Purpose: This study was intended to examine the effects of fatigue and rewards on health-promoting behaviors among clinical nurses. Methods: Data were collected from 157 nurses with more than nine months of clinical experience between June 13 and July 9, 2024. A structured self-report questionnaire was used to assess fatigue, rewards, and health-promoting behaviors. The data were analyzed using descriptive statistics, independent t-tests, one-way ANOVA, Duncan’s tests, Pearson's correlation coefficient, and multiple regression analysis. Results: Fatigue was negatively correlated with health-promoting behaviors (r=-.43, p<.001), while rewards were positively correlated (r=.39, p<.001). Multiple regression analysis revealed that both fatigue (β=-.36, p<.001) and rewards (β=.26, p=.002) were significant predictors of health-promoting behaviors. Conclusion The findings indicate that fatigue and rewards are key factors influencing health-promoting behaviors among clinical nurses. Interventions aimed at reducing fatigue and enhancing reward systems are essential for fostering health-promoting behaviors among clinical nurses.