BACKGROUND: Incorrect administration of an anesthetic during local anesthesia is one of the most important causes of pain symptoms in patients scheduled for dental procedures. The current study assessed the severity of damage to periodontal tissue following different rates of anesthetic administration. METHODS: The research was conducted on 50 outbred male rats with a body mass of 180–240 g. The anesthetic used was 1% articaine. RESULTS: The results showed that administration of the anesthetic at a rapid pace caused structural damage to the periodontal tissue. Further, signs of impaired microcirculation were noted at all rates of administration. Biochemical studies demonstrated changes in the level of glucose and enzymes with the rapid introduction of the anesthetic, indicating severe systemic stress response of the body. CONCLUSIONS: Injection of local anesthetic at any rate of introduction induces vascular congestion in the microcirculatory bloodstream and exudative reactions. Rapid introduction of an anesthetic causes progression of structural changes in the gingival tissue.
Anesthesia, Local ; Animals ; Carticaine ; Dentistry ; Estrogens, Conjugated (USP) ; Glucose ; Humans ; Male ; Microcirculation ; Mouth Mucosa ; Rats