Background: According to the results of the research conducted in Mongolia in 2011 within the framework of the national program "Oral Health", 86.2% of young children had tooth decay, and the intensity of tooth decay was 6.2, which is a high level. In recent years, not only in our country, but also in the world, due to the increase in the prevalence of tooth decay in young children, the disease of other organ systems caused by tooth decay has also increased, which is the basis of our research. Purpose: To study the intensity of dental caries among secondary school students and comparing them with some indicators Objective:
1. To estimate the intensity of dental caries among secondary school students
2. To study the intensity of dental caries among secondary school students by comparing some parameters. Methodology: A total of 1298 students aged 6-18 years of Bayanzurkh Complex School of the capital were included in the study. Determine the body mass index ,The Lith the lip method was used to calculate the intensity of dental caries and it was assessed by the World Health Result: 675(52%) of the respondents were male and 623(48%) were female, 7.6% were underweight, 68% were normal weight, 14.7% were overweight, and 9.7% were obese.
When examining the state of dental disease of the participants, 9% were healthy, 91% had dental disease, the intensity of caries was 4.9 CSI, and the need for rehabilitation was 319. Out of this, in children with permanent teeth, the intensity of caries in great molars and in children with mixed teeth is higher in second molars. Conclusion The intensity of dental caries is 4.9 cla/sh or more, and the prevalence is high, and there are 319 children who need to be treated immediately.
The intensity of dental caries was medium for 6-13 year olds and low for 14-19 year olds, and the caries intensity of normal weight children was 3.3 or medium.

Background: Vancomycin was first approved by the US Food and Drug Administration (FDA) in 1958. Vancomycin has an active effect on gram-positive microorganisms, such as methicillin- resistant Staphylococcus aureus (MRSA), coagulase-negative staphylococcus, Streptococcus (Enterococcus faecalis), and Clostridia (Clostridium difficile). It is used in the treatment of severe infections such as endocarditis, osteomyelitis, pneumonia, blood and soft tissue infections, other staphylococcal infections, and S. epidermidis with a β-lactam ring structure that is ineffective or allergic to antibiotics and resistant to many drugs. Materials and Methods: To carry out the study, we obtained permission to conduct the study from the National Institute of Health and Welfare, and randomly sampled a total of 274 inpatients who used vancomycin in the hospital in 2023 in order to be representative in terms of age and gender (n=120). Results The one dose of vancomycin was 0.9 mg, the daily dose was 2.4 mg, the total dose was 20.5 mg, and the total daily average was 11.3 days. The daily dose and total dose of vancomycin were inversely proportional to age (r=-0.008), and the total dose is very weakly correlated with BMI and gender (r=0.052). Cefazolin used in combination with vancomycin had statistically significant differences in monocyte counts (p=0.003), cefotaxime in lymphocyte counts (p=0.027), and ceftriaxone in total white blood cell counts (p=0.048). Conclusion: Vancomycin daily dose is inversely related to age, total dose is inversely related to age, and total dose is very weakly correlated with BMI and gender. There is a statistically significant difference in the use of vancomycin with cephalosporin antibiotics

Background: Vancomycin is a glycopeptide antibiotic widely used to treat infections caused by gram-positive bacteria, especially methicillin-resistant Staphylococcus aureus (MRSA). Despite its effectiveness, vancomycin is known to be nephrotoxic, particularly when administered in high doses, for prolonged durations, or in combination with other nephrotoxic agents. This study aims to investigate the incidence and influencing factors of vancomycin associated renal impairment among hospitalized patients in Mongolia. Methods: A retrospective document review was conducted among 120 hospitalized patients who received vancomycin at the First State Central Hospital in 2023. Data on vancomycin dosage, treatment duration, clinical diagnoses, and biochemical parameters were analyzed. Renal function was assessed using the Cockcroft-Gault equation and categorized into five stages. Statistical analysis was performed using chi-square tests and logistic regression with a significance level set at p<0.05. Results: The mean age was 52.3 years, and the average BMI was 26.7. Among participants, 41.5% showed varying degrees of renal impairment. Vancomycin daily dose was significantly associated with the stage of renal impairment (p=0.040), while total dose and treatment duration were not. Co-administration with cefotaxime and metronidazole showed statistically significant changes in creatinine and urea levels, suggesting potential additive nephrotoxicity. Conclusion The findings indicate a substantial rate of renal function decline among vancomycin-treated patients. Higher daily doses and concurrent use of nephrotoxic antibiotics may increase the risk. Regular renal monitoring and dose adjustments are essential to minimize adverse renal outcomes.

: A study by Marsot and other investigators (2012) determined that the dose of vancomycin in adults is directly dependent on parameters such as creatinine clearance and body weight, as well as the need for dose correction. We used the MDRD equation to determine renal dysfunction in 113 inpatients and found grade I in 50.5%, grade II in 14.4%, grade III in 10.8%, grade IV in 6.3%, and grade V in 18%. There is a statistically significant difference (p=0.045) in renal dysfunction depending on the diagnosis. The average daily dose of vancomycin was 2.5 g, the total daily dose was 8.5 g, the total dose was 20.5 g. The daily dose and total dose of vancomycin were inversely proportional to age (g = -0.256), the daily dose was directly related to excess weight body (g=0.226), and days of vancomycin use are statistically significant (p=0.001) depending on the diagnosis. Conclusion Comprehensive programs are required to improve the vancomycin use in the hospitals. Vancomycin use should be monitored due to its large-scale empiric use. The rate of improper use of vancomycin in the infection and intensive care unit services may be high, and pharmacists must take appropriate action to optimize the use of the drug.

Oxytropis microphylla is a herbal medicines plant that has been widely used in Mongolia and China. Our aim of this study is to identify morphological and anatomical structure and to determine some pharmacological actions. LD50 of the 1:5 infusion of Oxytropis microphylla was 304.17 mg/kg. Anti-inflammation action has been compared with untreated group, 304.26 mg/ kg dosage of Oxytropis microphylla preparation has been decreased (by 24.5%) induced by histamine in the back paw of experimental white mice during the observation time of 120-150 minutes. There is no significant of diuretic action of Oxytropis microphylla.