Giant Condyloma Acuminata or Buchke Lowenstein tumors: A Rare Manifestation of Human Papillomavirus (HPV) Infection Giant condylomata acuminata (GCA) or Buchke Lowenstein tumors are rare manifestation of Human Papillomavirus (HPV) infection. They are usually considered the intermediate state between benign condyloma and malignant squamous cell carcinoma. Usually these manifestations are related to HPV 6 & 11 infections and if left untreated can grow larger and is locally aggressive. The most important treatment method is surgical excision which differs from benign condyloma acuminatum cases due to its high degree of malignancy. This report presented a case of immunodeficient patient post renal transplant, with a presentation of large penile wart with histopathological findings of condyloma acuminata.