OBJECTIVE: The relationship between sodium intake and cardiovascular (CV) events remains unconfirmed. Therefore, we carried out a systematic review and dose-response meta-analysis for evaluating the potential impact of 24-hour sodium excretion on CV risk. Besides, 24-hour sodium excretion was used to replace daily sodium diet intake. METHODS: We searched ISI Web of Science, Embase, PubMed, and the Cochrane Library. Our study included cohort studies reporting hazard ratio ( HR). The random-effects model was used for summarizing the total relative risks ( RRs) between the included studies. In addition, the generalized least-squares regression was employed to fit the study model. RESULTS: A total of 9 studies involving 645,006 participants were included in this study. A significant non-linear relationship was observed between sodium excretion and CV events ( P _{non-linearity} < 0.001). In studies collecting 24-h urine samples, the sodium excretion and CV events risk were associated linearly ( RR: 1.04; 95% CI: 1.01, 1.07). CONCLUSION In a linear dose-response manner, every 1 g increase in sodium intake was associated with an increased risk of CV events up to 4%. Further studies are required to validate our conclusions further.
Humans ; Urinalysis ; Sodium Radioisotopes ; Cardiovascular Diseases/epidemiology* ; Sodium, Dietary/adverse effects*

OBJECTIVE: The aim of the study was to compare the diagnostic performances of F-18 sodium fluoride positron emission tomography/computed tomography (bone PET/CT) and bone scintigraphy (BS) for the detection of thyroid cancer bone metastasis. MATERIALS AND METHODS: We retrospectively enrolled 6 thyroid cancer patients (age = 44.7 ± 9.8 years, M:F = 1:5, papillary:follicular = 2:4) with suspected bone metastatic lesions in the whole body iodine scintigraphy or BS, who subsequently underwent bone PET/CT. Pathologic diagnosis was conducted for 4 lesions of 4 patients. RESULTS: Of the 17 suspected bone lesions, 10 were metastatic and 7 benign. Compared to BS, bone PET/CT exhibited superior sensitivity (10/10 = 100% vs. 2/10 = 20%, p = 0.008), and accuracy (14/17 = 82.4% vs. 7/17 = 41.2%, p < 0.025). The specificity (4/7 = 57.1%) of bone PET/CT was not significantly different from that of BS (5/7 = 71.4%, p > 0.05). CONCLUSION: Bone PET/CT may be more sensitive and accurate than BS for the detection of thyroid cancer bone metastasis.
Adult ; Bone Neoplasms/*radiography/secondary ; Bone and Bones/*radiography ; Contrast Media/*chemistry ; Female ; Fluorine Radioisotopes/chemistry ; Humans ; Male ; Middle Aged ; Positron-Emission Tomography ; Retrospective Studies ; Sodium Fluoride/*chemistry ; Thyroid Neoplasms/*pathology ; Tomography, X-Ray Computed ; Whole Body Imaging

OBJECTIVETo observe the influence of (99m)Tc-pertechnetate on radioactive iodine uptake (RAIU) in patients with Graves' disease (GD) hyperthyroidism after thyroid scintigraphy.

METHODSTotally 40 patients in whom thyrotoxicosis was diagnosed at Peking Union Medical College Hospital from 2013 March to May were recruited, and RAIU were performed in all patients. Gamma-count rates at 1 h,25 h,49 h,73 h and 169 h were examined respectively after intravenous injection of 185 MBq (5mCi)of (99m)Tc-pertechnetate. The counts of (99m)Tc and (131)I as well as effective half-life of (99m)Tc (Teff (99m)Tc) were calculated respectively according to the half-life formula. The ratio of (99m)Tc to background counts (1200) was calculated as a reference value to evaluate biokinetics of (99m)Tc.The relationship between the effective half-life of (99m)Tc(Teff (99m)Tc) and the level of free triiodothyronine (FT3), free thyroxine (FT4), and effective half-life of (131)I (Teff (131)I)were also evaluated.

RESULTSAfter intravenous injection of (99m)Tc-pertechnetate, (99m)Tc counts at 1h, 25h, 49h, 73h and 169h was (440.16±247.35)×10(4), (11.37±10.67)×10(4), (0.13±0.36)×10(4), (-0.1±0.19)×10(4), respectively, and the ratio of (99m)Tc to background at 1h, 25 h, and 49 h was 3668, 94.75, and 1.08, respectively. The Teff (99m)Tc was (4.41±0.49)h. Inverse correlations were noted between the effective half-life of Teff (131)I and level of FT3 (r=-0.503, P=0.003) and FT4 (r=-0.516, P=0.002), while no significant correlation was found between the Teff (99m)Tc and FT3, FT4 as well as the Teff (131)I.

CONCLUSIONSTeff (99m)Tc is 4.41h, (99m)Tc-pertechnetate thyroid imaging does not influence RAIU three days after injection of (99m)Tc-pertechnetate. Teff (99m)Tc shows no correlation with the thyroid hormone level and RAIU of Graves's hyperthyroidism.

Adult ; Female ; Graves Disease ; diagnostic imaging ; Humans ; Iodine Radioisotopes ; metabolism ; Male ; Middle Aged ; Radionuclide Imaging ; Sodium Pertechnetate Tc 99m ; Thyroid Gland ; diagnostic imaging ; Thyroxine ; analysis ; Triiodothyronine ; analysis

OBJECTIVE: Na18F bone positron emission tomography (bone PET) is a new imaging modality which is useful for the evaluation of bone diseases. Here, we compared the diagnostic accuracies between bone PET and bone scan for the detection of bone metastasis (BM). MATERIALS AND METHODS: Sixteen cancer patients (M:F = 10:6, mean age = 60 +/- 12 years) who underwent both bone PET and bone scan were analyzed. Bone PET was conducted 30 minutes after the injection of 370 MBq Na18F, and a bone scan was performed 3 hours after the injection of 1295 MBq 99mTc-hydroxymethylene diphosphonate. RESULTS: In the patient-based analysis (8 patients with BM and 8 without BM), the sensitivities of bone PET (100% = 8/8) and bone scan (87.5% = 7/8) were not significantly different (p > 0.05), whereas the specificity of bone PET (87.5% = 7/8) was significantly greater than that of the bone scan (25% = 2/8) (p < 0.05). In the lesion-based analysis (43 lesions in 14 patients; 31 malignant and 12 benign), the sensitivity of bone PET (100% = 31/31) was significantly greater than that of bone scan (38.7% = 12/31) (p < 0.01), and the specificity of bone PET (75.0% = 9/12) was also significantly higher than that of bone scan (8.3% = 1/12) (p < 0.05). The receiver operating characteristic curve analysis showed that bone PET was significantly more accurate than the bone scan in the patient (p = 0.0306) and lesion (p = 0.0001) based analyses. CONCLUSION: Na18F bone PET is more accurate than bone scan for BM evaluation.
Adult ; Aged ; Aged, 80 and over ; Area Under Curve ; Bone Neoplasms/*radionuclide imaging/*secondary ; Diphosphonates/diagnostic use ; Female ; Fluorine Radioisotopes/diagnostic use ; Fluorodeoxyglucose F18/diagnostic use ; Humans ; Male ; Middle Aged ; Multimodal Imaging/methods ; Organotechnetium Compounds/diagnostic use ; Positron-Emission Tomography/*methods ; Retrospective Studies ; Sensitivity and Specificity ; Sodium/diagnostic use ; Tomography, X-Ray Computed/methods

Among the serious complications associated with radioiodine therapy (RAI) for thyroid cancer, cerebral edema is uncommon and has been reported previously in cases of swelling of brain metastases. This case is of a patient with papillary thyroid carcinoma who complained of nausea and vomiting after RAI and was then found unconscious the next day. Laboratory results showed electrolyte imbalances including hyponatremia and cranial imaging only revealed cerebral edema, and she regained consciousness after sodium correction. The etiology of the cerebral edema here is likely multifactorial - due to hyponatremia from hypothyroidism, aggravated by vomiting, copious water intake and a low sodium diet.

Human ; Female ; Adult ; Brain ; Brain Edema ; Carcinoma ; Consciousness ; Diet, Sodium-restricted ; Electrolytes ; Hyponatremia ; Hypothyroidism ; Iodine Radioisotopes ; Nausea ; Sodium ; Thyroid Neoplasms ; Vomiting

OBJECTIVETo investigate the biodistribution of (18)-NaF as an imaging agent for position emission tomography (PET) in rat models of osteoporosis.

METHODSOsteoporosis was induced in 10 rats via injection with an excess of dexamethasone phosphate sodium, and the biodistribution of (18)-NaF in the rats was studied, with another 10 normal rats as the control group. (18)-NaF PET was also performed in 8 healthy volunteers, and the uptakes of (18)-F- in the bone tissues were measured.

RESULTSCompared with the control rats, the osteoporotic rats showed significantly decreased (18)-F- uptake, especially in the femoral neck, lumbar vertebrae, the 7th rib and the tibia (P<0.05). Dynamic chest PET scanning in the volunteers revealed obvious (18)-F- uptake in the spine, ribs and humerus 20 s after injection of the imaging agent. (18)-F- uptake significantly increased with time in the bones, reaching the peak level 60 min after the injection, and whole-body PET at this point demonstrated obvious skeletal (18)-F- uptake, with high skeletal-to-muscle (STM) ratio that averaged 8.12.

CONCLUSION(18)-NaF is an excellent skeletal imaging agent for clinical skeletal blood flow and metabolism measurements. The uptake of (18)-NaF has significant difference between normal and osteoporotic bone tissues, indicating the value of (18)-NaF PET for study of osteoporosis.

Adult ; Animals ; Bone and Bones ; diagnostic imaging ; metabolism ; Female ; Fluorine Radioisotopes ; pharmacokinetics ; Humans ; Male ; Osteoporosis ; diagnostic imaging ; Positron-Emission Tomography ; methods ; Radiopharmaceuticals ; pharmacokinetics ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Sodium Fluoride ; pharmacokinetics ; Tissue Distribution

OBJECTIVE: Pullulan derivatives (PD) can be used to make self-assembled hydrogel nanoparticles which are responsive to ionic strength. The aim of this study is to evaluate the potential of PD as a retaining carrier of radioisotope inside tumors. MATERIALS AND METHODS: Four types of PD were evaluated which included pullulan acetate (PA), succinylated PA (SPA), PA-DTPA and SPA-DTPA conjugates. They were radiolabeled with Tc-99m. Labelling efficiencies were determined at 30 min, 1, 2, 4 and 12 hours after radiolabeling. CT-26 colon cancer cells were subcutaneously injected into Balb/c mice. After 2 weeks of subcutaneous injection, Tc-99m-labelled PD (Tc-99m-PD) were injected into the tumors. Whole body images of mice were obtained at 30 min, 1, 2, and 12 hr after intratumoral injection. All twenty mice were grouped into four groups by largest diameter; control A (largest diameter = 5 mm, n = 5), control B (largest diameter = 10 mm, n = 5), pullulan A (largest diameter = 5 mm, n = 5), pllulan B (largest diameter = 10 mm, n = 5). Dynamic images were obtained for 1 hour after intratumoral injection. Static images were obtained at 1 hr, 2 hr, 3 hr and 4 hr after intratumoral injection with Tc-99m pertechnetate and Tc-99m-PA. Target-to-background ratios and retention rates were calculated. RESULTS: Labeling efficiencies of PA, SPA, PA-DTPA and SPA-DTPA were 94.5 +/- 5.9%, 97.8 +/- 3.5% 94.2 +/- 3.8%, and 92.5 +/- 6.2%, respectively (p> 0.05). Percent retention rates (%RR) of PA and PA-DTPA were significantly higher than those of control, however, those of SP-DTPA and SPA became similar to control at 4 and 12 hr, respectively. %RR of pullulan A and pullulan B at 1, 4 and 8 hr is significantly higher than that of control (p < 0.05). However, %RR between pullulan A and pullulan B were similar. CONCLUSION: The ionic strength dependent PD-nanoparticles are retained in the tumor. No difference of %RR according to tumor size was noted. Therapeutic application of PD labelled with beta- or alpha- emitting radionuclides can be expected.
Animals ; Body Image ; Colonic Neoplasms ; Hydrogel ; Injections, Subcutaneous ; Mice* ; Nanoparticles ; Osmolar Concentration ; Radioisotopes ; Sodium Pertechnetate Tc 99m

The detection of renal disorders now involves a series of complicated diagnostic procedure such as radiologic pyelography, function studies in laboratory and others These add up to a painful, expensive, and time consuming experience for the patient, others may be spared the discomfort of unnecessary. Consequently, the development of methods for preliminary screening of patients is significant both with regard to the diagnostic information obtained and to the selection of those patients requiring complete urologic work up. In particular, a reliable screening test is important in establishing or ruling out renal pathology as an underlying factor in hypertension the finding of a disorder of one kidney in the hypertensive patient may be at indication for nephrectomy or other surgical measures of renal artery. A positive preliminary investigation warrants precise diagnosis by aortography and confirmation by individual renal clearance tests. Finally the primary objective of the screening test is the restriction of more exacting procedures such as aortography with its inherent risk of serious complications to the preoperative evaluation of a demonstrated lesions. The visualization of an internal structure by determining the spatial distribution of a gamma radiation-emitting isotope was started in 1950 when Cassen and his associates utilized newly developed scintillation counters to print mechanically the spatial distribution of radioactive iodine in the thyroid gland. Visual and functional informations referable to each kidney separately may be obtained by radioisotopes and tracer or by scanning techniques rapidly and without trauma. The renogram or tracing of the renal uptake and excretion of a labeled contrast medium is a clinically useful measure of renal vascularity, tubular cell function, and the patency of the upper urinary passage, and especially valuable as a screening test for the hypertensive patient with suspected unilateral disease of the kidney. Similarly, scanning images are achieving an important place in medical diagnosis of irregularities effecting the kidneys and other specific organs. Radioactive contrast media, such as I131 labeled diodrast, miokon, Urokon, or hippuran have been widely used for renal function studies. They are entirety unsatisfactory, however, for renal scintillation scanning because they are rapidly excreted by the kidneys without retention in the renal parenchyma in contrast but mercurial diuretics labeled with radioactive mercury are concentrated to a high degree in the renal tubular cells, chiefly in the cortex, prior to their appearance in the urine (Borghgraef 1956.MaAfee and Wagner 1960). Following the report of these letter writers, scintillation scanning of the kidney after the intravenous injection of Hg Neohydrin have been widely used in urological clinics for preliminary screening method of renal disease such as delineating the parenchyma of the kidney and space-occupying lesions by Krevitz, Berk, and others(Reley, Blahd, Mins, Morgan, Kuhl, Bender, Simmons, Blau, Kim) and remained several problems which is anticipated to improvements in resolution for further using of renal scan. The main purposes of this experimental study were: 1) to learn at which period of time it is best to visualize the renal parenchyma following the intravenous administration of Hg Neohydrin, 2) to learn the minimal detectable size of space-occupying lesion within the kidney phantom, and 3) to compare the renal scan with aortography and pyelography on various period of hydronephrosis for visualization of renal parenchyma, 4) to compare the renal scan with aortography on various degree of narrowing of the renal artery for visualization of renal parenchyma. MATERIALS AND METHODS: These experiments have been performed on 17 normal adult mongrel dogs anesthetized with intravenous injection of sodium amycal. Ofthese 3 dogs were used for determining the optimal time of visualization of the renal parenchyma. 8 dogs for the visualization of the parenchyma of hydronephrotic kidneys as created by partial ligation of the left ureter for the period of 1. 2. 3 and 4 weeks as devided in 4 groups, and 6 dogs were used for the visualization of the narrowed renal artery produced by partial obstruction to various degrees. A wax phantom of the kidney was utilized for the study of detectable minimal size of the intrarenal space occupying lesion, the phantom measures 12.5 X 6.2 X 3.5cm. All animals underwent renal scintiacan received 80 microcuri of Hg neohydrin intravenously, they were placed in a prone position and the study was carried out using a Nuclear-Chicago dual scanner with a 62-hole coarse focusing collimator containing a 3x3 inch sodium iodide crystal, the collimator was passed back and forth over the target are at a rate of 12-15cm, per minute. The scan usually required 30 minutes for complete of scan. The pyelography was performed in retrograde way with 30% diodrast injected through ureteral catheter and the amount of dye injected was adjusted to replace the urine from renal pelvis. The aortography was performed by transfemoral arterial catheterization technique as described by Seldinge. RESULTS: 1. The optimal opacification period of renal parenchyma after injection of Hg 203 neohydrin was found to range from 1 to 6 hours 2. By kidney phantom study it was demonstrated that the space-occupying lesion measuring 2cm. in diameter can not be detected on scan. While the lesion measuring 3cm, or more can be successfully visualized. 3. The effect of partial obstruction of the ureter upon the renal scintiscan for visualization of renal parenchyma was not. dependable, the renal scintiscan continued to appear up to at least the 2 weeks after partial obstruction of ureter whereas the retrogredepyelography and aortography showed the definite picture of hydronephrosis to various degree. 4. The renal scan is inconsistent in many instances of renal artery stenosis, the scan showed a diminished concentration of mercury in the kidney with stenotic main renal artery and complete failure of visualization of the renal substance in cases with completely obstructed renal artery. 5. It is possible to demonstrate the value and usefulness of renal scan of Hg neohydrin as a routine preliminary screening test for renal pathology, the alteration of the concentration of the mercury can might be expected to give additional information.
Administration, Intravenous ; Adult ; Animals ; Aortography ; Catheterization ; Catheters ; Contrast Media ; Diagnosis ; Diuretics ; Dogs* ; Humans ; Hydronephrosis ; Hypertension ; Injections, Intravenous ; Iodine ; Iodopyracet ; Kidney ; Kidney Pelvis ; Ligation ; Mass Screening ; Nephrectomy ; Pathology ; Prone Position ; Radioisotopes ; Renal Artery ; Renal Artery Obstruction ; Scintillation Counting ; Sodium ; Sodium Iodide ; Thyroid Gland ; Ureter ; Urinary Catheters ; Urography