Purpose: This study aimed to synthesize qualitative research findings on factors influencing medication adherence in individuals with schizophrenia. Methods: This study used the qualitative meta-synthesis method proposed by Thomas and Harden to categorize results based on the ecological model. A systematic literature review of nine databases, including international (CINAHL, PubMed, and Web of Science) and domestic (DBpia, KCI, KISS, KoreaMed, RISS, and ScienceON) databases, was conducted from November 5 to December 4, 2024 to identify qualitative studies on medication adherence among South Korean adults aged 19 years or older who were diagnosed with schizophrenia. Results: Three studies on medication adherence in individuals with schizophrenia identified five key themes within the ecological model, encompassing both barriers and facilitators. These themes emerged across different factors, including intrapersonal (barriers: lack of insight and perceived burden of taking psychiatric medication; facilitators: acceptance of medication as treatment), interpersonal (facilitators: supportive systems), and community factors (barriers: stigma related to the use of psychiatric medication). Conclusion These findings highlight the need for a comprehensive, multifactor approach to improving medication adherence in individuals with schizophrenia. This study also provides foundational data for the development of targeted interventions to enhance treatment adherence in these individuals.

Purpose: This study aimed to synthesize qualitative research findings on factors influencing medication adherence in individuals with schizophrenia. Methods: This study used the qualitative meta-synthesis method proposed by Thomas and Harden to categorize results based on the ecological model. A systematic literature review of nine databases, including international (CINAHL, PubMed, and Web of Science) and domestic (DBpia, KCI, KISS, KoreaMed, RISS, and ScienceON) databases, was conducted from November 5 to December 4, 2024 to identify qualitative studies on medication adherence among South Korean adults aged 19 years or older who were diagnosed with schizophrenia. Results: Three studies on medication adherence in individuals with schizophrenia identified five key themes within the ecological model, encompassing both barriers and facilitators. These themes emerged across different factors, including intrapersonal (barriers: lack of insight and perceived burden of taking psychiatric medication; facilitators: acceptance of medication as treatment), interpersonal (facilitators: supportive systems), and community factors (barriers: stigma related to the use of psychiatric medication). Conclusion These findings highlight the need for a comprehensive, multifactor approach to improving medication adherence in individuals with schizophrenia. This study also provides foundational data for the development of targeted interventions to enhance treatment adherence in these individuals.

Purpose: This study aimed to synthesize qualitative research findings on factors influencing medication adherence in individuals with schizophrenia. Methods: This study used the qualitative meta-synthesis method proposed by Thomas and Harden to categorize results based on the ecological model. A systematic literature review of nine databases, including international (CINAHL, PubMed, and Web of Science) and domestic (DBpia, KCI, KISS, KoreaMed, RISS, and ScienceON) databases, was conducted from November 5 to December 4, 2024 to identify qualitative studies on medication adherence among South Korean adults aged 19 years or older who were diagnosed with schizophrenia. Results: Three studies on medication adherence in individuals with schizophrenia identified five key themes within the ecological model, encompassing both barriers and facilitators. These themes emerged across different factors, including intrapersonal (barriers: lack of insight and perceived burden of taking psychiatric medication; facilitators: acceptance of medication as treatment), interpersonal (facilitators: supportive systems), and community factors (barriers: stigma related to the use of psychiatric medication). Conclusion These findings highlight the need for a comprehensive, multifactor approach to improving medication adherence in individuals with schizophrenia. This study also provides foundational data for the development of targeted interventions to enhance treatment adherence in these individuals.

Purpose: This study aimed to synthesize qualitative research findings on factors influencing medication adherence in individuals with schizophrenia. Methods: This study used the qualitative meta-synthesis method proposed by Thomas and Harden to categorize results based on the ecological model. A systematic literature review of nine databases, including international (CINAHL, PubMed, and Web of Science) and domestic (DBpia, KCI, KISS, KoreaMed, RISS, and ScienceON) databases, was conducted from November 5 to December 4, 2024 to identify qualitative studies on medication adherence among South Korean adults aged 19 years or older who were diagnosed with schizophrenia. Results: Three studies on medication adherence in individuals with schizophrenia identified five key themes within the ecological model, encompassing both barriers and facilitators. These themes emerged across different factors, including intrapersonal (barriers: lack of insight and perceived burden of taking psychiatric medication; facilitators: acceptance of medication as treatment), interpersonal (facilitators: supportive systems), and community factors (barriers: stigma related to the use of psychiatric medication). Conclusion These findings highlight the need for a comprehensive, multifactor approach to improving medication adherence in individuals with schizophrenia. This study also provides foundational data for the development of targeted interventions to enhance treatment adherence in these individuals.

Chronic kidney disease (CKD)-associated pruritus is a severe distressing condition that frequently occurs in patients undergoing dialysis. In this study, the profile of the skin microbiome was analyzed to understand the underlying etiology and potential treatments. Methods: Seventy-six end-stage kidney disease (ESKD) patients (hemodialysis, 40; peritoneal dialysis, 36) and 15 healthy controls were enrolled and swabbed at three sites: back, antecubital fossa, and shin. The pruritus severity of the enrolled subjects was validated by the Worst Itch Numeric Rating Scale (WI-NRS), 5-D itch scale, and Uremic Pruritus in Dialysis Patients (UP-Dial). The 16S genebased metagenomics method was applied to skin microbiome analysis. Results: In the comparison of bacterial communities of ESKD patients and the control group, there was a significant difference on back. Specifically, the average composition ratio of the Cutibacterium in the back samples was significantly lower in ESKD patients than in healthy controls (p < 0.01). In further analysis of ESKD patients, Cutibacterium was significantly lower in the high pruritus group than in the low pruritus group (p < 0.05), even though other clinical parameters such as age, calcium-phosphorus product, and intact parathyroid hormone showed no significance difference between the groups. Conclusion: In ESKD patients, the skin microbiome of the back was significantly altered, and the severity of itching was related to the reduction of Cutibacterium. This research reveals the relationship between skin microbiota and CKD-associated pruritus in multiple skin sites for the first time. The results of this study suggest a potential data basis for the diagnosis and treatment of CKD-associated pruritus.

Recurrent respiratory papillomatosis (RRP) is a chronic disease related to human papillomavirus infection. The standard treatment of RRP is surgical resection of the lesion, but due to frequent recurrence, a combination of various adjuvant therapies has been attempted. Herein, we present the first case of RRP to whom intravenous cidofovir was administered as an adjuvant therapy in Korea. A 9-year-old boy was admitted due to hoarseness, stridor and breathing difficulty. At 10 months of age, he was diagnosed with RRP in the upper airway and thereafter he had repeatedly undergone surgical removal. During this hospitalization, papilloma was found again from the superior glottis to the inferior glottis and surrounding the trachea at the age of 9 years. In addition, well-defined nodular lesions were newly found on both lung fields, and a pathologic examination revealed a squamous papilloma with highgrade dysplasia, human papilloma virus types 6, 11, and 40 (low-risk type). Because of the frequent recurrence of papilloma in the upper airway as well as lung involvement, he underwent 38 injections of intravenous cidofovir for 2 years. During treatment, the intervals required for surgical removal of the mass causing upper airway obstruction were prolonged from an average of 37.3 to 74.6 days without serious side effects. However, intravenous cidofovir treatment had no effect on the lung lesion. This case shows that an intravenous cidofovir administration can be used as an adjuvant therapy in a child with RRP to relieve the upper airway obstruction, although this treatment does not cure the disease.