Elderly patients with primary membranous nephropathy (PMN) exhibit significant prognostic heterogeneity and poor tolerance to immunotherapy. However, there is a lack of early prognostic prediction tools specifically for this population. This study aimed to develop a prognostic prediction model applicable to elderly PMN patients.

Magnetic surgery,as an emerging discipline,utilizes the principle of “non-contact” magnetic force to drive the innovative development of surgical technology. Magnetic compression anastomosis (MCA),a significant branch of magnetic surgical technology,demonstrates notable advantages in reducing surgical trauma,shortening operation time,and lowering the risk of complications,particularly in the reconstruction of digestive tract and vascular anastomoses. Compared to traditional suturing and mechanical anastomoses,MCA avoids defects such as the “pinhole effect” and “foreign body reaction”,leveraging the advantages of magnetic force′s non-contact nature,gradient variation, uniformity,and directionality to significantly reduce the risks of anastomotic bleeding,stenosis,and fistula. However,the widespread adoption of MCA still faces challenges,including the biological safety of magnetic materials,optimization of magnet design,intelligent application,and large-scale clinical validation. To address these,it is necessary to further standardize clinical operation procedures,enhance safety assessments,promote interdisciplinary integration,and accelerate technological iteration and translation of research findings,with the aim of facilitating broader clinical application of MCA for the benefit of patients.

Objective To investigate the status of feeding intolerance in patients with enteral nutrition after lung transplantation and analyze its influencing factors,to provide a reference for formulating a reasonable enteral nutrition plan and improving patients'nutritional status.Methods Convenient sampling method was used to retrospectively collect the clinical data of 115 patients who received enteral nutrition support after lung transplantation and were hospitalized in the ICU of a tertiary hospital in Guangdong Province from August 2022 to November 2023.According to the occurrence of feeding intolerance during ICU hospitalization,the patients were divided into a feeding tolerance group and a feeding intolerance group.Univariate and logistic regression analysis were used to analyze the influencing factors of feeding intolerance patients with enteral nutrition after lung transplantation.Results Within 7 days of initiating enteral nutrition,a total of 63 patients developed feeding intolerance,with an incidence of 54.78％.Among them,the incidence of feeding intolerance was relatively high within 1 to 3 days after initiating enteral feeding.The clinical manifestations of feeding intolerance were diarrhea,bloating,gastric retention,vomiting/regurgitation,among which the diarrhea was the highest incidence(87.30％).Logi-stic regression analysis showed that intraoperative net balance volume(OR=0.999),intraoperative blood transfusion(OR=1.001)volume and diabetes history(OR=0.170)were independent influencing factors for feeding intolerance in patients with enteral nutrition after lung transplantation(P＜0.05).Conclusion There was a high incidence of feed-ing intolerance in patients with enteral nutrition after lung transplantation.Patients undergoing lung transplantation who have a high net intraoperative fluid balance,receive a low volume of intraoperative blood transfusions,and have a history of diabetes are at a lower risk of developing feeding intolerance when receiving postoperative enteral nutrition.When starting enteral nutrition,medical staff should dynamically evaluate the risk factors of feeding intolerance,screen high-risk patients as early as possible,and formulate reasonable enteral nutrition programs to improve the nutritional status of patients and promote their rehabilitation.

Brown adipose tissue(BAT), a metabolically active organ, not only plays a pivotal role in thermogenesis, but also exerts endocrine effects that regulate both its own metabolic processes and the function of various other organ systems. These effects are primarily mediated by brown adipose tissue-derived factors, or batokines. Recent advances in the understanding of batokine types, target organs, and underlying mechanisms have highlighted their significant role in the crosstalk between BAT and other organs. This review focuses on the various batokines secreted by BAT and their involvement in regulating interactions with key target organs such as the liver, cardiovascular system, skeletal muscle, and nervous system. By examining the specific functions and molecular mechanisms of these factors, this review aims to offer novel insights and suggest potential research directions for the prevention and treatment of related metabolic diseases.

Magnetic surgery technology leverages the principle of "non-contact" magnetic force, demonstrating revolutionary potential in the field of digestive surgery. It has been widely applied in areas such as gastrointestinal anastomosis, esophageal atresia recanalization, and biliary stricture treatment. Magnetic surgery techniques can be categorized into the following six major types based on their application methods and principles: magnetic compression technology, magnetic navigation technology, magnetic anchoring technology, magnetic levitation technology, magnetic tracing technology, and magnetic drive technology. These innovative surgical techniques significantly simplify surgical operations, solve complex and difficult problems, and improve clinical treatment outcomes. Meanwhile, the deepening application of magnetic surgery technology requires further standardization of clinical operation and quality control standards, reinforcement of safety research, and acceleration of multidisciplinary integration and development. The authors review the develop-ment history of magnetic surgical technology and offer a perspective on its future, highlighting the core concept of surgical innovation. The authors also summarize the clinical applications of magnetic surgery in the treatment of digestive diseases, as well as its key theoretical and technological advance-ments. Looking forward, the authors anticipate that interdisciplinary collaboration and intelligent development, with the aim of further promoting the continuous innovation of surgical technology and enhancing clinical treatment value.

After ostomy surgery, patients lose the ability to control their anal sphincter, relying on ostomy pouches for excretion. Convex baseplates offer several advantages, including preventing leakage, reducing the risk of stoma and peripheral skin complications, and adapting to the dynamic stoma shapes caused by peristaltic expansion and contraction of the stoma. This article reviews the structure and features of convex baseplates, usage considerations, existing challenges, and future prospects, aiming to provide a reference for the standardized clinical use of convex baseplates and to improve patient health outcomes.

Objective To investigate the status of feeding intolerance in patients with enteral nutrition after lung transplantation and analyze its influencing factors,to provide a reference for formulating a reasonable enteral nutrition plan and improving patients'nutritional status.Methods Convenient sampling method was used to retrospectively collect the clinical data of 115 patients who received enteral nutrition support after lung transplantation and were hospitalized in the ICU of a tertiary hospital in Guangdong Province from August 2022 to November 2023.According to the occurrence of feeding intolerance during ICU hospitalization,the patients were divided into a feeding tolerance group and a feeding intolerance group.Univariate and logistic regression analysis were used to analyze the influencing factors of feeding intolerance patients with enteral nutrition after lung transplantation.Results Within 7 days of initiating enteral nutrition,a total of 63 patients developed feeding intolerance,with an incidence of 54.78％.Among them,the incidence of feeding intolerance was relatively high within 1 to 3 days after initiating enteral feeding.The clinical manifestations of feeding intolerance were diarrhea,bloating,gastric retention,vomiting/regurgitation,among which the diarrhea was the highest incidence(87.30％).Logi-stic regression analysis showed that intraoperative net balance volume(OR=0.999),intraoperative blood transfusion(OR=1.001)volume and diabetes history(OR=0.170)were independent influencing factors for feeding intolerance in patients with enteral nutrition after lung transplantation(P＜0.05).Conclusion There was a high incidence of feed-ing intolerance in patients with enteral nutrition after lung transplantation.Patients undergoing lung transplantation who have a high net intraoperative fluid balance,receive a low volume of intraoperative blood transfusions,and have a history of diabetes are at a lower risk of developing feeding intolerance when receiving postoperative enteral nutrition.When starting enteral nutrition,medical staff should dynamically evaluate the risk factors of feeding intolerance,screen high-risk patients as early as possible,and formulate reasonable enteral nutrition programs to improve the nutritional status of patients and promote their rehabilitation.

Magnetic surgery technology leverages the principle of "non-contact" magnetic force, demonstrating revolutionary potential in the field of digestive surgery. It has been widely applied in areas such as gastrointestinal anastomosis, esophageal atresia recanalization, and biliary stricture treatment. Magnetic surgery techniques can be categorized into the following six major types based on their application methods and principles: magnetic compression technology, magnetic navigation technology, magnetic anchoring technology, magnetic levitation technology, magnetic tracing technology, and magnetic drive technology. These innovative surgical techniques significantly simplify surgical operations, solve complex and difficult problems, and improve clinical treatment outcomes. Meanwhile, the deepening application of magnetic surgery technology requires further standardization of clinical operation and quality control standards, reinforcement of safety research, and acceleration of multidisciplinary integration and development. The authors review the develop-ment history of magnetic surgical technology and offer a perspective on its future, highlighting the core concept of surgical innovation. The authors also summarize the clinical applications of magnetic surgery in the treatment of digestive diseases, as well as its key theoretical and technological advance-ments. Looking forward, the authors anticipate that interdisciplinary collaboration and intelligent development, with the aim of further promoting the continuous innovation of surgical technology and enhancing clinical treatment value.

After ostomy surgery, patients lose the ability to control their anal sphincter, relying on ostomy pouches for excretion. Convex baseplates offer several advantages, including preventing leakage, reducing the risk of stoma and peripheral skin complications, and adapting to the dynamic stoma shapes caused by peristaltic expansion and contraction of the stoma. This article reviews the structure and features of convex baseplates, usage considerations, existing challenges, and future prospects, aiming to provide a reference for the standardized clinical use of convex baseplates and to improve patient health outcomes.

Brown adipose tissue(BAT), a metabolically active organ, not only plays a pivotal role in thermogenesis, but also exerts endocrine effects that regulate both its own metabolic processes and the function of various other organ systems. These effects are primarily mediated by brown adipose tissue-derived factors, or batokines. Recent advances in the understanding of batokine types, target organs, and underlying mechanisms have highlighted their significant role in the crosstalk between BAT and other organs. This review focuses on the various batokines secreted by BAT and their involvement in regulating interactions with key target organs such as the liver, cardiovascular system, skeletal muscle, and nervous system. By examining the specific functions and molecular mechanisms of these factors, this review aims to offer novel insights and suggest potential research directions for the prevention and treatment of related metabolic diseases.