Limb salvage surgery using a tumor prosthesis for the treatment of malignant bone tumors in the proximal femur is an effective method for preserving hip joint function. On the other hand, maintaining hip joint stability can be challenging because of the extensive resection of the bone and surrounding soft tissue. This paper reports an unusual case of hip dislocation in a patient with a proximal femoral osteosarcoma who underwent limb salvage surgery. Over six years, the tumor prosthesis gradually migrated posterosuperiorly above the iliac crest, resulting in 14 cm of lower limb shortening. The acetabular reconstruction was performed using an allograft, and the middle segment of the tumor prosthesis was removed to allow for hip reduction. Concurrent reconstruction of the hip abductor muscles was also carried out. No recurrence of the dislocation was observed during follow-up, and the patient could walk independently with the aid of an orthopedic brace, despite an 8 cm leg length discrepancy.

Penetrating cardiac foreign body injuries are infrequent but potentially life-threatening occurrences. This paper presents a brief case report of a patient who presented to the emergency department (ED) with self-inflicted injuries. A 14-cm cylindrical hollow stick was embedded into his right ventricle. Remarkably, the patient remained hemodynamically stable and showed no significant symptoms. The clinical manifestations of penetrating cardiac foreign body injuries may vary from a stable hemodynamic condition to a rapid cardiovascular collapse. A penetrating cardiac foreign body is a rare traumatic injury encountered in the ED. Nevertheless, an awareness of this case is essential because it provides insights into the diversity of presentations of cardiac foreign body injuries. Although these injuries often manifest with severe symptoms such as cardiac tamponade, massive hemothorax, or even cardiac arrest, this case shows that patients may remain hemodynamically stable and asymptomatic, making a diagnosis challenging.

Purpose: Radical cystectomy (RC) is associated with substantial postoperative morbidity, and unplanned readmission remains common despite advances in perioperative management. However, the association between postoperative readmission due to complications and oncologic outcomes after RC for bladder cancer has not been clearly defined. We evaluated the impact of postoperative readmission on overall survival (OS) and cancer-specific survival (CSS) after RC for bladder cancer. Materials and Methods: We retrospectively analyzed 3,972 patients who underwent RC for bladder cancer in a multicenter cohort. Postoperative readmission was defined as unplanned hospitalization within 90 days postsurgery due to surgery-related complications. Survival outcomes were assessed using the Kaplan-Meier method and compared using the log-rank test. Univariable and multivariable Cox proportional hazards regression analyses were performed to identify independent predictors of OS and CSS. Results: Among the study population, 916 patients (23.1%) experienced postoperative readmission. Baseline and perioperative characteristics were generally comparable between patients with and without readmission. Kaplan-Meier analyses demonstrated significantly worse OS and CSS among patients who experienced postoperative readmission (both log-rank p<0.001). In multivariable analyses adjusting for clinicopathological factors, postoperative readmission remained independently associated with worse OS (hazard ratio [HR], 1.654; 95% confidence interval [CI], 1.464–1.868; p<0.001) and CSS (HR, 1.761; 95% CI, 1.509–2.055; p<0.001). Conclusion Postoperative readmission within 90 days after RC was independently associated with inferior long-term oncologic outcomes. These findings suggest the importance of strategies aimed at preventing postoperative complications and subsequent readmission.

Objective: To evaluate the effects of reduced kVp and reduced iodinated contrast volume on radiation dose and image quality in canine abdominal CT. Methods: A phantom study (0%–10% iodine dilutions) at 120, 100, and 80 kVp quantified the relationship between iodine concentration and CT attenuation. Eight healthy Beagle dogs underwent multiphase abdominal CT at 120, 100, and 80 kVp (1-week intervals) with weightbased contrast volumes adjusted using phantom-derived slope ratios. Radiation output (CTDIvol , dose-length product) and quantitative image quality (attenuation, background noise, signal-to-noise ratio [SNR], contrast-to-noise ratio [CNR]) were assessed, along with blinded qualitative scoring by 2 readers. Results: Compared with 120 kVp, CTDIvol decreased by 41% at 100 kVp and 74% at 80 kVp, with similar proportional decreases in dose-length product. Lower kVp increased iodinerelated attenuation, permitting iodine-dose reductions (17% at 100 kVp; 34% at 80 kVp).Quantitative noise increased and SNR decreased at 80 kVp, particularly in delayed-phase images; qualitative noise scores were significantly worse at 80 kVp, whereas overall qualitative image quality did not differ across protocols. Conclusions and Relevance: In dogs, a 100 kVp protocol reduced radiation output and iodine dose while maintaining diagnostic image quality, supporting 100 kVp as a practical optimization strategy for clinical abdominal CT.

Objective: To classify life stages for companion dogs and cats by identifying clusters in age-specific disease proportions derived from medical records, providing a data-driven foundation for health examination programs. Methods: We collected 505,667 medical records from 82 veterinary facilities in South Korea between 2020 and 2023. Diagnoses were standardized using GPT-4o and S-BioBERT. Following preprocessing, data from 27 facilities yielded 222,706 canine and 39,910 feline records for the final analysis. Principal component analysis and K-means clustering (K = 4) were applied to age-specific disease proportions to identify life stages.The 10 most highest-proportion diagnoses diseases were determined for each cluster. Results: Canine life stages were classified as ≤ 1 year, 2–5 years, 6–10 years, and 11–15+ years.Feline life stages were 1–2 years, 3–8 years, 9–12 years, and 13–15+ years. In dogs, developmental diseases were common in the youngest age group, while chronic diseases were more prevalent in older groups. In cats, oral and urinary diseases were high-ranking, conjunctivitis was most common in the early stage, and chronic diseases increased with age. Conclusions and Relevance: Age-specific diagnosis patterns support four practical life stages for dogs and cats in South Korea. These boundaries can inform evidence-based preventive examination schedules, animal health policy, and pet insurance product design.

Background: This study assessed 10-year changes in the proportion and epidemiology of work-related burns among inpatients at a single institution; as an institutional proportion, results reflect within-center surveillance. Methods: Burn inpatients admitted in 2016–2025 (n=5,074), including work-related burns (n=535), were retrospectively reviewed. Annual proportions were calculated. Because proportions dropped during COVID-19 (2020–2022), these years were excluded from the primary trend analysis. Period differences were tested with two-proportion tests and an overall 2×3 chi-square test; trends excluding 2020–2022 were evaluated with linear regression. Results: Work-related burns accounted for 10.5% (535/5,074). The proportion decreased in 2020–2022 versus 2016–2019 (7.7% vs. 10.9%; P=0.002) and increased in 2023–2025 versus 2020–2022 (13.1% vs. 7.7%; P<0.001); overall period differences were significant (chi-square P<0.001). Excluding 2020–2022, the proportion increased by +0.34 percentage points/year (95% confidence interval, 0.05–0.63; P=0.029). Scalds (53.6%) and electrical burns (18.5%) predominated. Mean burn total body surface area (TBSA) was 5.9%±9.2%, with 83.7% <10% TBSA; 78.9% were second-degree burns. Surgery was performed in 292 (54.6%), most commonly split-thickness skin grafting (STSG; n=150) or STSG with acellular dermal matrix (n=92). The highest incidence occurred in summer (33.3%). Conclusion After excluding 2020–2022, the institutional proportion of work-related burns increased over time despite declining total burn admissions. This reflects a relative shift in case-mix, not population-level incidence; explanations such as changing exposures or improved reporting/compensation are hypothesis-generating.

Background: Cisplatin-based chemotherapy is a mainstay treatment for head and neck squamous cell carcinoma (HNSC); however, resistance to cisplatin contributes substantially to poor clinical outcomes. Identifying biomarkers associated with cisplatin response may improve prognostic assessment and treatment selection. Methods: We retrospectively analyzed The Cancer Genome Atlas (TCGA)-HNSC dataset to evaluate the association between microtubule associated scaffold protein 1 (MTUS1) expression and clinical outcomes, with particular emphasis on patients who were cisplatin-treated. Survival analysis was performed using the Kaplan-Meier curves, and differential expression analysis was conducted separately by comparing patients in disease-specific survival (DSS)-living and DSS-deceased groups. MTUS1 messenger RNA and protein levels were examined in cisplatin-sensitive oral cancer cell lines and their paired cisplatin-resistant counterparts using quantitative reverse transcription polymerase chain reaction and western blotting. Functional relevance was assessed by small interfering RNA-mediated MTUS1 knockdown in primary oral squamous cell carcinoma organoids. Results: MTUS1 protein expression was significantly lower in HNSC tumors than in non-tumor tissues. In the overall TCGA-HNSC cohort, MTUS1 expression was not significantly associated with survival. However, in patients who were cisplatin-treated, higher MTUS1 expression was significantly associated with more favorable DSS. MTUS1 expression was consistently lower in cisplatin-resistant oral cancer cell lines than in their paired cisplatin-sensitive counterparts. Functional experiments further suggested that reduced MTUS1 expression is associated with decreased cisplatin sensitivity and a resistant phenotype. Conclusion MTUS1 expression may be associated with clinical outcomes in patients with cisplatin-treated HNSC and is related to cisplatin responsiveness. These findings suggest a role for MTUS1 as a candidate treatment-relevant biomarker and highlight the value of integrating public omics data with experimental validation.

Background: Textile dyeing workers are at an increased risk of developing occupational respiratory diseases owing to frequent exposure to harmful chemicals, irritants, and high humidity in the workplace. Pulmonary rehabilitation is essential but associated with access and adherence challenges. This study aimed to evaluate the feasibility, effectiveness, accessibility, and safety of an app-based pulmonary telerehabilitation program for this population. Methods: Forty-five textile dyeing workers with respiratory symptoms underwent a 4-week pulmonary telerehabilitation program consisting of daily gamified respiratory muscle training using a Bluetooth-enabled device and video-guided flexibility exercises. The program was delivered through a mobile application and adherence was monitored using an online platform. Pulmonary function tests, 6-minute walk test, hand grip strength, and St. George’s Respiratory Questionnaire (SGRQ) scores were assessed at baseline (T0) and post-intervention (T1). The adherence, adverse events, and system usability were evaluated. Results: Improvements were observed in forced expiratory volume in 1 second (FEV1), FEV1/forced vital capacity, maximal inspiratory pressure, and maximal expiratory pressure at T1 compared to T0. The SGRQ activity scores improved after the intervention. The mean adherence rate was 95.69%; three participants had adherence rates <80% for ≥1 week each. The mean System Usability Scale score was high. Conclusion The program resulted in significant improvements in pulmonary function and quality of life with high adherence rates and good usability. This may be a promising approach for managing occupational respiratory diseases among textile dyeing workers. Further studies with larger sample sizes and longer follow-up periods are warranted to validate these results and assess the long-term outcomes.

Extracellular vesicles (EVs) are nanosized membranous particles released by nearly all cell types, playing a crucial role in mediating cell-to-cell communication. The molecular profile of EVs often reflects that of their originating cells, rendering them valuable for therapeutic and diagnostic purposes. The kidney comprises various cell types, and urinary EVs are predominantly produced from tubular, glomerular, and urinary bladder cells. Within the nephron, EVs produced from the upper segments, such as glomerular tufts and proximal tubules, can be taken up by their downstream counterparts, thereby altering the physiology of recipient cells. Recent studies have demonstrated that this proximal-distal intra-nephron crosstalk via EVs is crucial for normal kidney physiology. Additionally, EVs from interstitial cells (e.g., fibroblasts and macrophages) have been demonstrated to mediate the exacerbation of kidney damage. This review provides up-to-date findings on the function of renal EVs during the progression of renal diseases. Furthermore, we discussed future directions to use the clinical potential of renal EVs as an early biomarker for renal disorders.