Migraine is a common neurological disorder with a complex pathogenesis that is currently not fully understood;however,the role of mitochondrial function in migraine pathogenesis has recently attracted widespread attention.This review considers the latest research progress on the relationship between mitochondrial dysfunction and migraine,including mitochondrial energy metabolism,oxidative stress,calcium homeostasis,and neuroinflammation.We introduce the epidemiological and clinical characteristics of migraine,and provide a detailed exploration of the key role of mitochondria in these processes.Mitochondrial dysfunction may lead to increased neuronal excitability,abnormal vasoconstriction,and inflammatory responses,thereby inducing migraine.Based on the evidence of mitochondrial involvement in the pathogenesis of migraine,we propose future research directions and potential treatment strategies,with the aim of providing new ideas for the prevention and treatment of migraine.

BACKGROUND:With the rapid development of the biomedical field in recent years,research on brain aging and mitochondrial dysfunction has gradually become an academic hotspot.However,there has yet to be a systematic bibliometric analysis in this field.OBJECTIVE:To comprehensively analyze the research progress in the field of brain aging and mitochondrial dysfunction,and review and summarize relevant literature in the past 20 years,aiming to reveal the current research status,hotspots,and development trends in this field.METHODS:Using the Web of Science Core Collection database as a literature search platform,all documents related to brain aging and mitochondrial dysfunction published from the database inception to May 7,2024 were collected.The CiteSpace 6.3.R1 visualization analysis tool was used to conduct a multi-dimensional in-depth analysis of the collected literature data,including country,institution,author,keywords,and co-cited literature,in order to reveal the research dynamics and cutting-edge hotspots in this field.RESULTS AND CONCLUSION:This study included 2 534 relevant documents and the number of publications in this field has been yearly increasing both domestically and internationally.The country with the highest number of publications is the United States(974 articles),followed by China(362 articles).At the institutional level,the University of California in the United States ranks first in terms of publication volume(117 articles).In terms of personal contributions,Professor Reddy P.Hemachandra from the Texas Tech Center for Health Sciences is the most prolific scholar in the field,while Professor Mattson MP from the National Institute on Aging in the United States is the most cited scholar.INT J MOL SCI is the most prolific journal in this field.High-frequency keywords include"oxidative stress,""mitochondrial dysfunction,""Alzheimer's disease,"and"Parkinson's disease."By analyzing the cutting-edge hotspots in this field,it was found that the focus of research has gradually shifted from the exploration of molecular mechanisms to the search for biomarkers that can be used for the early identification and diagnosis of neurodegenerative diseases.In addition,mitochondrial dysfunction is expected to serve as a clinical interventional target for brain aging-related neurodegenerative diseases.

Migraine is a common neurological disorder with a complex pathogenesis that is currently not fully understood;however,the role of mitochondrial function in migraine pathogenesis has recently attracted widespread attention.This review considers the latest research progress on the relationship between mitochondrial dysfunction and migraine,including mitochondrial energy metabolism,oxidative stress,calcium homeostasis,and neuroinflammation.We introduce the epidemiological and clinical characteristics of migraine,and provide a detailed exploration of the key role of mitochondria in these processes.Mitochondrial dysfunction may lead to increased neuronal excitability,abnormal vasoconstriction,and inflammatory responses,thereby inducing migraine.Based on the evidence of mitochondrial involvement in the pathogenesis of migraine,we propose future research directions and potential treatment strategies,with the aim of providing new ideas for the prevention and treatment of migraine.

BACKGROUND:With the rapid development of the biomedical field in recent years,research on brain aging and mitochondrial dysfunction has gradually become an academic hotspot.However,there has yet to be a systematic bibliometric analysis in this field.OBJECTIVE:To comprehensively analyze the research progress in the field of brain aging and mitochondrial dysfunction,and review and summarize relevant literature in the past 20 years,aiming to reveal the current research status,hotspots,and development trends in this field.METHODS:Using the Web of Science Core Collection database as a literature search platform,all documents related to brain aging and mitochondrial dysfunction published from the database inception to May 7,2024 were collected.The CiteSpace 6.3.R1 visualization analysis tool was used to conduct a multi-dimensional in-depth analysis of the collected literature data,including country,institution,author,keywords,and co-cited literature,in order to reveal the research dynamics and cutting-edge hotspots in this field.RESULTS AND CONCLUSION:This study included 2 534 relevant documents and the number of publications in this field has been yearly increasing both domestically and internationally.The country with the highest number of publications is the United States(974 articles),followed by China(362 articles).At the institutional level,the University of California in the United States ranks first in terms of publication volume(117 articles).In terms of personal contributions,Professor Reddy P.Hemachandra from the Texas Tech Center for Health Sciences is the most prolific scholar in the field,while Professor Mattson MP from the National Institute on Aging in the United States is the most cited scholar.INT J MOL SCI is the most prolific journal in this field.High-frequency keywords include"oxidative stress,""mitochondrial dysfunction,""Alzheimer's disease,"and"Parkinson's disease."By analyzing the cutting-edge hotspots in this field,it was found that the focus of research has gradually shifted from the exploration of molecular mechanisms to the search for biomarkers that can be used for the early identification and diagnosis of neurodegenerative diseases.In addition,mitochondrial dysfunction is expected to serve as a clinical interventional target for brain aging-related neurodegenerative diseases.

Objective To investigate the regulatory effect of Fuling Xingren Gancao granules(FXG)on macrophage polarization in atherosclerosis(AS)model mice.Methods ApoE-/-mice were used to construct an AS model and RAW264.7 macrophages were used to construct a polarized cell model.The total area of aortic plaques and the degree of aortic stenosis were detected by Oil red O and hematoxylin and eosin staining,respectively.Expression levels of the M1 polarization factors inducible nitric oxide synthase(iNOS)and chemokine ligand 2(CCL2),as well as the M2 macrophage factors Arg-1,YM1,and CD206,and the phosphorylation levels of signal transducer and activator of transcription(STAT3)in vitro and in vivo were detected by polymerase chain reaction and Western blot.Results FXG significantly reduced the total area of aortic plaques in ApoE-/-mice,decreased the expression levels of the M1 macrophage polarization factors iNOS and CCL2,and increased the expression levels of the M2 macrophage polarization factors Arg-1 and YM1(P＜0.05).STAT phosphorylation levels were decreased in the model mice and M1 macrophages,but were upregulated after FXG intervention(P＜0.05).The STAT3 inhibitor Stattic partially eliminated the regulatory effect of FXG on iNOS and Arg-1(P＜0.05).Conclusions FXG has an inhibitory effect on the progression of AS,via targeting STAT3 to regulate macrophage polarization.