BACKGROUND: Ethylene oxide (EO) is a widely utilized industrial compound known to pose health hazards. Although its carcinogenic characteristics have been thoroughly investigated, recent findings indicate possible links to respiratory disease. The correlation between EO exposure and the likelihood of developing obstructive sleep apnea (OSA) in individuals remains unclear. The study aimed to explore the association between EO exposure and OSA within the broader US population. METHODS: From 2015 to 2020, 4355 participants were analyzed cross-sectionally in the National Health and Nutrition Examination Survey (NHANES). As the primary indicator of EO exposure, hemoglobin adducts of EO (HbEO) were used in this study. The relationship between EO exposure and OSA prevalence was assessed using weighted multivariable regression analysis and smoothing curve fitting. Using subgroup analysis and interaction tests, we investigated whether this association remained consistent across populations. RESULTS: According to the study, higher HbEO level was positively correlated with a higher prevalence of OSA. Compared to the first HbEO quartile (Q1), participants within the highest quartile (Q4) presented a higher OSA prevalence in the fully model (OR = 1.32, 95% CI: 1.08-1.62, P = 0.01, P for trend = 0.001). This correlation was particularly evident among females and individuals who are insufficiently physically active. CONCLUSIONS This research found a positive relationship between the extent of exposure to EO and OSA prevalence among a representative sample of Americans.
Humans ; Sleep Apnea, Obstructive/chemically induced* ; Female ; Male ; Middle Aged ; Adult ; Cross-Sectional Studies ; Prevalence ; Ethylene Oxide/toxicity* ; United States/epidemiology* ; Nutrition Surveys ; Aged ; Environmental Exposure/adverse effects* ; Young Adult

OBJECTIVE: To build up a steady and credible animal model on obstructive sleep apnea-hypopnea syndrome (OSAHS) with New Zealand rabbit. METHOD: Ten New Zealand rabbit were divided into two groups (A and B, 5 for each). Group A was treated by injecting Dimethiconum from exterior. Group B was blank. EEG, snoring and oxygen-saturation were recorded by PSG after operation. Examination was repeated two weeks later and one month later. CT was done in the operation and two weeks later. Animals were sacrificed three months later and the Dimethiconum in the body was used for examination with light microscopy. RESULT: Group A showed apnea or hypopnea and decreasing SaO2 after operation. The changes in group A were more obvious at two weeks and one month. CONCLUSION A steady and credible animal model of OSAHS has been built. The model provides a tool to study the pathogenesy and pathophysiology of OSAHS.
Animals ; Apnea ; chemically induced ; physiopathology ; Disease Models, Animal ; Oxygen ; metabolism ; Rabbits ; Sleep Apnea, Obstructive ; chemically induced ; physiopathology ; Snoring ; physiopathology