Porcine epidemic diarrhea virus(PEDV)is a highly pathogenic porcine enteric coronavir-us.Porcine epidemic diarrhea(PED)caused by this virus has become widespread around the world since it was reported in the 1970s,caused huge harm to the global breeding industry.The viral structural protein is crucial for invasion,replication,and evasion of natural immunity.The non-structural protein has diverse functions including inhibiting host cell gene expression and counter-acting the host antiviral response.Additionally,the auxiliary protein is essential for virus replica-tion,virulence regulation,and immune evasion.This article focuses on elucidating the genome structure of PEDV and the key roles of its encoded proteins in virus replication and interaction with host cells,offering insights into its pathogenic mechanisms.

Porcine epidemic diarrhea virus(PEDV)is a highly pathogenic porcine enteric coronavir-us.Porcine epidemic diarrhea(PED)caused by this virus has become widespread around the world since it was reported in the 1970s,caused huge harm to the global breeding industry.The viral structural protein is crucial for invasion,replication,and evasion of natural immunity.The non-structural protein has diverse functions including inhibiting host cell gene expression and counter-acting the host antiviral response.Additionally,the auxiliary protein is essential for virus replica-tion,virulence regulation,and immune evasion.This article focuses on elucidating the genome structure of PEDV and the key roles of its encoded proteins in virus replication and interaction with host cells,offering insights into its pathogenic mechanisms.