The fundiform ligament and penile suspensory ligament (PSL) are essential for maintaining prepubic curvature and stabilizing erections. PSL dissection is a key step in penile lengthening surgery for micropenis; however, the precise origin and insertion of the fundiform ligament, as well as the insertion of the PSL, remain subjects to debate. In this study, 34 embalmed male cadavers without pathology or prior pelvic or perineal surgery were dissected layer by layer from the lower abdominal wall to the penile base. The fundiform and PSL were identified, and their origin, insertion, morphology, length, and vascular associations were documented. Four distinct shapes of the fundiform ligament were identified: double, triangular, Y-shaped, and irregular type, with the double type being most common. The majority originated from the linea alba, while some arose from Scarpa’s fascia or both, inserting distally into the superficial penile fascia. The external pudendal artery was observed near its insertion in 56% of cases. The PSL consistently exhibited a triangular configuration, with an average depth of 27.4±5.7 mm along the pubic symphysis. The angle between the pubic margin and penile shaft margin measured 58.6°±9.7°. The deep dorsal vein of the penis was identified at the deep margin of the PSL in 53% of specimens.These findings provide detailed anatomical insights into the penile suspensory apparatus, highlighting structural variations, origins, and relationships with adjacent vascular structures. Further surgical validation is required to establish their clinical implications in penile lengthening procedures.

Knowledge of the superficial radial nerve (SRN) relationship and anatomic variations of the first extensor compartment (1st EC) will contribute to a better outcome of de Quervain tenosynovitis treatment. We dissected 87 embalmed cadaveric wrists to determine the relationship of the SRN, the 1st EC length, distance from the proximal and distal 1st EC borders to radial styloid process (RSP), abductor pollicis longus (APL) and extensor pollicis brevis (EPB) tendon slip numbers, and the presence of septum. Our results revealed SRN crossing over the 1st EC in 59.5%. The lateral branch of the superficial radial nerve to the 1st EC midline in most cases (61.9%) except for one specimen, where lateral antebrachial cutaneous nerve was the closest. Distances from proximal and distal 1st EC borders to the RSP were 19.7±4.1 mm and 7.6±1.8 mm, respectively. Extensor retinaculum (ER) width over 1st EC (1st EC length) was 14.8±3.2 mm. Complete and incomplete septa were found in 17.2%, and 42.5%, respectively. The most frequent APL tendon slip number in the compartment was two in overall 47 specimens (54.0%). Almost all compartments (85 specimens; 97.7%) contained one EPB tendon slip. We detected bilateral EPB absence in one cadaver. Moreover, we recorded a tendon slip from extensor pollicis longus traveling into 1st EC bilaterally in one cadaver and observed the EPB muscle belly extension into 1st EC in 9 wrists. Awareness of 1st EC anatomic variations would be essential for successful surgical and nonsurgical outcomes.

Peripheral neuropathy is one of the major side effects of cisplatin; however, effective treatments are lacking. Curcumin is a polyphenol found in the root of Curcuma longa and has been shown neuroprotective against several neurological diseases. Nevertheless, its effects on cisplatin neuropathy remain unclear. This study aimed to clarify this issue by inducing neuropathy in the rats with intraperitoneal injection of cisplatin 2 mg/kg twice a week for 5 consecutive weeks. Curcumin 200 mg/kg/day was given by gavage to a group of cisplatin-treated rats during these five weeks. The results showed that cisplatin induced thermal hypoalgesia in the 5th week which could be prevented by curcumin. In the 5th and 8th weeks, sciatic motor nerve conduction velocity was reduced in the cisplatin compared with the control groups. Curcumin significantly attenuated this deficit. Morphometric analysis of L4 dorsal root ganglia from the cisplatin group revealed nuclear and nucleolar atrophy including loss of neurons in the 8th week. These alterations were significantly blocked by curcumin. Moreover, curcumin also ameliorated the reduced myelin thickness in the sciatic nerve of cisplatin-treated rats. Taken together, our findings suggest the favorable effects of curcumin on both functional and structural abnormalities in cisplatin neuropathy. Future studies are needed to clarify the exact underlying mechanisms.
Animals ; Atrophy ; Cisplatin ; Curcuma ; Curcumin* ; Ganglia, Spinal ; Injections, Intraperitoneal ; Myelin Sheath ; Neural Conduction ; Neurons ; Peripheral Nervous System Diseases ; Rats ; Sciatic Nerve