Objective To analyze the clinical characteristics of patients with Streptococcus anginosus group(SAG)infected brain abscess and provide a reference basis for the clinical diagnosis and treatment of this disease.Methods The clinical information of 59 patients with brain abscess with SAG in Guangdong Sanjiu Brain Hospital from January 2016 to October 2023 was collected for retrospective statistical analysis.Results Among the 59 patients with brain abscess,there were 52(88.14%)male and 7(11.86%)female.Among 59 cases of SAG,there were 32(54.24%)in the Str.intermedius group,21(35.59%)in the Str.constellatus group and 6(10.17%)in the Str.anginosus group.The age of Str.intermedius group was less than that of Streptococcus constellatus group(36.75±20.06 years vs 50.43±16.17 years),and the difference was statistically significant(t=2.614,P<0.05).The common clinical symptom was headache,while the probability of fever was greater in the Str.intermedius group compared to the Str.constellatus group(t=4.174,P<0.05).Abscesses were commonly solitary and were located in the parietal and frontal lobes of the brain.Patients with Str.constellatus had a greater probability of developing mixed infections compared to patiens with Str.intermedius(57.14%vs 9.38%)with significant differences(t=14.257,P<0.05).Glycopeptide(vancomycin)plus carbapenem(meropenem)combination regimen was the most commonly used in both empiric and targeted dosing were 64.41%and 52.54%,respectively.No strains resistant to common antibiotics were identified.Conclusion The SAG causing brain abscesses are mainly Str.intermedius and Str.constellatus,and the age,symptoms and infection patterns of patients with brain abscesses caused by the two bacteria were different.SAG did not appear to be drug-resistant in the clinic,and the clinic could reasonably evaluate and adjust the anti-infection regimen based on the drug sensitivity results.

Objective: To explore the relationship between the parent-child relationship perceived by parents and students of junior high school and students internalization problems, so as to provide a pathway for the prevention and control of students internalization problems. Methods: In June 2023, a convenience cluster sampling method and a matching method between students and their fathers/mothers were used to select 965 pairs of students and their fathers (or mothers) from three junior high schools in Guizhou Province, and the Middle School Student s Parent-Child Relationship Questionnaire (parent and student edition) and the Strengths and Difficulties Questionnaire (student edition) were used to measure the perception of parent-child relationship by parents and students and the internalization problems of students. The response surface analysis method was used to analyze the relationships between parents and students perceptions of parent-child relationship and students internalization problems. Results: The comparison of standardized scores revealed that 58.44% of parents and junior high school students had different perceptions of parent-child relationship. After controlling for students gender, students grade, and parents education level, the results showed that when the parent-child relationship perceived by parents and students was congruent, the students internalization problems increased with the decrease of parent-child relationship level ( a 1=-0.43, 95%CI=-0.62 to -0.25, P <0.05). When the parent-child relationship perceived by parents and students was incongruent, and the parent-child relationship perceived by parents was higher than that of students, students internalization problems were more ( a 3=-0.36, 95%CI=-0.51 to -0.19, P <0.05). Conclusions Students internalization problems are closely related to perceptions of parent-child relationship. Improving the quality of the parent-child relationship and paying attention to the differences in perception of the parent-child relationship are helpful for evaluating and intervening in the internalization problems of junior high school students.

Objective To analyze the clinical characteristics of patients with Streptococcus anginosus group(SAG)infected brain abscess and provide a reference basis for the clinical diagnosis and treatment of this disease.Methods The clinical information of 59 patients with brain abscess with SAG in Guangdong Sanjiu Brain Hospital from January 2016 to October 2023 was collected for retrospective statistical analysis.Results Among the 59 patients with brain abscess,there were 52(88.14%)male and 7(11.86%)female.Among 59 cases of SAG,there were 32(54.24%)in the Str.intermedius group,21(35.59%)in the Str.constellatus group and 6(10.17%)in the Str.anginosus group.The age of Str.intermedius group was less than that of Streptococcus constellatus group(36.75±20.06 years vs 50.43±16.17 years),and the difference was statistically significant(t=2.614,P<0.05).The common clinical symptom was headache,while the probability of fever was greater in the Str.intermedius group compared to the Str.constellatus group(t=4.174,P<0.05).Abscesses were commonly solitary and were located in the parietal and frontal lobes of the brain.Patients with Str.constellatus had a greater probability of developing mixed infections compared to patiens with Str.intermedius(57.14%vs 9.38%)with significant differences(t=14.257,P<0.05).Glycopeptide(vancomycin)plus carbapenem(meropenem)combination regimen was the most commonly used in both empiric and targeted dosing were 64.41%and 52.54%,respectively.No strains resistant to common antibiotics were identified.Conclusion The SAG causing brain abscesses are mainly Str.intermedius and Str.constellatus,and the age,symptoms and infection patterns of patients with brain abscesses caused by the two bacteria were different.SAG did not appear to be drug-resistant in the clinic,and the clinic could reasonably evaluate and adjust the anti-infection regimen based on the drug sensitivity results.

The triple negative breast cancer is one of importance in clinical subtypes of breast cancer, which is easy to recur and metastasis, and its prognosis is very poor.Radiotherapy, as an effective method for breast cancer,can reduce the risk of local recurrence.This article elaborates its characteristics,the progress of ra-diotherapy in the breast conserving surgery and modified radical mastectomy in triple negative breast cancer,when is the appropriate time for radiotherapy and radiotherapy sensitization,and hope that it will be helpful to the treat-ments.