1.Advances in ncRNA regulation of programmed cell death affecting polycystic ovary syndrome
Pujia REN ; Debang LI ; Terigele DAI ; Xiujuan CHEN ; Chen DU
Chinese Journal of Reproduction and Contraception 2024;44(10):1085-1091
Polycystic ovary syndrome (PCOS) is one of the most common reproductive endocrine disorders in women of reproductive age, and its pathogenesis is not yet fully understood. Many studies have confirmed that programmed cell death (PCD) can affect the occurrence and development of PCOS, and regulating PCD may be the key to prevent and treat PCOS. Recent researches have revealed many non-coding RNA (ncRNA) related to epigenetics, including microRNA, long ncRNA, and circular RNA. Although these ncRNA do not directly serve as carriers of genetic information, they can activate various cellular response mechanisms by regulating the expression of related proteins and genes, such as apoptosis, autophagy, ferroptosis, necroptosis, and pyroptosis, thereby affecting granulosa cell development, disrupting endocrine homeostasis, participating in the pathological process of PCOS, and influencing its prognosis. This paper discusses the pathogenesis of PCOS through the regulation of PCD by ncRNA, aiming to provide new insights for the treatment of PCOS.
2.Advances in ncRNA regulation of programmed cell death affecting polycystic ovary syndrome
Pujia REN ; Debang LI ; Terigele DAI ; Xiujuan CHEN ; Chen DU
Chinese Journal of Reproduction and Contraception 2024;44(10):1085-1091
Polycystic ovary syndrome (PCOS) is one of the most common reproductive endocrine disorders in women of reproductive age, and its pathogenesis is not yet fully understood. Many studies have confirmed that programmed cell death (PCD) can affect the occurrence and development of PCOS, and regulating PCD may be the key to prevent and treat PCOS. Recent researches have revealed many non-coding RNA (ncRNA) related to epigenetics, including microRNA, long ncRNA, and circular RNA. Although these ncRNA do not directly serve as carriers of genetic information, they can activate various cellular response mechanisms by regulating the expression of related proteins and genes, such as apoptosis, autophagy, ferroptosis, necroptosis, and pyroptosis, thereby affecting granulosa cell development, disrupting endocrine homeostasis, participating in the pathological process of PCOS, and influencing its prognosis. This paper discusses the pathogenesis of PCOS through the regulation of PCD by ncRNA, aiming to provide new insights for the treatment of PCOS.
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