To systematically synthesize evidence on multiple KRAS G12C inhibitors(KRAS G12C inhibitors, KRAS G12Ci) as monotherapy within a unified population and recommended-dose framework, establish a comparable benchmark range of efficacy and safety for previously treated patients with advanced or metastatic KRAS G12C-mutant non-small cell lung cancer(NSCLC), and explore potential effect modifiers.

Objective:To observe the effect of combining robot-assisted gait training (RAGT) with task-oriented training (TOT) on the walking ability of children with dyskinetic cerebral palsy (DCP).Methods:Sixty DCP children were randomly divided into a conventional intervention group, an RAGT group, and a combined intervention group, each of 20. All of the children received conventional rehabilitation therapy, while the RAGT and combined intervention groups were additionally provided with RAGT, and RAGT combined with TOT, respectively. Before the experiment and after 12 and 24 weeks of treatment, the subjects′ walking ability was evaluated using the 10-metre walk test (10MWT), and the D energy zone (standing position) and the E energy zone (walking, running and jumping) of the Gross Motor Function Measurement-88 (GMFM-88) instrument.Results:After 12 and 24 weeks of treatment, the average 10MWT speed and D and E energy zone scores of all three groups had improved significantly. After 24 weeks the combined group′s averages on all three measures were significantly better than those of the other two groups.Conclusion:RAGT combined with TOT and conventional rehabilitation training significantly improves the walking ability of DCP children.

Objective To investigate the life experience of aged residents living in private rest homes in Shijiazhuang,so as to provide reference for improving their quality of life (QOL).Methods Semi-structured interview was used to investigate 12 residents living in three private rest homes,and the data was analyzed by phenomenological analysis.Results The life experience of aged residents living in private rest homes was summarized with four related topics:high-quality experience,life adaptation,conflict and expectation. Conclusions The life experience of aged residents living in private rest homes in Shijiazhuang is mixed with joy and concern,and it is closely related with the physical condition,operation management mode and service level of retirement organizations. The QOL of aged residents living in private rest homes needs the joint efforts of government,organizations,aged residents′ relatives and friends. They should positively resolve the conflict, promote adaption and improve happiness,so as to improve the life experience of aged residents living in private rest homes.

Objective To evaluate systematically the effects of three motortherapies, namely, yoga, Pilates and core stabilization training, on chronic low back pain (CLBP) with meta-analysis, and to offer a reference for the prevention and control of CLBP. Methods Data of the randomized controlled trails (RCT) concerning the effects of the three motortherapies on CLBP that were published by 31st January, 2017 were collected from PubMed, OVID, Cochrane Library, Web of Science, CNKI, CBM, VIP and WanFang databases by literature tracing and manual retrieval, and the meta-analysis was conducted with RevMan 5.3. Results Totally 19 RCTs and 1 395 patients were included in the study. The meta-analysis results showed: yoga helped to alleviate the pain level of CLBP patients [WMD=-1.68,95%CI (-2.04--1.31), P< 0.01], and improve the patients' functional disorder [WMD=-2.01,95%CI (-2.22--1.79), P< 0.01];core stabilization training helped to alleviate the CLBP patients' low back pain [WMD=-1.32, 95%CI (-1.87--0.78), P< 0.01], and improve the patients' functional disorder [WMD=-0.84, 95%CI (-1.25--0.43), P< 0.01]; and Pilates helped to alleviate the CLBP patients' low back pain [WMD=-1.23, 95%CI (-1.44--1.01), P<0.01], but there was no strong evidence showing that it helped to improve the patients' functional disorder. Conclusions Yoga, Pilates and core stabilization training can help to alleviate CLBP patients' pain and improve their functional disorder, but yoga showes better effects than core stabilization training. There is no strong evidence showing that Pilates can help to improve CLBP patients' functional disorder, and therefore further research involving large samples from more clinical centers is needed.

Objective To investigate the correlation between Young′s elastic modulus (EI) using shear wave elastography (SWE) and liver pathology .Methods Liver biopsy was performed on 231 patients with chronic hepatitis B (CHB) under supersonic guidance ,and SWE with EI of liver was obtained concurrently .The correlation between measured liver stiffness and pathology was analyzed by using the liver pathology as golden standards .One‐way analysis of variance and Spearman rank correlation analysis were performed for the comparison between groups and correlation between two variables , respectively .Receiver operating characteristic (ROC) curve was used to explore the predictive value of shear modulus for the liver inflammation grades and fibrosis stages .Results The EI medians of different liver inflammation grades were 6 .78 kPa (G1) ,7 .30 kPa (G2) ,9 .93 kPa (G3) and 14 .93 kPa (G4) , respectively ,which were statistically different (H=55 .19 ,P<0 .01) .And EI medians of various fibrosis stages were 6 .62 kPa (S0 -S1) ,7 .15 kPa (S2) ,9 .78 kPa (S3) and 14 .62 kPa (S4) ,respectively , which were also significantly different (H=62 .14 ,P<0 .01) .EI was positively correlated with both liver inflammation grades (r=0 .454 6 ,P<0 .01) and liver fibrosis stages (r=0 .505 6 ,P<0 .01) .The areas under the ROC for G≥2 ,G≥3 and G=4 were 0 .68 (95% CI:0 .61 -0 .75) ,0 .77 (95% CI:0 .70 -0 .84) and 0 .85 (95% CI:0 .77-0 .92) ,respectively .The areas under the ROC for S≥2 ,S≥3 and S=4 w ere 0 .73 (95% C I:0 .66 -0 .79 ) ,0 .78 (95% C I:0 .72 -0 .85 ) and 0 .83 (95% C I:0 .75 -0 .91 ) , respectively .Conclusion The EI measured by SWE is correlated with liver pathology of CHB patients , which may be used to dynamically monitor the progress of liver fibrosis .

Using the animal model of acute myocardial infarction of rabbit after left coronary artery ligation, the authors studied the reltionship between the change of myocardial K~+/Na~+ ,Mg~(2+)/Ca~(2+), and Zn~(2+)/Cu~(2+) ratio and the time after acute myocardial infarction. The results demonstrated that. (1)the K+/Na~+ and Mg~(2+)/Ca~(2+)ratio dropped with prolongation of time myocardial ischemia. There was significant (P0.05)difference of Zn~(2+)/Cu~(2+) ratio between the experimental groups and the control group, but Zn~(2+)/Cu~(2+) ratio showed a tendency of dropping with prolongation of time of ischemia in the experimental group. At 120 min of myocardial ischemia,the Zn~(2+)/Cu~(2+) ratio was abour 1/2 as those at 15min, 30min, and 60min(P