Objective:Based on the health ecological model, this paper systematically explores the influencing factors of mild cognitive impairment among the elderly herders in Nanshan pastoral area of Xinjiang, and provides the basis for local medical institutions to formulate prevention and control strategies for mild cognitive impairment among the elderly herders.Methods:A total of 1 145 valid questionnaires were collected, all of them were permanent herdsmen aged over 60 years in Nanshan pastoral area of Xinjiang were selected from June 2022 to February 2023 by stratified cluster random sampling method in a cross-sectional survey. Under the guidance of health ecological model, the research variables were included from five dimensions: physiology, psychology, behavioral lifestyle, social network and medical and health environment, and questionnaires were conducted. SPSS 23.0 was used for chi-square test and binary Logistic regression to analyze the influencing factors of mild cognitive impairment in elderly herders.Results:There were 564 males and 581 females with age of (70.84 ± 5.69) years old in the study. The prevalence rate of mild cognitive impairment among elderly herdsmen in Nanshan pastoral area of Xinjiang was 36.1%(413/1 145). Binary Logistic regression analysis showed that: personal monthly income (1 000-2 999 yuan)( OR = 0.583, 95% CI 0.366 - 0.926, P<0.05), education level (junior high school and above)( OR = 0.479, 95% CI 0.315 - 0.728, P<0.01) were the protective factors for mild cognitive impairment among the elderly herdsmen in Nanshan pastoral area. Hypertension ( OR = 1.842, 95% CI 1.256 - 2.702, P<0.01), dyslipidemia ( OR = 1.449, 95% CI 1.069 - 1.964, P<0.05) and chronic pain ( OR = 1.549, 95% CI 1.082 - 2.216, P<0.05) were the risk factors of mild cognitive impairment in elderly herders in Nanshan pastoral area. Conclusions:The prevalence rate of mild cognitive impairment among elderly herders in Nanshan pastoral area of Xinjiang is high, so it is necessary to carry out mild cognitive impairment screening as soon as possible, especially focusing on people suffering from hypertension, dyslipidemia and chronic pain, and making intervention plans to delay the occurrence and development of mild cognitive impairment and improve the quality of life of elderly herders.

Objective:To explore the application effect of blended learning on the teaching of nursing research course for undergraduate nursing students.Methods:From March to July 2019, a total of 118 undergraduate nursing students from Batch 2016 of a university in Xinjiang were collected in this study and divided into two groups randomly: the experimental group ( n = 60) and the control group ( n = 58). At the end of the course, the final examination scores of the nursing students were compared, and questionnaires were used to evaluate the critical thinking, self-directed learning ability and satisfaction of nursing students. SPSS 21.0 was used for independent-sample t-test and chi-square test. Results:After the implementation of the course, the scores of nursing research theory and practice of nursing students in the experimental group were (78.97±6.57) points and (83.02±3.50) points respectively, which were better than those of nursing students in the control group (75.48±7.76) points and (81.48±3.86) points. The total scores of critical thinking ability and self-directed learning ability of nursing students in the experimental group (294.67±25.15) and self-directed learning ability (277.67±30.84) were higher than those in the control group (222.03±18.77) and (203.81±33.19). The satisfaction degree of nursing students in the experimental group (93.33%) was better than that in the control group (60.34%), with statistical significance ( P<0.05). Conclusion:The application of blended learning in nursing research teaching can improve the final examination results of nursing students, and contribute to the improvement of nursing students' critical thinking ability, self-directed learning ability and course satisfaction.

Objective:To explore the willingness to engage in geriatric nursing services of students in geriatric related majors in universities of Xinjiang Uygur Autonomous Region, China (Xinjiang for short) , and analyze its influencing factors, so as to provide a reference for cultivating the geriatric nursing service personnel in Xinjiang.Methods:From September 2019 to July 2020, 976 students in geriatric related majors (the nursing major and geriatric service and management major) from 2 universities, a medical university and a vocational university in Xinjiang, were selected as the research object. Students were investigated with the Students' Willingness to Engage in Geriatric Nursing Services Questionnaire, and 50 students were interviewed with the structured interview.Results:Among 976 university students in geriatric related majors, 606 (62.09%) were willing to engage in geriatric nursing services. Logistic regression analysis showed that attitudes towards the aged, registered residence, experience of caring for the aged, living with the aged, attention to geriatric nursing information, and views on the prospects of geriatric nursing services were the influencing factors of students' willingness to engage in geriatric nursing services with a statistical difference ( P<0.05) . The results of grey relation analysis showed that the driving strength of the influencing factors of the willingness to engage in geriatric nursing services of students in geriatric related majors from strong to weak was views on the prospects of geriatric nursing services (the relation index was 0.944) and attitudes toward the aged (the relation index was 0.828) , experience of caring for the aged (the relation index was 0.763) , attention to geriatric nursing information (the relation index was 0.658) , living with the aged (the relation index was 0.600) and the registered residence (the relation index was 0.563) . Conclusions:The most critical influencing factor for students in geriatric related majors in Xinjiang universities to engage in geriatric nursing services is their views on the prospects of geriatric nursing services and their attitudes towards the aged. Universities should further strengthen the discipline construction and curriculum reforms of geriatric related majors, pay attention to the education of career prospects, cultivate a positive attitude towards the aged, and increase the willingness of students to engage in geriatric nursing services.

Aim To investigate the effect of phenyle-thanol glycosides from Cistanche tubulosa(CPhGs) on the proliferation and activation of rrPDGF-BB induced HSC and their target points for resisting hepatic fibro-sis,to elucidate the molecular mechanism in molecular level, and provide basic data for the further develop-ment of new drugs. Methods HSCs were cultivated by CPhGs with different concentrations ( 0 , 3. 91 , 7. 81 , 15. 63 , 31. 25 , 62. 50 , 125. 00 , 250. 00 , and 500 mg ·L-1 ) and IC50 of CPhGs was determined. CPhGs with different concentrations ( 25 , 50 , 75 , 100 mg · L-1 ) were selected, and after the cells were stimulated with rrPDGF-BB, cell proliferation was determined by MTT. ERK1/2 ,α-SMA, c-fos, c-jun and Collagen I mRNA and Erk1/2 ,P-Erk1/2 and CollagenⅠprotein ex-pressions were assayed by RT-PCR and Western blot. Results CPhGs of ( 50 ~100 ) mg · L-1 concentra-tions groups could effectively inhibit rrPDGF-BB-medi-ated proliferation(P<0. 05) and CPhGs of(25~100) mg·L-1 concentrations groups had no significant cyto-toxicity( P >0. 05 ) . CPhGs of ( 25 ~100 ) mg · L-1 concentrations groups could inhibit ERK1/2 ,α-SMA,c-fos, c-jun and CollagenⅠmRNA levels, and also ob-viously inhibited Erk1/2 ,P-Erk1/2 and Collagen Ⅰ pro-tein expression on HSC. Conclusions CPhGs has the protective effect against hepatic fibrosis. The mecha-nism of this process may involve the interference with PDGF/ERK1/2 signaling pathway and inhibiting the activation and proliferation of HSC.

OBJECTIVE To study the anti-fibrotic effect of Cistanche phenylethanoid glycosides (CPhG) in bovine serum albumin (BSA)-induced liver fibrosis in rats and its possible mechanism METHODS Seventy-five SD rats were randomly divided into six groups:normal control(distilled water-treated),model(BSA-treated),positive drug〔BSA-treated+compound Biejiarangan tablets(BJRG) 0.6 g·kg-1〕,and BSA-treated+CPhG(0.125,0.25 and 0.5 g·kg-1)groups. There were thirteen rats in each BSA-treated+CPhG(0.125,0.25 and 0.5 g·kg-1)group and twelve rats in other groups. Subcutaneous injection and tail vein injection of BSA immunity were used to induce the rat liver fibrosis model. Meanwhile, different therapeutic drugs were ig adminstered to rats. After the experimental period,rats were fasted for 12 h prior to 10%chloral hydrate administration and immediately euthanized. The liver was weighed to calculate the liver index. Glutamic-pyruvic transaminase (GPT),glutamic-oxalactic transaminase (GOT),alkaline phosphatase(ALP),total protein(TP)and albumin(ALB)were evaluated by the Mind-Ray automatic biochemical analyzer. The density of hydroxyproline (HyP) in liver tissues was determined using a spectrophotometric method according to the kit′s instructions. Histopathological changes and expressions of typeⅠ and typeⅢcollagens in liver tissues were also determined by immunohisto?chemical staining. RESULTS Compared with the normal control group,collagen fibers of liver tissues in the model group extended their links and enveloped the entire lobule,causing lobular structural damage and the formation of pseudolobules. The liver index(P<0.05),GPT,GOT,ALP,TP and ALB serum levels(P<0.05),HyP content(P<0.01)were significantly increased,so was the expression of typeⅠcollagens and typeⅢcollagens(P<0.01)in the model group. Compared with model group,various doses (0.125,0.25 and 0.5 g · kg-1) of CPhG significantly reduced the BSA-induced elevation of the liver index;GPT,GOT,ALP,TP and ALB serum levels(P<0.05),and HyP content decreased(P<0.01);the morphology of the pathological tissue sections was close to that of the normal control group,and CPhG significantly reduced the expression of two types of collagens(P<0.01). CONCLUSION CPhG can significantly reduce the degree of BSA-induced liver fibrosis in rats. The mechanism may be associated with down-regulation of two types of collagens and suppression of the activation of hepatic stellate cells.

OBJECTIVETo provide reference data on frequency and distribution of bone islands (BIs) and investigate their relationship with age, gender, and localization.

METHODSA population who received a pretreatment and at least one follow-up panoramic radiograph in the Department of Oral Radiology, West China Hospital of Stomatology, Sichuan University, were selected for this retrospective study. A sample population of 29,556 patients (12,824 males and 16,732 females) with different dental complaints and ages ranging from 8 to 80 years (mean age: 23.95 years) were included.

RESULTSIn the radiographic evaluation, BIs appeared as localized, well-defined, non-expansile, radiopaque masses which were round, elliptic, or irregular in shape. Their sizes varied from a few millimeters to about 2 cm in diameter. A total of 598 radiopacities were detected, and 545 patients of 29,556 patients (1.84%) had BIs. Among subjects with multiple lesions, 49 patients had 2 BIs and 2 patients had 3 BIs. The BIs had immense mandibular predilection, with presentation primarily in the premolar/molar region. The condition appeared to have no tendencies based on sex.

CONCLUSIONRecognition of BIs variation is significant in dental examinations.

Objective Through the community health management of hypertension , to determine the input and output , change the knowledge , attitude, practice ( KAP) of hypertension patients and put forward the reasonable suggestions of antihypertensive treatment in order to reduce hypertensive patients 'medical expenses . Methods By random cluster sampling method , we selected 809 hypertension patients , over 18 years old, from two communities in Urumqi .414 patients were in the management group and 395 patients were in the control group.The health management the cost benefit was analyzed by the change of patient 's KAP, medical expenses and so on.Results For the knowledge and behavior changes , 17.94% patients in the management group and 3.04%patients in the control knew the classification of blood pressure (Z=-5.688,P=0.000).The master of normal range of blood pressure (Z=-11.927,P=0.000), knowledge of obesity (χ2 =15.608,P=0.000) and knowledge of risk factors (χ2 =-17.677,P=0.000) between groups had significant differences (P<0.01).The total drug expenses of the management group and the control group were (1 583.88 ±981.24) and (1 923.90 ±1 523.81) yuan, respectively;the total hospitalization expenses of the management group and the control group were (10 725.77 ±11 688.26) and (15 327.03 ±10 280.42) yuan, respectively, the differences were significant (t=2.14,2.75, respectively;P<0.05).The costs of patients taking the drug and other costs in the management group were lower than the control group , the differences were significant ( P <0.01 ). Conclusions Hypertension health management can obtain a good cost benefit , reduce hypertension sickness cost, and improve quality of life .

Objective To study the critical thinking situation among different nationalities undergraduate nursing students and explore its training in basic nursing teaching , so as to provide the evidence for the teaching reform .Methods Routine teaching methods and case teaching methods were respectively used in ‘basic nursing ’ teaching among different nationalities undergraduate nursing students , and the Critical Thinking Disposition Inventory ( CTDI-CV ) was used to investigate their critical thinking abilities . Results Among 69 undergraduate nursing students in the study , gender:55 female students (79.7%),and 14 male students(20.3%), nationality:37 minorities(53.6%) ,and 32 Han nationality(46.4%),and more than 91.3%of students approved the importance of critical thinking training .Before and after the study , critical thinking total scores of different nationalities respectively were (251.21 ±22.94) and (256.65 ±31.46), both less 280 ,and the dimensions the score of which were more than 40 were self-confidence and thirst for knowledge . The critical thinking total scores of male students before and after the study were respectively higher than those of female students [(254.28 ±34.20) vs (250.87 ±21.68), (289.71 ±54.62) vs (252.91 ±25.89)].The dimensions the score of which were more than 40 in male students respectively were analysis , self-confidence , thirst for knowledge , and systemic capacity , and that in female students only was self-confidence dimension before and after the study .Conclusions Undergraduate nursing students have high approval for the training of critical thinking , however their critical thinking level is in medium .Critical thinking total score of male students is higher than that of female students , and male students have positive tendency of critical thinking after the study,which show that reformed teaching methods can significantly improve the male students ’ critical thinking while no significant effectiveness is found in improving the entirety critical thinking of undergraduate nursing students.More explore and lots work need to do for the critical thinking training in the future .

Objective To provide reference data on frequency and distribution of bone islands (BIs) and investigate their relationship with age, gender, and localization. Methods A population who received a pretreatment and at least one follow-up panoramic radiograph in the Department of Oral Radiology, West China Hospital of Stomatology, Sichuan University, were selected for this retrospective study. A sample population of 29 556 patients (12 824 males and 16 732 females) with different dental complaints and ages ranging from 8 to 80 years (mean age: 23.95 years) were included. Results In the radio-graphic evaluation, BIs appeared as localized, well-defined, non-expansile, radiopaque masses which were round, elliptic, or irregular in shape. Their sizes varied from a few millimeters to about 2 cm in diameter. A total of 598 radiopacities were detected, and 545 patients of 29 556 patients (1.84%) had BIs. Among subjects with multiple lesions, 49 patients had 2 BIs and 2 patients had 3 BIs. The BIs had immense mandibular predilection, with presentation primarily in the premolar/molar region. The condition appeared to have no tendencies based on sex. Conclusion Recognition of BIs variation is significant in dental examinations.

Objective To detect Chlamydia trachomatis phage Vp1 gene in clinical swab specimens and anti-Vp1 antibodies in serum specimens.MethodsCervical and urethral swab as well as serum specimens were collected from attendees to the sexually transmitted disease(STD) clinic in the Tianjin Institute of STD,during March 2008 to March 2011.PCR was conducted to detect chlamydial phage Vp1 gene in swab samples,enzyme linked immunosorbent assay(ELISA) and Western blot to detect anti-Vp1 antibody in sera.The swab specimens positive for Vp1 gene were subjected to cell culture followed by the detection of Vp1 protein with an immunofluorescence-based method.ResultsTotally,36 out of 1542 swab specimens turned out to be positive for Vp1 gene,and 23 out of 453 serum specimens for anti-Vp1 antibody.No positive results were obtained in the Vp1 gene-positive swab specimens by cell culture and immunofluorescence-based assay.ConclusionThe Vp1 gene of Chlamydial trachomatis phage and anti-Vp1 antibody are successfully detected from clinical swab and serum specimens respectively.