Total hip arthroplasty (THA) can be a good treatment option for avascular necrosis (AVN) of the femoral head. However, because dislocation can frequently occur after surgery, THA is a concern in patients with a neuromuscular disease, such as cerebral palsy or poliomyelitis. In patients with poliomyelitis, only one case of AVN of the femoral head in the affected limb has been reported in the English literature. Here, the authors report on a case of AVN of the femoral head in a patient with poliomyelitis, who was treated with a large diameter femoral head metal-on-metal THA using a modified minimally invasive-2-incision technique.
Arthroplasty ; Cerebral Palsy ; Dislocations ; Extremities ; Head ; Hip ; Humans ; Necrosis ; Neuromuscular Diseases ; Poliomyelitis ; Tacrine

For several centuries, orthopaedic surgeons have been given the task of managing the pain, limp, and gait disturbance that develop in association with various trauma and diseases of the hip joint. Progress has been made in development of surgical methods for the hip joint, and a recent concept was determined by introduction of the 'Clean Air Operating Enclosure' system and 'low frictional arthroplasty' in total hip arthroplasty (THA) by John Charnley, in 1960. THA has been performed as an exclusive method for hip joint reconstruction. We report on understanding of the current status from the past, present, and future trends with an introduction of the prior method of THA and a discussion of the history.
Arthroplasty ; Friction ; Gait ; Hip ; Hip Joint ; Tacrine

Vascular complications after total hip arthroplasty (THA) are rare and mainly occur after revision surgery, and of these complications, large artery thrombosis is relatively uncommon. Nevertheless, this complication has potentially devastating effects on the affected lower extremity. The authors report a case of acute thrombosis in an iliac artery stent and femoro-popliteal bypass graft after primary cementless THA, and include relevant literature review.
Arteries ; Arthroplasty ; Hip ; Iliac Artery ; Lower Extremity ; Stents ; Tacrine ; Thrombosis ; Transplants

PURPOSE: The purpose of this study is to evaluate the early results and occurrence of complications of cementless total hip arthroplasty (THA) using an alumina-on-alumina articulation with a minimum follow up period of three years. MATERIALS AND METHODS: We prospectively followed 108 patients (121 hips) who underwent cementless THA using an alumina-on-alumina articulation. The mean age of the patients was 50.7 years (range, 20-80 years) and mean the follow up period was 48 months (range, 36-60 months). Preoperative diagnoses included osteonecrosis of the femoral head in 90 hips; secondary osteoarthritis due to hip dysplasia in 24 hips; secondary osteoarthritis after acetabular fracture in four hips; acute femoral neck fracture in three hips. Clinical evaluation was performed using Harris hip score (HHS) and radiographic evaluation was performed in terms of the fixation of components and the prevalence of osteolysis. In addition, we observed complications, including the occurrence of sound or fracture of the alumina head or liner. RESULTS: Mean HHS improved from 62.4 points to 94 points at final follow-up. Thigh discomfort was found in six hips and mild inguinal discomfort was found in eight hips. Both had disappeared within one year after operation. A clicking sound was detected in two patients. One hip had become dislocated and an alumina liner fracture had occurred in one hip. Loosening of component or osteolysis was not observed in any hip. The radiographic wear was not measurable. CONCLUSION: Early results of cementless THA using an alumina-on-alumina articulation were favorable, with osseointegration of the components and absence of periprosthetic osteolysis. However, longer-term follow up for a hip clicking sound and fracture of an alumina fracture are necessary.
Aluminum Oxide ; Arthroplasty ; Femoral Neck Fractures ; Follow-Up Studies ; Head ; Hip ; Humans ; Osseointegration ; Osteoarthritis ; Osteolysis ; Osteonecrosis ; Prevalence ; Prospective Studies ; Tacrine ; Thigh ; Ursidae

Fractures of the femoral neck in elderly patients can be treated by internal fixation, hemiarthroplasty, or total hip arthroplasty (THA), and the treatment modality used should be determined on the basis of considerations of the degree of fracture displacement, age, functional demands, and the risk factors for surgery and anesthesia. We studied 85 active elderly patients who underwent minimally invasive two-incision THA or conventional bipolar hemiarthroplasty (BHA) within 2 weeks of injury for the treatment of acute displaced femoral neck fractures. Patients were followed up for a minimum of 24 months. The average operation times were 70 minutes in the THA group and 46 minutes in the BHA group (p=0.002), and average blood losses during the perioperative period were 921 cc and 892 cc, respectively (p=0.562). In the THA group, the average postoperative Harris hip score was 88.3 and the average Western Ontario and McMaster University score was 28.8, whereas in the BHA group the corresponding scores were 80.4 (p=0.006) and 32.5 (p=0.012), respectively. There were 2 cases of hip dislocation in the THA group, and 2 cases in the BHA group underwent conversion to THA. Our short-term follow-up results were better for minimally invasive two-incision THA than for conventional BHA for the treatment of acute displaced femoral neck fractures in active elderly patients.
Aged ; Anesthesia ; Arthroplasty ; Butylated Hydroxyanisole ; Displacement (Psychology) ; Femoral Neck Fractures ; Femur Neck ; Follow-Up Studies ; Hemiarthroplasty ; Hip ; Hip Dislocation ; Humans ; Ontario ; Perioperative Period ; Risk Factors ; Tacrine

A series of tacrine-methoxybenzene hybrids (5a-5i) were designed, synthesized and evaluated as inhibitors of cholinesterases (ChEs). All the compounds had better ChEs inhibitory activities than tacrine with IC50 values at the nanomolar range. Compound 5h exhibited the strongest inhibition on acetylcholinesterase (AChE) with an IC50 value of 6.74 nmol x L(-1) and compound 5f showed the most potent inhibition on butyrylcholinesterase with IC50 value of 3.83 nmol x L(-1). Kinetic and molecular modeling studies showed that these hybrids targeted both the catalytic active site and the peripheral anionic site of AChE.
Acetylcholinesterase ; metabolism ; Anisoles ; chemical synthesis ; chemistry ; pharmacology ; Binding Sites ; Butyrylcholinesterase ; metabolism ; Catalytic Domain ; Cholinesterase Inhibitors ; chemical synthesis ; chemistry ; pharmacology ; Drug Design ; Inhibitory Concentration 50 ; Tacrine ; chemical synthesis ; chemistry ; pharmacology

Total hip arthroplasty (THA) is rarely performed in below-knee amputee patients. To the best of the authors' knowledge, periprosthetic femoral fracture in such patients has not been previously reported. Such devastating complication can occur even with minor trauma. To prevent occurrence of such events, there may be several important factors to be considered in performance of THA surgery in below-knee amputee patients and during the course of rehabilitation. In this report, we describe a case involving a below-knee amputee patient who experienced multiple periprosthetic femoral fractures after THA.
Amputees ; Arthroplasty ; Femoral Fractures ; Hip ; Humans ; Knee ; Tacrine

Raphanus sativus (Cruciferaceae), commonly known as radish is widely available throughout the world. From antiquity it has been used in folk medicine as a natural drug against many toxicants. The present study was designed to evaluate the hepatoprotective activity of radish (Raphanus sativus) enzyme extract (REE) in vitro and in vivo test. The IC50 values of REE in human liver derived HepG2 cells was over 5,000 microg/ml in tested maximum concentration. The effect of REE to protect tacrine-induced cytotoxicity in HepG2 cells was evaluated by MTT assay. REE showed their hepatoprotective activities on tacrine-induced cytotoxicity and the EC50 value was 1,250 microg/ml. Silymarin, an antihepatotoxic agent used as a positive control exhibited 59.7% hepatoprotective activitiy at 100 microg/ml. Moreover, we tested the effect of REE on carbon tetrachloride (CCl4)-induced liver toxicity in rats. REE at dose of 50 and 100 mg/kg and silymarin at dose of 50 mg/kg were orally administered to CCl4-treated rats. The results showed that REE and silymarin significantly reduced the elevated levels of serum enzyme markers induced by CCl4. The biochemical data were supported by evaluation with liver histopathology. These findings suggest that REE, can significantly diminish hepatic damage by toxic agent such as tacrine or CCl4.
Animals ; Carbon Tetrachloride ; Hep G2 Cells ; Humans ; Inhibitory Concentration 50 ; Liver ; Medicine, Traditional ; Raphanus ; Rats ; Silymarin ; Tacrine

Ceramic-on-polyethylene components have better wear characteristics than metal-on-polyethylene components in total hip arthroplasty (THA), and thus, extensive wear resulting in penetration of the femoral head through the acetabular cup is rare after ceramic-on-polyethylene THA. However, several reports have been issued regarding catastrophic polyethylene failure in ceramic-on-polyethylene systems. Here, the authors report the first case of bilateral complete polyethylene wear failure with acetabular cup perforation after ceramic-on-polyethylene THA.
Arthroplasty ; Ceramics ; Head ; Hip ; Polyethylene ; Tacrine

Ceramic-on-polyethylene components have better wear characteristics than metal-on-polyethylene components in total hip arthroplasty (THA), and thus, extensive wear resulting in penetration of the femoral head through the acetabular cup is rare after ceramic-on-polyethylene THA. However, several reports have been issued regarding catastrophic polyethylene failure in ceramic-on-polyethylene systems. Here, the authors report the first case of bilateral complete polyethylene wear failure with acetabular cup perforation after ceramic-on-polyethylene THA.
Arthroplasty ; Ceramics ; Head ; Hip ; Polyethylene ; Tacrine