adjacent cardiac cycles greater than 50 ms [(15.45 ± 8.09)％],high frequency (HF) [(548.18 ±329.27) ms2],and the data of SDNN [(168.93 ±26.97)ms],RMSSD [(41.06± 13.91)ms],PNN50[(17.45 ±8.58)％] and DC [(7.35 ±2.08)ms] in the ship husbandry department were all lower than those of the medical department and administrative department [SDNN (183.87 ± 42.50) ms,SDANN (166.40 ± 43.07) ms,RMSSD (49.78 ± 17.74) ms,PNN50 (21.94 ± 11.16) ％,HF (806.93 ± 603.37) ms2 and DC (8.11 ± 1.43) ms].Statistical significance could be noted,when comparisons were made between them(P ＜ 0.05 or P ＜ 0.01).However,there was no statistical significance in HRV and DC,when comparisons were made between the naval personnel working on the top surface deck and below the surface deck(P ＞0.05).The data of RMSSD,PNN50,HF andDC during deployment were lower than those before deployment (P ＜ 0.05).The length of afloat naval service [(39 ± 29) months] was negatively correlated with SDNN,SDANN,RMSSD,PNN50,HF and LF(P ＜ 0.05).Conclusions The working environment on the surface ship and deployment at sea could devastate autonomic nervous function of the crew.There existed certain extent of the injury in naval personnel working at different departments and correlation could be seen between the extent of injury and length of afloat naval service onboard the ship.

Objective To investigate the effects of microRNA-486 (miR-486) expression on the cardiac function in rats with myocardial infarction (MI),through direct injection of an adenovirus carrying the miR-486 gene into the myocardium.Methods Totally 120 male rots were divided into 4 groups.Different target materials were infused into the surrounding areas of MI after building a successful disease model.Expression of miR-486 in the surrounding areas of left ventricular MI was detected using real-time PCR at different time points.Cardiac function was measured by cardiac ultrasound at 4 weeks.Using TUNEL,TTC,Masson,and CD31 staining to measure the organic changes in heart tissues.Results The expression of miR-486 in miR-486 group was higher than the other three groups.The expression of miR-486 in the three groups decreased when the time of MI in rats was prolonged.The cardiac function of the miR-486 group was better than that of the MI and AD groups.The MI area in the miR-486 group was smaller than that in the other two groups.Compared to the Sham group,the CVF at the infarct border zone was increased in the MI,Ad,and miR-486 groups.The AI in the MI and Ad groups was significantly increased compared to that in the miR-486 group.MVD was increased in the miR-486 group compared to that in the Sham,MI,and Ad groups.Conclusion miR-486 improved the cardiac function after MI in rats,through lightening collagen deposition,inhibiting apoptosis,and inducing angiogenesis in ischemic regions.