Amblyopia, a common cause of unilateral visual impairment, has traditionally been treated in early childhood, with treatment considered ineffective beyond the critical period of visual maturation. This case report presents an 18 -year-old male patient with anisometropic amblyopia who demonstrated significant visual improvement following a combination of optical correction and part -time occlusion therapy. Despite starting treatment after the conventional critical period, the patient experienced marked gains in visual acuity and stereopsis, challenging the notion that amblyopia patching treatment is ineffective in adolescence. This case underscores the importance of reassessing treatment timeline and considering continued therapeutic interventions beyond the traditionally accepted age limit.

Abdullah and Bakar Brunei International Medical Journal 2025;21:137-143 Brunei International Medical Journal Empowering Brunei’s Health Professionals in Research Amid Clinical Demands: Post Workshop Report and Reflection Siti Nurliyana ABDULLAH1* and Afwi BAKAR2

Orbital lymphoma is a rare malignancy, with diffuse large B-cell lymphoma (DLBCL), a less common but more aggressive subtype. It commonly manifests with progressive proptosis and visual disturbances mimicking conditions such as thyroid eye disease, benign masses, or idiopathic orbital inflammation. A 69-year-old woman presented with right eye proptosis secondary to a progressively enlarging temporal orbital mass. Her condition rapidly deteriorated, with worsening visual acuity, increased proptosis, and elevated intraocular pressure. Imaging revealed an extraconal orbital lesion with widespread systemic involvement, including lytic lesions, hypermetabolic lymph nodes, splenomegaly and skeletal involvement. Fine needle aspiration confirmed DLBCL. She was treated with six cycles of CHOP chemotherapy (Cyclophosphamide, Hydroxydaunorubicin, Oncovin, and Prednisone) and intrathecal methotrexate. Her symptoms resolved, and vision was restored. This case highlights the importance of considering orbital lymphoma as a potential indicator of disseminated disease, and prompt diagnosis and interventions can restore visual functions.