The paper explores the etiology and pathogenesis of chronic fatigue syndrome (CFS), and its diagnosis and treatment with acupuncture and moxibustion based on "body-qi-mind trinity life view". It is believed that CFS refers to the comorbidity of body, qi and mind. In the disease, spleen deficiency in transportation and transformation is the root, resulting in malnutrition of muscles; liver qi stagnation is the pivot, causing dysfunction of three jiao; and disharmony between heart and kidney is crucial, leading to dysfunction of mind. The strategy of treatment with acupuncture and moxibustion is proposed, "relieving general pain of the body as the top priority, regulating qi is the pivot, and housing the mind is the foundation". For relieving general pain of the body, acupuncture is applied to Sanyinjiao (SP6) and Zusanli (ST36) that is the essential prescription to relieve muscular pain. For regulating qi, Waiguan (TE5) and Gongsun (SP4) are selected to promote the pivot of shaoyang and regulate qi movement of three jiao. For housing the mind, acupuncture is delivered at Shenmen (HT7) and moxibustion is applied to Yongquan (KI1), Gaohuang (BL43) and Baihui (GV20) to harmonize the heart and kidney and tranquilize the mind. This intervention mode, i.e. harmonizing among body, qi and mind, and promoting the circulation of qi and blood, is conductive to restoring the body, qi and mind. It provides a new idea to clinical diagnosis and treatment of CFS with acupuncture and moxibustion.
Humans ; Moxibustion ; Fatigue Syndrome, Chronic/physiopathology* ; Acupuncture Therapy ; Qi ; Acupuncture Points ; Male ; Female

Animals ; Archaeal Proteins ; genetics ; metabolism ; Deoxyribonuclease I ; genetics ; metabolism ; Gene Editing ; methods ; Humans ; Natronobacterium ; enzymology ; genetics

Congenital heart disease (CHD) is the most common survivable birth defect in newborns.Pathogenesis of CHD is thought to be associated with environmental and hereditary factors.However,the etiology of most CHD remains unclear.Familial resurgence presents a classic pattern of CHD and data from reviews showed a higher incidence rate in first-degree relatives.Analysis of large multigenerational families could improve the identification of numerous genes and inheritance model in CHD patients.Recent genetic breakthroughs allowed specific evaluation of genetic abnormalities in large families with CHD patients.Next-generation sequencing technologies,genetic linkage analysis and candidate gene analysis have all been applied in the research of family-based CHD.With the development of genetic research technologies, analyses of nuclear famihies or distantly corresponding sporadic cases have generated more progress in CHD studies.Thus, this review will focus on the application of genetic methods in family-based association study of congenital heart disease.

Cardiovascular Diseases ; diagnosis ; therapy ; Child ; Heart Defects, Congenital ; diagnosis ; therapy ; Humans