Objective To investigate the relationship between internet addiction and SIOSS score,and to examine the mediating role of impulsivity and the moderating role of mental health level.Methods A total of 393 college students were tested with internet addiction scale,Barratt impulsiveness scale-version 11,SIOSS and symptom checklist 90 to establish a moderated mediation model.Results After adjusted for age,internet addiction tendency had a positive predictive effect on SIOSS score(β=0.523,P＜0.01).Impulsivity played a partial mediating role in the relationship between internet addiction and SIOSS score,with a mediating effect value of 0.087(45.72％).The first half of the mediating effect of internet addiction→impulsivity→SIOSS score was moderated by mental health level(β=-0.118,P＜0.001).The predictive effect of internet addiction on impulsivity was stronger in individuals with good mental health level(with the indirect effect value of 0.619 9+0.048 7)compared with the individuals with poor mental health level(with the indirect effect value of 0.439 5+0.048 5).Conclusion Internet addiction can increase SIOSS score by enhancing individual impulsivity,but this effect is more pronounced in individuals with good mental health and then affect SIOSS score.

Objective To describe and analyze the influencing factors of psychological crisis among college students with borderline personality disorder(BPD)traits.Methods Self-compiled general information questionnaire,personality assessment inventory-borderline features scale(PAI-BOR),brief version of the difficulties in emotion regulation scale(DERS-16),short version of the UPPS-P impulsive behavior scale(S-UPPS-P),patient health questionnaire-9(PHQ-9),and psychological crisis screening questionnaire were used to survey 340 college students in Shanghai selected by convenience sampling.Participants were assigned to BPD trait or non-BPD trait groups based on PAI-BOR scores.The risk of psychological crisis and influencing factors of the 2 groups were analyzed.Results A total of 323 valid questionnaires were collected.The average age of the participants was(21.39±2.98)years old,and 164 participants were male and 159 were female.The detection rate of borderline personality disorder traits was 19.20%(62/323).There were significant differences in family relationship,experiences of major changes,difficulties in emotion regulation,impulsivity and depression between the 2 groups(all P＜0.05).The detection rates of mild psychological crisis and severe psychological crisis were significantly higher in the BPD trait group than in the non-BPD trait group(both P＜0.001).Stepwise multinomial logistic regression analysis showed that sensation seeking and difficulties in emotion regulation were risk factors for mild psychological crisis in the BPD trait group(both P＜0.05),and sensation seeking and history of mental disorders in close relatives were risk factors for severe psychological crisis in the BPD trait group(both P＜0.05).Conclusion BPD traits in college students are associated with the risk of psychological crisis.Sensation seeking,difficulties in emotion regulation,and history of mental disorders in close relatives are risk factors of psychological crisis among students with BPD traits.Colleges and universities should put more emphasis on the mental health of students with BPD traits,and formulate targeted preventive measures.

Objective To develop a military cross-cultural symptom scale(MCCSS)and evaluate its reliability and validity.Methods The dimensions and items of the scale were determined through literature analysis,questionnaire surveys,group discussions,expert consultations,and pre-experiments.Cluster sampling was employed to collect data from the participants to examine the psychometric properties of the scale.Results The MCCSS comprised 38 items across 9 factors:depression,anxiety,somatic symptoms,misanthropic tendency,sleep problems,compulsions,psychotic symptoms,stress trauma,and defensiveness.Item analysis revealed that the 37 items(except 1 forced-choice item)exhibited correlations from 0.538 to 0.875 with the total scale score(all P＜0.01),with critical ratios ranging from 5.190 to 28.149,indicating good discriminative power.The Cronbach's α coefficients for the total scale and subscales ranged from 0.825 to 0.972,and the Spearman-Brown split-half reliability coefficients ranged from 0.747 to 0.955.The results of confirmatory factor analysis showed that x2/df=3.419,standardized root mean square residual=0.033,root mean square error of approximation=0.073,normed fit index=0.868,incremental fit index=0.903,Tucker-Lewis index=0.887,comparative fit index=0.902,and the scale's first-order 9-factor model fit well.The loads of each item on the factor to which it belonged ranged from 0.597 to 0.954(all P＜0.01).The correlation coefficients between the scale and the scale for criterion-related validity ranged from 0.392 to 0.773(all P＜0.01),and the correlation coefficients between the scale and the scale for convergent validity ranged from 0.257 to 0.519(all P＜0.01).Conclusion The MCCSS in this study has good reliability and validity and can be used as a mental health testing and screening tool for military personnel.

Objective To investigate the mental health and influencing factors of naval officers and soldiers,and provide data support for formulating effective psychological intervention measures.Methods The 12-item general health questionnaire(GHQ-12)was used to conduct a sample survey among 5 336 naval officers and soldiers from October to November 2021.SPSS 26.0 software,chi-square test and regression analysis were used for descriptive statistics.Results A total of 5 102(95.61%)valid questionnaires were collected.The average GHQ-12 score was 0.55±1.18,and the proportion of high-risk individuals for mental health was 3.06%.Chi-square test showed that there were significant differences in the distribution of mental health status among interviewees with different ages,education levels,marriage status,family economy,family relationship,growing family,history of mental diseases among close relatives,major changes encountered during growth,hobbies and specialties,recent work pressure and recent interpersonal relationship(P≤0.001).Regression analysis showed that age(P=0.006),family relationship(P<0.001),family economy(P=0.010),major changes encountered during growth(P<0.001),recent work stress(P<0.001)and recent interpersonal relationship(P<0.001)were main influencing factors for mental health of naval officers and soldiers.Conclusion The mental health of naval officers and soldiers was generally good,but some individuals still have mental health problems,which are affected by many factors.It is necessary to pay more attention to the mental health problems caused by their age,education,family,growth experience,stress and interpersonal relationship.

Non-suicidal self-injury(NSSI) is defined as deliberate " destruction to body issue without conscious suicidal intent" and which is not culturally and socially sanctioned.The evaluation of NSSI mainly includes explicit measurement and implicit measurement.In recent years, implicit measurement has received wide attention from scholars, among which the implicit association task(IAT), as a tool to measure the relative attitude towards objects in individuals' implicit cognition and to prevent the interference of consciousness, which is an effective method to evaluate NSSI.On the basis of introducing the background of implicit attitude, this paper summarized the research progress of implicit attitude in distinguishing and predicting NSSI from behavioral and neuroimaging perspectives.Firstly, compared with the group without NSSI history, the NSSI group had a more recognized implicit attitude towards NSSI, which was correlated with the frequency and severity of NSSI.Secondly, compared with other known traditional predictors, whether implicit attitude is a better predictor of subsequent behavior of NSSI remains controversial.Finally, there are not many studies on the biological basis of implicit attitude towards NSSI in NSSI populations.Preliminary results suggest that the activation of salience networks and the reduction of gray matter volume in some brain regions (such as the dorsal striatum) may be related to implicit attitude in NSSI populations.To sum up, measuring implicit attitudes towards NSSI is useful for screening and predicting people at risk for NSSI, especially when individuals have false reports or low self-awareness.In addition, this paper also put out some shortcomings for future research and clinical intervention.

Objective To study the effect and mechanism of senegenin on proliferation and differentiation of neural stem cells (NSCs). Methods The primary cultured NSCs were divided into the high-dose, medium-dose, low-dose group and normal control group (NC). The complete medium containing 10, 20 and 40 μmol/L senegenin was added to senegenin low-, middle-, and high- dose groups, and the NC group was routinely cultured. After 4 days of culture, CCK8 assay was used to detect cell viability, and microscopy was performed and the number of neurospheres was counted. Western blot was used to detect the expression of Nestin, TUJ1, GSK-3β, and p-GSK-3β (Ser9), and immunofluorescence staining was used to visualized Nestin and TUJ1. Results Compared with the control group, the number of NSCs neurospheres (32.78 ± 6.30, 40.93 ± 8.34, 45.37 ± 7.96 vs. 26.48 ± 5.19) and the proliferation (127.50% ± 9.31%, 138.13% ± 6.88%, 151.25% ± 9.38% vs. 100.00% ± 5.63%) in the low-, middle- and high-doses of senegenin group significantly increased (P<0.05 or P<0.01).The expression of TUJ1(2.21 ± 0.14,3.10 ± 0.16,3.30 ± 0.15 vs.1.00 ± 0.00)in the low-,middle- and high-doses of senegenin group significantly increased (P<0.05); and the expression of Nestin (0.36 ± 0.04,0.53 ± 0.05,0.46 ± 0.05 vs.1.00 ± 0.00)significantly decreased(P<0.05).The ration of p-GSK-3β(Ser9)/GSK-3β(2.31 ± 0.17,3.41 ± 0.11,3.59 ± 0.16 vs.1.00 ± 0.00)in the low-,middle-and high-doses of senegenin group significantly increased(P<0.01).The cell number of Nestin+(50.29 ± 3.18,45.28 ± 6.23,38.72 ± 5.31 vs. 75.27 ± 6.03) in the low-, middle- and high-doses of senegenin group significantly decreased (P<0.05 or P<0.01), and the cell number of TUJ1+(32.23 ± 4.36,38.23 ± 6.01,46.23 ± 4.36 vs.20.31 ± 5.23)significantly increased (P<0.01). Conclusions The senegenin may promote the proliferation and differentiation of NSCs through the activation of Wnt pathway.

Objective Studies have shown that problem based learning (PBL) can improve the students' ability of autonomous learning.However,it is unclear whether students' autonomous learning ability will affect students' evaluation in PBL teaching.This study took medical psychology course as an example to explore the influence of medical students' autonomous learning ability on PBL teaching effect.Methods 43 8-year program medical students of Grade 2010 and 2011 were enrolled in this study.Scale was used to assess medical students' autonomous learning ability before the start of the PBL teaching.Self made questionnaire was used to survey the students' evaluation in PBL teaching.Linear correlation analysis was used to detect the relationship between medical students' autonomous learning ability and students' evaluation in PBL teaching and their examination results.Results Medical students' autonomous leaming ability is significantly positively correlated to the students' evaluation of PBL teaching (P＜0.05).The correlation coefficient between learning motivation and "PBL enhanced learning interest" or "PBL enhanced information utilization ability" was high (r=0.507 and 0.536,respectively).It showed that students with stronger autonomous learning ability had more positive evaluation of PBL teaching.The students' learning motivation was also positively correlated to the test score (r=0.416,P=0.006).Students with stronger learning motivation had higher test score in the final exam.Conclusion These results indicate that the relationship between the students' autonomous learning ability and PBL teaching is bidirectional.The students with more powerful ability of autonomous learning will be more active in the process of PBL teaching,and the positive experience will promote their autonomous learning ability in turn.

According to the course teaching requirements of psychiatry,a serial teaching cases of case-based learning (CBL) is built based on cases from psychology department to assist in the theory teaching of Psychiatry.During the teaching process,the scenes where patients came to the psychology department were simulated and the information about the cases was provided step by step.For each step,students would be asked to discuss a series of questions regarding the cases in different groups.Along with CBL,students could thoroughly learn the main points of diagnosis and principles of treatment for common psychiatric disorders.The teaching effect showed that students' involvement in CBL courses,the interests in learning,self-study ability,independent thinking ability,capacity for self-expression,ability of creative thinking and comprehensive analysis and problem solving ability.were greatly improved.Most students were interested in CBL and it produced fruitful teaching results.

Objective To investigate the risk factors for intracranial atherosclerosis in patients with ischemic stroke.Methods The demographic data and vascular risk factors in patients with ischemic stroke who performed digital subtraction angiography were analyzed retrospectively.According to the lesion locations,the patients with moderate to severe intracranial arterial stenosis were divided into intracranial internal carotid artery,middle cerebral artery,intracranial vertebral artery,and basilar artery.The démographic data and vascular risk factors among all groups were compared.Results A total of 344 patients with ischemic stroke were recruited,147 (42.7％ ) of them were moderate to severe intracranial arterial stenosis and 197 (57.3％ ) were mild intracranial arterial stenosis.Univariate analysis showed that the proportion of diabetes (34.0％ vs.20.8％,x2 =7.541,P=0.006) or hyperlipidemia (78.9％ vs.66.0％,x2 =6.900,P=0.009) in the moderate to severe intracranial arterial stenosis groups was significantly higher than that in the mild intracranial arterial stenosis group.The levels of total cholesterol (4.656 ±0.955 mmol/L vs.4.401 ±0.882 mmol/L,t =-2.543,P =0.011),low-density lipoprotein cholesterol (3.015 ± 0.817 mmol/L vs.2.741 ± 0.786 mmol/L,t =-3.113,P =0.002),fasting blood glucose (FBG) (6.184 ± 2.127 mmol/L vs.5.568 ±1.772 mmol/L,t =-2.869,P =0.004),and the National Institutes of Health Stroke Scale score (5.48 ± 4.980 vs.4.33 ± 4.094,t =-2.332,P =0.020) were significantly higher.Multivariable logistic regression analysis showed that diabetes (odds ratio [ OR ] 1.907,95％confidence interval [ CI] 1.164-3.124; P =0.010) and low-density lipoprotein cholesterol (OR 1.500,95％ CI 1.133-1.986; P =0.005) were the independent risk factors for moderate to severe intracranial arterial stenosis.Among the patients with different locations of intracranial arteries,there were significant differences in the distribution of the risk factors,such as male (P =0.017),coronary artery disease (P =0.002),and smoking (P =0.026).Conclusion Diabetes and the increased level of low-density lipoprotein cholesterol were the independent risk factors for moderate to severe stenosis of intracranial arteries.The distribution of risk factors for intracranial atherosderosis had location specificity.

Objective To investigate risk factors and prognosis of hemorrhagic transformation(HT)in acute cerebral infarction patients treated by intravenous thrombolysis with recombinant tissue plasminogen activator(rt-PA).Methods All 128 patients with acute cerebral infarction were treated with intravenous rtPA within 6 hours from stroke onset.The clinic records and laboratory datas of pre-and post-treatment were statistically analyzed between HT group and non-HT group to find potential risk factors to HT and contributors of prognosis.Results HT occurred in 29 patients(22.66％),including 16 patients with symptomatic ICH(12.50％)and 2 patients died(6.90％ of HT).Logistic regression analysis showed that history of atrial fibrillation(OR =1.293,95％ CI 1.224-1.589,P =0.001),CT density changes with mass effect or edema(OR =2.452,95％ CI 1.132-3.309,P =0.034),diastolic blood pressure ≥ 100 mm Hg before thrombolytic therapy(1 mm Hg =0.133 kPa,OR =9.265,95％ CI 1.435-59.836,P =0.019),blood glucose ≥ 11.1 mmol/L(OR =3.037,95％ CI 0.252-57.593,P =0.047),NIHSS score ＞ 15 points (OR =8.752,95％ CI 1.035-30.285,P =0.023)and thrombolysis time ＞ 3 h(OR =98.74,95％ CI 5.067-186.120,P =0.002)are independent risk factors for HT; among these factors,baseline blood glucose(OR =3.265,95 ％ CI 0.435-59.863,P =0.045),NIHSS score(OR =10.453,95 ％ CI 5.647-38.185,P =0.003)and thrombolysis time(OR =2.541,95％ CI 1.098-51.086,P =0.017)also are prediction factors of the prognosis of HT.Conclusion Risk factors associated with HT are diastolic blood pressure before thrombolysis,glucose level,degree of neurological deficits,CT early changes,atrial fibrillation and thrombolytic time.Glucose level,neurological deficits and thrombolysis time affects the prognosis of patients.