1.A Case of Successful Anticoagulant Therapy for Acute Thrombosis Following Mitral Valve Replacement under V-A ECMO
Akitoshi YAMADA ; Ryo TOHMA ; Masanobu SATO ; Yoshihisa MORIMOTO ; Kunio GAN ; Tatsuro ASADA
Japanese Journal of Cardiovascular Surgery 2025;54(3):109-113
A 76-year-old woman, with a history of secundum atrial septal defect (ASD) patch closure 11 years earlier, presented with loss of appetite and dyspnea. She was treated for heart failure due to aortic regurgitation (AR), mitral regurgitation (MR), tricuspid regurgitation (TR), and atrial fibrillation (Af). Upon transfer to our department, she went into shock, leading to the introduction of V-A ECMO and IABP. Emergency surgeries, including aortic valve replacement (AVR), mitral valve replacement (MVR), tricuspid valve annuloplasty (TAP), and left atrial appendage closure, were performed. A second surgery for hemostasis was necessary, and V-A ECMO was removed on the second postoperative day. Transesophageal echocardiography revealed mitral bioprosthetic valve thrombosis. The patient was treated with heparin and warfarin, resulting in improved pressure gradients and removal of IABP by the seventh day. The sternum was closed on the seventeenth day, and she was transferred to the general ward on the thirty-ninth day. This case demonstrates the effective use of anticoagulant therapy for early valve thrombosis after mitral valve replacement under V-A ECMO.
2.Totally Endoscopic 3D Mitral Valve Plasty for a Patient with Loeys-Dietz Syndrome Type 3 and a Narrow Chest
Ryo TOHMA ; Hidekazu NAKAI ; Akitoshi YAMADA ; Yoshihisa MORIMOTO ; Kunio GAN ; Tatsuro ASADA
Japanese Journal of Cardiovascular Surgery 2025;54(6):276-279
Loeys-Dietz syndrome (LDS) is a rare genetic disorder characterized by systemic connective tissue abnormalities. Among its subtypes, LDS type 3 is associated with SMAD3 gene mutations and often presents with vascular and skeletal abnormalities. Narrow chest is a relative contraindication for minimally invasive cardiac surgery (MICS), yet this approach can be advantageous in connective tissue disorders where repeated surgeries may be anticipated. A 63-year-old woman with a previously unreported SMAD3 variant was diagnosed with LDS type 3. She presented with severe mitral regurgitation due to A2-3 prolapse. Her skeletal features included a narrow chest (anteroposterior diameter: 5 cm), scoliosis, and pectus excavatum. Totally endoscopic 3D mitral valve plasty was performed via a right minithoracotomy using a 2-port, 1-window approach. Mitral repair was successfully completed using artificial chordae and ring annuloplasty. Adequate exposure was achieved despite the narrow chest by retracting the pericardium and displacing the aorta using gauze packing. The mitral valve was clearly visualized using the 3D endoscopic camera, allowing safe repair of the A2-3 prolapse with four artificial chordae and a 29-mm Tailor ring. The patient was extubated 3.5 hours postoperatively and had an uneventful recovery except for transient atrial fibrillation. She was discharged on postoperative day 13 in sinus rhythm. Totally endoscopic MICS-MVP is feasible and beneficial even in patients with challenging thoracic anatomy due to connective tissue disease. It enables chest wall preservation and minimizes surgical trauma, which is particularly advantageous for LDS patients with lifelong surgical risk.
3.Successful Surgical Treatment for Pharyngeal Perforation in a Patient with Aortic Valve Infectious Endocarditis
Akitoshi YAMADA ; Kunio GAN ; Takanori TSUJIMOTO ; Jun FUJISUE ; Tatsuro ASADA
Japanese Journal of Cardiovascular Surgery 2019;48(3):189-192
Pharyngeal perforation is a rare but crucial complication of transesophageal echocardiography during cardiac surgery. We herein report the case of a 72-year-old man with infective endocarditis in the aortic valve, who had a poor performance status due to congestive heart failure and brain infarction. The echo probe of the transesophageal echocardiography was detected in the anterior mediastinum after median sternotomy. Pharyngeal repair after aortic valve replacement with bioprosthetic valve, following omental wrapping was performed simultaneously. The operative course was relatively good, and the patient moved to the general ward 32 days after the surgery.
4.A Papillary Fibroelastoma in the Left Ventricle
Yuki Ikeno ; Akitoshi Yamada ; Kunio Gan ; Tatsuro Asada
Japanese Journal of Cardiovascular Surgery 2015;44(3):130-132
A 75-year old woman in whom a left ventricular tumor had been detected by echocardiography 2 years before referral to our hospital, presented with blurry vison for one month. Acute cerebral infarction was diagnosed. We suspected that the infarction was occurred by an embolus from the intraventricular tumor, and resected it through left atrial incision. The resected tumor was 10 mm in size and it resembled a sea anemone. The tumor was pathologically diagnosed as papillary fibroelastoma. The postoperative course was good, with no recurrence for the last 18 months.
5.Two Cases of Graft Replacement of the Infrarenal Abdominal Aorta for Shaggy Aorta Syndrome
Yuki Ikeno ; Akitoshi Yamada ; Kunio Gan ; Tatsuro Asada
Japanese Journal of Cardiovascular Surgery 2015;44(4):212-216
The optimal strategy for shaggy aorta syndrome has not been established, however, several case reports are published with the increase of the aged population. We report two men with shaggy aorta syndrome. The one was 75 years old with acute limb ischemia at the left popliteal artery due to the macroembolism from infrarenal Shaggy Aorta. The other was 76 years old with kidney dialysis, who had suffered from blue toe syndrome due to microembolism from the mobile plaque adhering to the infrarenal aortic wall. We successfully performed graft replacement of the abdominal aorta in order to prevent the recurrence of atheromatous embolization from the Shaggy Aorta. They have been free from any embolic event for the last 1 year. The ultrasonogram was useful for preoperative diagnosis and intraoperative management.
6.Aortic Abdominal Aneurysm Repair in the Patients with Home Oxygen Therapy for Chronic Obstructive Pulmonary Disease
Hiroya Minami ; Tatsuro Asada ; Kunio Gan ; Takuya Misato ; Takashi Munezane
Japanese Journal of Cardiovascular Surgery 2008;37(3):159-163
Between January and December 2006, 3 patients with aortic abdominal aneurysm (AAA) receiving home oxygen therapy (HOT) and 20 patients without HOT were studied. The 3 patients with HOT were all men, the mean age was 72 years (range, 69-74), and they had been treated with HOT for 37.3 months (1-102) due to chronic obstructive pulmonary disease (COPD) with a mean %VC of 96.9% and FEV1.0% of 42.8%. Only the FEV1.0% value in the preoperative data was significantly lower than in patients without HOT. In the 3 patients with HOT, extubation was performed immediately after operation, and minitracheotomy tubes (Mini-trach®) to control sputum were inserted in the operation room. The minitracheotomy tubes were removed 5 or 6 days after operation. Postoperatively, no one with HOT had any major complications, while in those without HOT one patient had ileus and another had prolonged intubation. There were no significant differences between the 2 groups in operative time, blood loss, blood transfusion, or hospital stay. In conclusion, based on detached preoperative close estimation and careful postoperative supervision, patients receiving HOT can undergo AAA operations as safely as those not receiving HOT.
7.Surgical Removal of Left Ventricular Ball-Like Thrombus
Hiroya Minami ; Tatsuro Asada ; Kunio Gan ; Takashi Munezane
Japanese Journal of Cardiovascular Surgery 2007;36(5):248-252
Left ventricular (LV) thrombus is an uncommon primary disease, but following acute myocardial infarction (AMI) it is a common complication associated with a risk of systemic embolism. Especially if the thrombus is ball-shaped, there is a higher risk of systemic embolism. We reviewed 4 cases of thrombectomy including 1 with the acute phase of AMI and another with Takotsubo disease. Between January 2000 and August 2005, 4 consecutive patients underwent thrombectomy for ball-like thrombus in the left ventricle (all men, mean age 53.5 years). We performed thrombectomy through left ventriculotomy. In 3 patients ventriculotomy was repaired with direct closure with double PTFE felt reinforcement, and in the other large acute AMI with the infarction exclusion technique (Komeda-David) because the LV wall was remarkably fragile. All thrombi were ball-like and fresh (mean size 15.8mm). Concomitant coronary artery bypass grafting was performed in 3 cases, the Maze procedure in 2, and mitral annuloplasty (MAP) in 1. All patients survived and have been doing well without any major complications. Surgical thrombectomy is safe and can improve prognosis without systemic embolism. In the acute phase of AMI, the infarction exclusion technique is excellent to prevent bleeding and postoperative remodeling of the left ventricular wall.
8.A Case of Visceral Ischemia Associated with Acute Stanford Type B Aortic Dissection.
Yoshihisa Morimoto ; Nobuhiko Mukouhara ; Tatsuro Asada ; Tetsuya Higami ; Hidefumi Ohbo ; Kunio Gan ; Kazuhiko Iwahashi ; Syuichi Ozawa
Japanese Journal of Cardiovascular Surgery 1996;25(6):415-418
A 36-year-old man was transported to our hospital with severe anterior chest and abdominal pain of sudden onset which was diagnosed as Stanford type B acute aortic dissection with visceral ischemia. Aortogram revealed occlusion of celiac, superior mesenteric and inferior mesenteric arteries with aortic dissection. At first, fenestration of the abdominal aorta above the inferior mesenteric artery was immediately carried out, but the abdominal pain continued. Therefore, bypass grafting for the superior mesenteric artery with saphenous vein was performed the next day. The patient's postoperative course was complicated with acute renal failure and paralytic ileus, which were treated medically and he was discharged in good condition.
9.Aneurysms Arising from a Knitted Dacron Velour Graft Which Caused Acute Arterial Embolization.
Nobuhiko Mukohara ; Kyoichi Ogawa ; Tatsuro Asada ; Tetsuya Higami ; Hidefumi Obo ; Takaki Sugimoto ; Tsuyoshi Kawamura
Japanese Journal of Cardiovascular Surgery 1995;24(1):48-52
A 67-year-old man suffered acute arterial occlusion caused by emboli from aneurysms in a right axillo-bifemoral graft using Cooley double velour knitted Dacron, which was inplanted 10 years and 10 months before the admission. The patient underwent urgent redo surgery; left axillobifemoral bypass with 6mm ringed PTFE graft and right femoropopliteal bypass with in situ saphenous vein were performed successfully. Several clinical experiences by others demonstrated that Cooley double velour knitted Dacron graft, manufactured before June, 1981, might have possible aneurysmogenic factors, therefore cases in which it has been employed should be followed up carefully.
10.Peroneal Artery Bypass Grafting through a Median Approach in Two Cases of Thromboangitis Obliterans.
Kenji Okada ; Nobuhiko Mukohara ; Kyoichi Ogawa ; Tatsuro Asada ; Masami Nishiwaki ; Tetsuya Higami ; Takaki Sugimoto ; Tsuyoshi Kawamura
Japanese Journal of Cardiovascular Surgery 1994;23(2):122-124
In two cases of thromboangitis obliterans (TAO) a popliteal-posterior tibial-peroneal artery sequential bypass was attempted through a median approach. The 1st case underwent the operation successfully with non-reversed saphenous vein graft. However, only popliteal-peroneal bypass was carried out in the 2nd patient because the posterior tibial artery was severely affected. In surgery of TAO patients, careful assessment of preoperative angiographic findings is important to select the site of distal anastomosis. We found that the posterior tibial artery and the peroneal artery are easily accessible through the medial route in the proximal half of the lower leg and that peroneal artery revascularization was effective for limb salvage.


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