As a chronic metabolic disease,type 2 diabetes poses a significant threat to human health with increasing incidence.An increasing number of studies confirm that the pathogenesis of diabetes is closely related with alterations in multiple cellular signaling pathways.Although numerous studies have reported that traditional Chinese medicine compounds prevent diabetes by modulating cell signaling pathways,asystematic review of the mechanism of action of traditional Chinese medicine compounds in modulating cell signaling pathways is still lacking.Therefore,this paper summarizes the research of type 2 diabetes prevention and treatment,which was found mainly related to the signaling pathways such as PI3K/AKT,AMPK,MAPK,NF-κB,PPAR,TGF-β.This family of signaling pathways can treat type 2 diabetes by inhibiting pancreatic islet cell apoptosis,protecting pancreatic β-cell function,ameliorating insulin resistance,inhibiting hepatic gluconeogenesis,promoting glycogen synthesis,attenuating inflammation,and resisting oxidative stress.At the same time,we analyze the problems in current research and the future development trend,in order to provide a scientific theoretical basis for the drug development and clinical application of traditional Chinese medicine compound in the prevention and treatment of diabetes.

Diabetes mellitus is a chronic metabolic disease characterized by elevated blood glucose due to insufficient insulin secretion or insulin resistance.According to traditional Chinese medicine,diabetes mellitus is classified as"Xiaoke disease"in Chinese medicine,and its basic pathogenesis is yin deficiency and fluids.With the continuous improvement and development of traditional Chinese medicine theory,more and more doctors generally believe that"hot"runs through the occurrence and development of diabetes and the heat-clearing method is the key to the treatment of diabetes.The theory of the efficacy of traditional Chinese medicine believes that heat-clearing Chinese medicine has the effect of clearing heat and reducing fire,and its own effect of reducing heat and preserving Yin,which is in line with the principle of traditional Chinese medicine treatment of diabetes.Therefore,in this paper,we summarize the research progress on the role and mechanism of heat clearing herbs in the prevention and treatment of diabetes,mainly related to protection of pancreatic β-cell function,improvement of insulin resistance,inhibition of glucosidase activity,reduce the inflammatory response,relieve oxidative stress and regulation of intestinal flora,and analyze the problems and development trend of the current research,in order to provide a scientific and theoretical basis for the drug development and clinical application of heat clearing traditional Chinese medicine in the prevention and treatment of diabetes.

Diabetes mellitus is a chronic metabolic disease characterized by elevated blood glucose due to insufficient insulin secretion or insulin resistance.According to traditional Chinese medicine,diabetes mellitus is classified as"Xiaoke disease"in Chinese medicine,and its basic pathogenesis is yin deficiency and fluids.With the continuous improvement and development of traditional Chinese medicine theory,more and more doctors generally believe that"hot"runs through the occurrence and development of diabetes and the heat-clearing method is the key to the treatment of diabetes.The theory of the efficacy of traditional Chinese medicine believes that heat-clearing Chinese medicine has the effect of clearing heat and reducing fire,and its own effect of reducing heat and preserving Yin,which is in line with the principle of traditional Chinese medicine treatment of diabetes.Therefore,in this paper,we summarize the research progress on the role and mechanism of heat clearing herbs in the prevention and treatment of diabetes,mainly related to protection of pancreatic β-cell function,improvement of insulin resistance,inhibition of glucosidase activity,reduce the inflammatory response,relieve oxidative stress and regulation of intestinal flora,and analyze the problems and development trend of the current research,in order to provide a scientific and theoretical basis for the drug development and clinical application of heat clearing traditional Chinese medicine in the prevention and treatment of diabetes.