Isocitrate dehydrogenase(IDH)wild-type glioma is a type of highly invasive brain tumor with poor prognosis and a high recur-rence rate.The recurrence process is driven by multiple complex and interwoven factors.Although the current standard treatment regi-mens can temporarily alleviate patients'symptoms,they still face significant challenges in effectively preventing tumor recurrence.The re-currence mechanism of this tumor is intricate and covers multiple aspects such as genomic instability,maintenance of stem cell characterist-ics and mesenchymal transformation,as well as dynamic changes in the tumor microenvironment.This article aims to comprehensively sum-marize the recurrence mechanism of glioblastoma and deeply explore potential countermeasures targeting these mechanisms,hoping to open up new perspectives and approaches for the treatment of recurrent tumors.

Isocitrate dehydrogenase(IDH)wild-type glioma is a type of highly invasive brain tumor with poor prognosis and a high recur-rence rate.The recurrence process is driven by multiple complex and interwoven factors.Although the current standard treatment regi-mens can temporarily alleviate patients'symptoms,they still face significant challenges in effectively preventing tumor recurrence.The re-currence mechanism of this tumor is intricate and covers multiple aspects such as genomic instability,maintenance of stem cell characterist-ics and mesenchymal transformation,as well as dynamic changes in the tumor microenvironment.This article aims to comprehensively sum-marize the recurrence mechanism of glioblastoma and deeply explore potential countermeasures targeting these mechanisms,hoping to open up new perspectives and approaches for the treatment of recurrent tumors.

Isocitrate dehydrogenase(IDH)mutation occurs frequently in glioma,cholangiocarcinoma,acute myeloid leukemia,chondro sar-coma and other tumors,and it's a potential target for cancer treatment.The novel cancer metabolite 2-hydroxyglutaric acid(2-HG)pro-duced after mutation has become an important marker for cancer treatment and prognosis evaluation.IDH mutation accurately down-regu-lates various biological processes such as glucose metabolism,lipid metabolism and amino acid metabolism in tumors.In addition,IDH mutation also affects the balance of immune microenvironment and epigenetic regulation,and its mechanism of action in the occurrence and development of cancer needs to be further explored and studied.This article reviews the mechanism of action and potential therapeut-ic strategies of IDH mutation in the development of tumors,aiming to provide novel therapeutic options for patients with IDH mutation.

Isocitrate dehydrogenase(IDH)mutation occurs frequently in glioma,cholangiocarcinoma,acute myeloid leukemia,chondro sar-coma and other tumors,and it's a potential target for cancer treatment.The novel cancer metabolite 2-hydroxyglutaric acid(2-HG)pro-duced after mutation has become an important marker for cancer treatment and prognosis evaluation.IDH mutation accurately down-regu-lates various biological processes such as glucose metabolism,lipid metabolism and amino acid metabolism in tumors.In addition,IDH mutation also affects the balance of immune microenvironment and epigenetic regulation,and its mechanism of action in the occurrence and development of cancer needs to be further explored and studied.This article reviews the mechanism of action and potential therapeut-ic strategies of IDH mutation in the development of tumors,aiming to provide novel therapeutic options for patients with IDH mutation.