Uric acid is the end product of purine catabolism. Elevated serum uric acid level triggers systemic inflammatory responses, leading to endothelial dysfunction and contributing to the pathogenesis and progression of pregnancy-related complications. There is no unified diagnostic criterion for gestational hyperuricemia (HUA), yet its prevalence has been increasing in recent years. Emerging evidence demonstrates that elevated maternal serum uric acid levels are not only closely associated with gestational diabetes mellitus and hypertensive disorders of pregnancy, but may also exert adverse effects on intrauterine fetal development and long-term offspring health. This review synthesizes recent advances in research on the impact of gestational HUA on offspring health. A clearer understanding of the detrimental effects and underlying mechanisms is essential for refining clinical practices and improving maternal and neonatal health outcomes.

Uric acid is the end product of purine catabolism. Elevated serum uric acid level triggers systemic inflammatory responses, leading to endothelial dysfunction and contributing to the pathogenesis and progression of pregnancy-related complications. There is no unified diagnostic criterion for gestational hyperuricemia (HUA), yet its prevalence has been increasing in recent years. Emerging evidence demonstrates that elevated maternal serum uric acid levels are not only closely associated with gestational diabetes mellitus and hypertensive disorders of pregnancy, but may also exert adverse effects on intrauterine fetal development and long-term offspring health. This review synthesizes recent advances in research on the impact of gestational HUA on offspring health. A clearer understanding of the detrimental effects and underlying mechanisms is essential for refining clinical practices and improving maternal and neonatal health outcomes.