ObjectiveTo investigate the status of tooth loss in people aged 50 and above, so as to understand their oral health status and provide scientific evidences for promoting oral health of middle-aged and elderly people. MethodsA total of 400 patients who visited the department of stomatology at Sijing Hospital in Songjiang District of Shanghai were performed oral health examinations and their information was collected according to the national epidemiological survey standards for oral health. ResultsThere were statistically significant differences in tooth loss among people aged 50 and above with different ages, educational levels, occupations, types of medical insurance and chronic diseases (P<0.05), but gender and monthly income had no statistically significant correlations with tooth loss (P>0.05). Among lifestyle factors, smoking, alcohol consumption and tea drinking had no statistically significant impacts on the number of remaining teeth (P>0.05), but toothbrushing frequency, flossing frequency, toothpick use frequency, toothbrush replacement frequency, and tooth loosening were statistically associated with the number of remaining teeth (P<0.05). Multiple linear regression analyses indicated that a total of 7 related factors including age, educational level, occupation, medical payment type, chronic disease, tooth loosening and toothpick use frequency were significantly associated with the number level of remaining teeth in individuals aged 50 and above. ConclusionAge, chronic disease, and tooth loosening were influencing factors affecting the number of teeth left in people aged 50 and above. It is recommended to strengthen oral health education and improve healthcare awareness to reduce the risk of tooth loss in people aged 50 and above.

Objective To investigate the predictive value of preoperative systemic inflammatory response index(SIRI)combined with clinicopathological parameters for postoperative recurrence in cervical cancer and to construct a prognostic model in order to optimize recurrence risk assessment.Methods Patients with cervical cancer who underwent standard surgical treatment at the First Affiliated Hospital of Chongqing Medical University(training cohort,n=996)and Chongqing Maternal and Child Health Hospital(validation cohort,n=496)between January 2017 and January 2022 were retrospectively enrolled based on our strict inclusion and exclusion criteria.Univariate and multivariate Cox regression analyses were performed to identify independent prognostic factors for recurrence-free survival(RFS),and then a nomogram was constructed.Receiver operating characteristic(ROC)curve was plotted to assess the predictive performance of the model,and the area under the curve(AUC)and calibration curve were employed to evaluate the model.Kaplan-Meier survival analysis was performed to determine the clinical application.Results Cox regression analysis demonstrated that International Federation of Gynecology and Obstetrics(FIGO)stage(P<0.001),tumor size(P<0.001),pathological type(P<0.001),tumor grade(P=0.007),parametrial invasion(P<0.001),depth of myometrial invasion(P=0.019),lymphovascular space invasion(P=0.019),vaginal margin involvement(P=0.010),adjuvant therapy(P=0.012),and SIRI(P<0.001)were independent prognostic factors for RFS.Our nomogram model based on above prognostic factors exhibited superior predictive performance for 1-,3-,and 5-year RFS,with a significantly higher AUC value(0.886)than those of single-parameter models.Conclusion Our nomogram model demonstrated good accuracy in predicting RFS in cervical cancer patients,providing a potential tool for personalized clinical decision-making in recurrence risk management.

AIM:To observe the clinical efficacy of vitrectomy at different times for open ocular trauma and explore the timing of stage Ⅱ vitrectomy.METHODS: Retrospective case series study. A total of 60 cases(60 eyes)with open ocular trauma who visited our ophthalmology department from June 2022 to February 2023 were included. They were divided into treatment group A(interval ≤14 d)and treatment group B(interval >14 d)based on the interval between the stage Ⅰ emergency treatment surgery and the stage Ⅱ vitreoretinal surgery. Among the 32 cases(32 eyes)in the treatment group A, 16 eyes(50%)had eyeball rupture, 13 eyes(41%)had penetrating injury, and 3 eyes(9%)had perforating injury. Among the 28 cases(28 eyes)in the treatment group B, 15 eyes(54%)had eyeball rupture, 12 eyes(43%)had penetrating injury, and one eye(4%)had perforating injury. The two groups of patients were followed-up for 6 mo after surgery, and the treatment effects were compared.RESULTS:There was no statistically significant difference in visual acuity between the two groups of patients before vitrectomy(P>0.05). In the treatment group A, 10 eyes(31%)had significantly improved visual acuity, 21 eyes(66%)had effectively enhanced visual acuity, and 1 eye(3%)had no improvement in visual acuity at 6 mo after surgery. Among the 28 eyes in the treatment group B, 5 eyes(18%)had significantly improved vision, 16 eyes(57%)had effectively enhanced vision, and 7 eyes(25%)had no change in vision, with statistically significant difference between the two groups(U=322.5, P=0.032). There was no significant difference between the treatment group A and the treatment group B in complications such as secondary glaucoma, silicone oil dependence, vitreous hemorrhage, and eyeball atrophy(P>0.05). There was no evidence of traumatic proliferative vitreoretinopathy(TPVR)in the treatment group A during postoperative follow-up, which was significantly lower than that of the treatment group B(P<0.05).CONCLUSION:The prognosis of the stage Ⅱ vitrectomy for open ocular injury is relatively good after completing the stage Ⅰ surgery within 2 wk.

AIM:To summarize the clinical features and prognostic factors of patients with open ocular trauma in northwest China, and to explore the application of ocular trauma score(OTS)in open ocular trauma.METHODS:The clinical data of 91 patients(91 eyes)with open ocular trauma admitted to Xijing Hospital from June 2021 to June 2023 were retrospectively analyzed. The correlation analysis of visual acuity prognosis was carried out by age, treatment time, initial visual acuity, trauma zone and other factors, and the relationship between different OTS and prognostic visual acuity was discussed.RESULTS:Univariate analysis showed that age(0-20 years), treatment time(<24 h), initial visual acuity, trauma zone, trauma type(penetrating injury), anterior chamber hematoma, vitreous hematoma were correlated with prognostic visual acuity(all P<0.1); multivariate Logistic regression analysis showed that initial visual acuity and treatment time(<24 h)were risk factors(both P<0.05). There was a significant correlation between different OTS and prognostic visual acuity(rs=0.639,P<0.001).CONCLUSION:Patients with open ocular trauma should be diagnosed and treated as early as possible. The main factors influencing the visual prognosis are age, treatment time, initial visual acuity, trauma zone, trauma type, anterior chamber hematoma and vitreous hematoma. OTS has good application value in visual acuity evaluation of open ocular trauma prognosis.

Objective To investigate the inhibition of gigantol on corneal neovascularization(CNV)in rats after corneal alkali burn.Methods Animal models of corneal alkali burn were made with SD rats,which were divided into normal control group,model control group,low-concentration gigantol group,high-concentration gigantol group and aflibercept group,with 10 rats in each group.The rats in low-concentration gigantol group,high-concentration gigantol group and aflibercept group were treated with 2.5 mg/0.05 mL gigantol,5 mg/0.05 mL gigantol,and 2 mg/0.05 mL aflibercept by subconjunctival injection after modeling.The CNV,corneal opacity score,and thickness of the cornea were observed and compared on the 3rd,7th,and 14th days after alkali burn.The ratio of CNV area to corneal area was calculated.On the 14th day,all rats were sacrificed.Hematoxylin and eosin staining and immunohistochemistry were used to detect the expression of CD34 and VEGF.The protein expression of VEGF,IL-1β,and TNF-α was detected by ELISA.Results On the 7th and 14th days after alkali burn,the percentages of CNV to total corneal area in low-concentration gigantol group,high-concentration gigantol group and aflibercept group were significantly smaller than those in model control group(all P＜0.05).On the 14th day,the corneal opacity score was lower in high-concentration gigantol group than model control group(P＜0.05).The corneal thickness in model control group and low-concentration gigantol group were significantly greater than that in normal control group(all P＜0.001).However,the corneal thickness in high-concentration gigantol group and aflibercept group were not significantly different from that in normal control group(all P＞0.05).In addition,the protein expression of VEGF,IL-1β,and TNF-α in corneal tissues in low-concentration gigantol group,high-concentration gigantol group and aflibercept group were significantly lower than that in model control group(all P＜0.01).Conclusions Gigantol administration by subconjunctival injection can inhibit the formation of CNV in rats after alkali burn and promote absorption of the corneal edema.

Patients with severe trauma require an extremely timely treatment and transfusion plays an irreplaceable role in the emergency treatment of such patients. An increasing number of evidence-based medicinal evidences and clinical practices suggest that patients with severe traumatic bleeding benefit from early transfusion of low-titer group O whole blood or hemostatic resuscitation with red blood cells, plasma and platelet of a balanced ratio. However, the current domestic mode of blood supply cannot fully meet the requirements of timely and effective blood transfusion for emergency treatment of patients with severe trauma in clinical practice. In order to solve the key problems in blood supply and blood transfusion strategies for emergency treatment of severe trauma, Branch of Clinical Transfusion Medicine of Chinese Medical Association, Group for Trauma Emergency Care and Multiple Injuries of Trauma Branch of Chinese Medical Association, Young Scholar Group of Disaster Medicine Branch of Chinese Medical Association organized domestic experts of blood transfusion medicine and trauma treatment to jointly formulate Chinese expert consensus on blood support mode and blood transfusion strategies for emergency treatment of severe trauma patients ( version 2024). Based on the evidence-based medical evidence and Delphi method of expert consultation and voting, 10 recommendations were put forward from two aspects of blood support mode and transfusion strategies, aiming to provide a reference for transfusion resuscitation in the emergency treatment of severe trauma and further improve the success rate of treatment of patients with severe trauma.

Non-alcoholic fatty liver disease(NAFLD)is a metabolic syndrome caused by a variety of pathogenic factors and characterized by the excessive deposition of fat in liver cells.At present,the pathogenesis of NAFLD is not fully understood,and there is a lack of specific drugs for NAFLD in clinical practice.Therefore,the establishment of an ideal animal model is extremely important for clarifying the pathogenesis of NAFLD and developing specific drugs and treatments.In addition to NAFLD animal models,an increasing number of disease-syndrome combined models related to NAFLD has emerged with the continuous renewal and development of traditional Chinese medicine over the past five years.This article summarizes the NAFLD animal models commonly used within the past five years,as well as their preparation and evaluation method,to provide a reference for future studies in NAFLD animal model preparation and modeling a combination of disease and syndrome.

Objective:To analyze the current status of routine supervision by the discipline inspection departments of public hospitals and the existing problems, and discussion of countermeasures, in order to provide reference for improving the supervision and management of discipline inspection.Methods:In January 2023, 19 full-time discipline inspection cadres from Beijing municipal public hospitals were selected as the subjects of the investigation. A self-made questionnaire was used, and the survey was conducted through the Questionnaire Star platform to understand the current status of routine supervision by discipline inspection departments in various public hospitals, with descriptive analysis of the questionnaire data. From October to December 2023, 12 full-time discipline inspection cadres from 8 Beijing municipal public hospitals were selected as interview subjects. Face-to-face interviews were conducted on how to effectively carry out routine supervision and how to utilize the roles of discipline committee members and branch discipline inspection committee members, with Colaizzi′s seven-step method used to analyze the interview data.Results:41 valid questionnaires were collected. The results showed that the routine supervision matters mainly involved political supervision and supervision of key links in the operation of power, including the implementation of the Central Eight Regulations and their detailed rules (40 people, 97.6%), the selection and appointment of cadres (40 people, 97.6%), the execution of party discipline by party members and leading cadres (39 people, 95.1%), and the implementation of significant decisions and deployments by the state, Beijing municipal and higher-level departments (38 people, 92.7%), etc.; routine supervision was mainly carried out through meeting supervision (41 people, 100.0%), collaborative supervision (41 people, 100.0%), special supervision (40 people, 97.6%), and letter and visit supervision (40 people, 97.6%); the weakness in routine supervision mainly included insufficient supervision of the party committee at the same level (29 people, 70.7%), etc. The lack of information technology means such as " internet" and " big data" (26 people, 63.4%), insufficient professional knowledge training for discipline inspection cadres and lack of professional personnel (26 people, 63.4%), insufficient supervision capabilities of discipline inspection cadres (26 people, 63.4%), limited methods of routine supervision (26 people, 63.4%), and insufficient innovation in supervision methods (26 people, 63.4%) had affected the effectiveness of routine supervision. Analysis of the interview materials yielded five themes: building a supervision system, grasping the key content of routine supervision, optimizing the methods of routine supervision, enriching the paths of supervision, and strengthening the construction of integrity culture and discipline inspection cadres.Conclusions:The routine supervision efficiency of the discipline inspection departments in Beijing municipal public hospitals still needs to be further improved. It is recommended to further improve the relevant work from the aspects of strengthening the construction of the discipline inspection supervision system, enhancing the efficiency of discipline inspection supervision, reinforcing information technology supervision methods, and perfecting the construction of discipline inspection cadre teams.

Non-alcoholic fatty liver disease(NAFLD)is a metabolic syndrome caused by a variety of pathogenic factors and characterized by the excessive deposition of fat in liver cells.At present,the pathogenesis of NAFLD is not fully understood,and there is a lack of specific drugs for NAFLD in clinical practice.Therefore,the establishment of an ideal animal model is extremely important for clarifying the pathogenesis of NAFLD and developing specific drugs and treatments.In addition to NAFLD animal models,an increasing number of disease-syndrome combined models related to NAFLD has emerged with the continuous renewal and development of traditional Chinese medicine over the past five years.This article summarizes the NAFLD animal models commonly used within the past five years,as well as their preparation and evaluation method,to provide a reference for future studies in NAFLD animal model preparation and modeling a combination of disease and syndrome.

Objective:To analyze the current status of routine supervision by the discipline inspection departments of public hospitals and the existing problems, and discussion of countermeasures, in order to provide reference for improving the supervision and management of discipline inspection.Methods:In January 2023, 19 full-time discipline inspection cadres from Beijing municipal public hospitals were selected as the subjects of the investigation. A self-made questionnaire was used, and the survey was conducted through the Questionnaire Star platform to understand the current status of routine supervision by discipline inspection departments in various public hospitals, with descriptive analysis of the questionnaire data. From October to December 2023, 12 full-time discipline inspection cadres from 8 Beijing municipal public hospitals were selected as interview subjects. Face-to-face interviews were conducted on how to effectively carry out routine supervision and how to utilize the roles of discipline committee members and branch discipline inspection committee members, with Colaizzi′s seven-step method used to analyze the interview data.Results:41 valid questionnaires were collected. The results showed that the routine supervision matters mainly involved political supervision and supervision of key links in the operation of power, including the implementation of the Central Eight Regulations and their detailed rules (40 people, 97.6%), the selection and appointment of cadres (40 people, 97.6%), the execution of party discipline by party members and leading cadres (39 people, 95.1%), and the implementation of significant decisions and deployments by the state, Beijing municipal and higher-level departments (38 people, 92.7%), etc.; routine supervision was mainly carried out through meeting supervision (41 people, 100.0%), collaborative supervision (41 people, 100.0%), special supervision (40 people, 97.6%), and letter and visit supervision (40 people, 97.6%); the weakness in routine supervision mainly included insufficient supervision of the party committee at the same level (29 people, 70.7%), etc. The lack of information technology means such as " internet" and " big data" (26 people, 63.4%), insufficient professional knowledge training for discipline inspection cadres and lack of professional personnel (26 people, 63.4%), insufficient supervision capabilities of discipline inspection cadres (26 people, 63.4%), limited methods of routine supervision (26 people, 63.4%), and insufficient innovation in supervision methods (26 people, 63.4%) had affected the effectiveness of routine supervision. Analysis of the interview materials yielded five themes: building a supervision system, grasping the key content of routine supervision, optimizing the methods of routine supervision, enriching the paths of supervision, and strengthening the construction of integrity culture and discipline inspection cadres.Conclusions:The routine supervision efficiency of the discipline inspection departments in Beijing municipal public hospitals still needs to be further improved. It is recommended to further improve the relevant work from the aspects of strengthening the construction of the discipline inspection supervision system, enhancing the efficiency of discipline inspection supervision, reinforcing information technology supervision methods, and perfecting the construction of discipline inspection cadre teams.