Objective:To explore the mechanism of how neurocognition affects social functioning through fa-cial emotion recognition in individuals with schizophrenia.Methods:Totally 203 patients with schizophrenia meet-ing the Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition(DSM-IV)diagnostic criteria were re-cruited,with an age of(40±12)years,an initial onset age of(24±8)years,scored(60.4±16.1)points on the Positive and Negative Syndrome Scale.Using the Personal and Social Performance Scale(PSP),the MATRICS Consensus Cognitive Battery(MCCB),and the Facial Emotion Recognition Test(FERT)to assess patients'social functioning,neurocognition,and facial emotion recognition abilities.Results:In the relationship between MCCB fac-tor scores and PSP dimensions scores,happy face recognition showed a mediating effect in socially useful activities dimension(ACME=0.021,P＜0.01),sad(ACME=-0.026,P＜0.05)and surprised face recognition(ACME=-0.017,P＜0.05)showed mediating effects in self-care dimension.Additionally,sad(ACME=-0.025,P＜0.05)and fearful face recognition(ACME=-0.025,P＜0.001)played a mediating role in disruptive and aggres-sive behavior dimensions.Conclusion:Facial emotion recognition in patients with schizophrenia may play a media-ting role in the neurocognitive mechanisms of social dysfunction,with different dimensions of social dysfunction be-ing associated with specific categories of emotions.

Objective:To explore the mechanism of how neurocognition affects social functioning through fa-cial emotion recognition in individuals with schizophrenia.Methods:Totally 203 patients with schizophrenia meet-ing the Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition(DSM-IV)diagnostic criteria were re-cruited,with an age of(40±12)years,an initial onset age of(24±8)years,scored(60.4±16.1)points on the Positive and Negative Syndrome Scale.Using the Personal and Social Performance Scale(PSP),the MATRICS Consensus Cognitive Battery(MCCB),and the Facial Emotion Recognition Test(FERT)to assess patients'social functioning,neurocognition,and facial emotion recognition abilities.Results:In the relationship between MCCB fac-tor scores and PSP dimensions scores,happy face recognition showed a mediating effect in socially useful activities dimension(ACME=0.021,P＜0.01),sad(ACME=-0.026,P＜0.05)and surprised face recognition(ACME=-0.017,P＜0.05)showed mediating effects in self-care dimension.Additionally,sad(ACME=-0.025,P＜0.05)and fearful face recognition(ACME=-0.025,P＜0.001)played a mediating role in disruptive and aggres-sive behavior dimensions.Conclusion:Facial emotion recognition in patients with schizophrenia may play a media-ting role in the neurocognitive mechanisms of social dysfunction,with different dimensions of social dysfunction be-ing associated with specific categories of emotions.

Objective:To explore the expression of Aurora Kinase A (AURKA) in hepatocellular carcinoma (HCC) and its prognostic value.Methods:mRNA expression profiles and clinical data of HCC patients were downloaded from the Cancer Genome Atlas (TCGA) database. Expression of AURKA mRNA in HCC patients of TCGA database from normal liver tissue and all tumor tissues, normal tissues adjacent to cancer and matched tumor tissues were analyzed, and then expression of AURKA to was investigated in HCC tissues and normal liver tissues in the Human Protein Atlas (HPA) database. According to the TNM stage information of HCC patients in TCGA database, expression of AURKA in different stages was analyzed. Kaplan-Meier method was used to analyze whether the high and low expression of AURKA in HCC patients of TCGA database (with the median as the cut-off value) was significantly related to the length of survival. The RNA-seq expression profile data of HCC patients in the public resource platform of the Kaplan-Meier Plotter website was used for external verification. Cox univariate and multivariate analysis were performed on the age, sex, degree of differentiation, TNM stage, and AURKA mRNA expression of TCGA database patients.Results:374 cases of HCC tumor tissues and 50 cases of adjacent normal liver tissues in the TCGA database were included. All HCC tumor tissues in the TCGA database compared with the paired adjacent tissues mRNA level of AURKA was significantly increased, and the protein level was also increased, the difference was statistically significant ( P<0.05); With the tumor TNM stage increase of AURKA mRNA expression showed a gradual upward trend, and the difference was statistically significant ( P<0.05); in the TCGA database HCC cohort, high expression of AURKA mRNA was associated with poor HCC prognosis, and was obtained in Kaplan Meier Plotter database. The difference was statistically significant ( P<0.05); Cox multivariate regression analysis showed that TNM stage ( HR=1.69, 95% CI: 1.37-2.10) and AURKA mRNA expression level ( HR=1.03, 95% CI: 1.01-1.10) are the independent prognostic factors of HCC patients. Conclusions:AURKA is highly expressed in HCC, which is associated with the poor prognosis of HCC. AURKA is an independent prognostic factor of HCC.

Objective:To investigate the public psychosocial status and regional differences of Chinese residents during the outbreak of the novel coronavirus pneumonia epidemic.Methods:A convenience sampling method was used to distribute online self-assessment tools of mental health including the Self-Reporting Questionnaire (SRQ-20), 9-item Patient Health Questionnaire (PHQ-9), Generalized Anxiety Disorder Scale (GAD-7) through WeChat and other self media platforms from January 30 to February 13, 2020. A total of 14 592 people from all over the country were evaluated on mental health. The positive detection rate was regarded as the primary outcome measure.Results:The positive detection rate of SRQ-20 was 33.2% (4 840/14 592), and that of the PHQ-9 was 53.5% (7 503/14 037), with 29.3% (4 115/14 037) for mild, 14.0% (1 967/14 037) for moderate and 10.1% (1 421/14 037) for severe depression. The positive detection rate of GAD-7 was 44.6% (6 196/13 904), with 27.8% (3 862/13 904) for mild, 10.2% (1 413/13 904) for moderate and 6.6% (921/13 904) for severe anxiety. Except for a few areas, the positive rates of these three scales were almost the same all over the country, and the anxiety level of the inhabitants in Hubei province (GAD-7:54.7%) was significantly higher than that in other provinces ( P<0.05). Conclusion:As a Public Health Emergency of International COVID-19 has brought obvious psychological impact to the nationwide people, with more prominent in anxiety and depression. The public is in a general group crisis in the early stage of the outbreak, especially in areas with serious epidemic situation. It is suggested that great attention should be paid to public mental health while fighting against the epidemic situation aiming at ensuring their life safety, so as to implement effective psychological assistance and timely psychological crisis intervention.

Objective:This study developed a localized facial emotion recognition test and tested its reliability and validity.Methods:Seven types of emotion were selected from the Chinese facial expression intensity grading picture library, each of which had 16 pictures. A total of 112 pictures formed the first edition of the test. Eighty-three normal controls were recruited to complete the test. Based on the results of the item analysis, 42 pictures were screened to form the final version of the test. After an interval of 4 weeks, 83 normal subjects were retested with the final version to determine the test-retest reliability. The Toronto Alexithymia Scale (TAS-20) and the MATRICS (measurement and treatment research to improve cognition in schizophrenia, which is an NIMH launched research program in 2003) Consensus Cognitive Battery (MCCB) were used as criterion-related validity reference. At the same time, the internal consistency reliability and the split-half reliability were analyzed. Additionally, 162 patients with schizophrenia were recruited to complete the final version of the test to test the discriminant validity.Results:(1) The formal Chinese facial Emotion Recognition Test consisted of seven types of emotion including happiness, anger, sadness, disgust, surprise, fear, and calm, each of which had 6 pictures, and a total of 42 pictures formed the final version of the test. The total average difficulty of the test was 0.76, and the total average differentiation was 0.30. (2) The internal consistency and split-half coefficients were 0.77 and 0.72, respectively. The test-retest reliability was 0.81. (3) There was a significant positive correlation between the judgment score of disgust emotion and working memory score and MCCB total score in normal controls ( r=0.572, P<0.01; r=0.426, P=0.028, respectively). Also beside, the total judgment score of all facial emotion categories was positively correlated with the working memory score and the MCCB total score ( r=0.431, P=0.022; r=0.432, P=0.024, respectively). (4) The recognition scores of other emotion categories in schizophrenics were significantly lower than those in normal controls (all P<0.05; the effect value ranged from 0.27 to 0.72), except for calm emotion. The judgment scores of the intensity of aversion, fear, and sadness in schizophrenics were significantly lower than those in normal controls (all P<0.05, the effect value ranged from 0.33 to 0.47). Conclusion:The emotion recognition test based on Chinese face developed in this study has good reliability and validity and can be used as a standardized evaluation tool for the recognition ability of facial emotion category and facial emotion intensity in patients with schizophrenia.

Objective:To investigate the public psychosocial status and regional differences of Chinese residents during the outbreak of the novel coronavirus pneumonia epidemic.Methods:A convenience sampling method was used to distribute online self-assessment tools of mental health including the Self-Reporting Questionnaire (SRQ-20), 9-item Patient Health Questionnaire (PHQ-9), Generalized Anxiety Disorder Scale (GAD-7) through WeChat and other self media platforms from January 30 to February 13, 2020. A total of 14 592 people from all over the country were evaluated on mental health. The positive detection rate was regarded as the primary outcome measure.Results:The positive detection rate of SRQ-20 was 33.2% (4 840/14 592), and that of the PHQ-9 was 53.5% (7 503/14 037), with 29.3% (4 115/14 037) for mild, 14.0% (1 967/14 037) for moderate and 10.1% (1 421/14 037) for severe depression. The positive detection rate of GAD-7 was 44.6% (6 196/13 904), with 27.8% (3 862/13 904) for mild, 10.2% (1 413/13 904) for moderate and 6.6% (921/13 904) for severe anxiety. Except for a few areas, the positive rates of these three scales were almost the same all over the country, and the anxiety level of the inhabitants in Hubei province (GAD-7:54.7%) was significantly higher than that in other provinces ( P<0.05). Conclusion:As a Public Health Emergency of International COVID-19 has brought obvious psychological impact to the nationwide people, with more prominent in anxiety and depression. The public is in a general group crisis in the early stage of the outbreak, especially in areas with serious epidemic situation. It is suggested that great attention should be paid to public mental health while fighting against the epidemic situation aiming at ensuring their life safety, so as to implement effective psychological assistance and timely psychological crisis intervention.

Objective:This study developed a localized facial emotion recognition test and tested its reliability and validity.Methods:Seven types of emotion were selected from the Chinese facial expression intensity grading picture library, each of which had 16 pictures. A total of 112 pictures formed the first edition of the test. Eighty-three normal controls were recruited to complete the test. Based on the results of the item analysis, 42 pictures were screened to form the final version of the test. After an interval of 4 weeks, 83 normal subjects were retested with the final version to determine the test-retest reliability. The Toronto Alexithymia Scale (TAS-20) and the MATRICS (measurement and treatment research to improve cognition in schizophrenia, which is an NIMH launched research program in 2003) Consensus Cognitive Battery (MCCB) were used as criterion-related validity reference. At the same time, the internal consistency reliability and the split-half reliability were analyzed. Additionally, 162 patients with schizophrenia were recruited to complete the final version of the test to test the discriminant validity.Results:(1) The formal Chinese facial Emotion Recognition Test consisted of seven types of emotion including happiness, anger, sadness, disgust, surprise, fear, and calm, each of which had 6 pictures, and a total of 42 pictures formed the final version of the test. The total average difficulty of the test was 0.76, and the total average differentiation was 0.30. (2) The internal consistency and split-half coefficients were 0.77 and 0.72, respectively. The test-retest reliability was 0.81. (3) There was a significant positive correlation between the judgment score of disgust emotion and working memory score and MCCB total score in normal controls ( r=0.572, P<0.01; r=0.426, P=0.028, respectively). Also beside, the total judgment score of all facial emotion categories was positively correlated with the working memory score and the MCCB total score ( r=0.431, P=0.022; r=0.432, P=0.024, respectively). (4) The recognition scores of other emotion categories in schizophrenics were significantly lower than those in normal controls (all P<0.05; the effect value ranged from 0.27 to 0.72), except for calm emotion. The judgment scores of the intensity of aversion, fear, and sadness in schizophrenics were significantly lower than those in normal controls (all P<0.05, the effect value ranged from 0.33 to 0.47). Conclusion:The emotion recognition test based on Chinese face developed in this study has good reliability and validity and can be used as a standardized evaluation tool for the recognition ability of facial emotion category and facial emotion intensity in patients with schizophrenia.

Objective: To establish an intensity-classified Chinese facial emotion image database and provide materials for emotional researches in China. Methods: Firstly, under the guidance of professional director, 22 professional dramatic actors put up seven kinds of emotion, including anger, disgust, fear, sadness, surprise, happy and calm. The process of facial emotional performance of actors were filmed by a high-speed camera. Then we made screen captures according to the intensity of emotion performed by the actors. A total of 814 black-and-white photographs with same size and gray level were made after we removed the irrelevant parts to the facial features. Each kind of emotion contains six levels of intensity scoring from 1 to 6. Totally, 112 healthy volunteers were recruited to evaluate the emotional intensity, pleasure and arousal of all images via a visual scale ranged from 0 to 100. Results: A Chinese face emotional intensity hierarchical picture library was set up, which contained 2 sublibraries. The first library was consisted of 436 images with hierarchical emotional intensity images collected from different performers. The second one was built with 640 images, in which the hierarchical emotional intensity image was collected from same actor/actress. Both image libraries had corresponding scores for intensity, pleasure, and arousal. Furthermore, both exhibited a high degree of internal consistency in reliability analysis (with a Cronbach' s alpha value larger than 0. 9). Conclusion: The present study has established an intensity-classified Chinese facial emotion image database with good recognition degree and psychological measurement attribution, which could provide materials for emotional researches in China.

Objective To analyze CT imaging findings and pathological features of the thymic cyst.Methods The CT findings of 20 cases with thymic cyst confirmed by pathology were analyzed retrospectively.The analysis included the location,shape ,size ,density ,contour, unilocular or multilocular,with or without walls,enhancement and lesion periphery.The pathology results were compared to CT findings.Results All lesions were located in the anterior mediastinum,in which the location of left side in 12 cases,right side in 6 cases,median mediastinum in 2 cases.All lesions had clear border and unilocular,including round shape in 4 cases,oval shape in 8 cases,and irregular shape in 8 cases with triangular shape in 1 case,the size range was 2-6 cm.4 cases had obvious cyst wall.The CT value of the cyst had range of 4-53 HU,with 10 cases less than 10 HU and 10 cases greater than 10 HU.There was no enhancement within the cysts of 20 cases and the cyst wall had enhancement in 4 cases.All cases of pathological findings were confirmed as thymus cyst.Gross sample showed gray red or isabeling.The lesion was cystic in 18 cases,soft stereocyst in 2 cases,bright yellow liquid within the capsule in 10 cases,butter fat in 5 cases,chylomicrons in 3 cases,unilocular in 19 cases and multilocular in 1 case (butter fat).Microscope showed the fibrous capsule wall in all cases,lined with squamous epithelium,ciliated columnar epithelium,monolayer columnar epithelium,in which could be seen normal thymus tissue.The thickness of the wall was no more than 0.5 cm,and multilocular wall smooth,no obvious inflammatory response in the surrounding.Conclusion CT image findings can clearly show the thymic cyst site,shape,size,density and boundaries,unilocular or multilocular,with or without walls.The CT image can reflect pathological features of the thymic cyst,and can provide accurate and reliable information for the clinic.

Objective To explore the inflnence of autologous peripheral blood hematopoietic stem cell transplantation (auto-HSCT) for lymphoma process on the quality of patients blood coagulation.Methods Plasma samples were collected before the conditioning and on day 0,7,14,28,35 follow auto-HSCT from 20 patients.The following parameters were measured:prothrombin time (PT),activated partial thromboplastin time (APTT),fibrinogen (FIB) and D-dimer(D-Di).Results Compared with the values before conditioning,a significant rise in the FIB values was detected on day 7 and day 14 after auto-HSCT,no essentially change in the FIB values was detected on day 21 and day 28 and day 35 after auto-HSCT.Other coagulation parameters investigated(PT.APTT.D-Di) remained essentially unchanged.All of the patients not concurrent thrombotic disease.Conclusion Lymphoma patients with autologous peripheral blood hematopoietic stem cell transplantation appear abnormality in coagulant function.Clinical doctors should concern.