2.A Review of Balneotherapy Evidences for Diseases of Candidate for Insurance Coverage Based on Randomized Controlled Trials for Rheumatic Diseases
Koichiro OHMURA ; Takahiko HORIUCHI ; Shunji SAKAGUCHI ; Satoru YAMAGUCHI ; Takeshi NAKAMURA ; Yasunori MORI ; Hiroharu KAMIOKA
The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine 2024;87(1):10-10
3.Changes in the Subjective Health of Japanese Medical Workers Owing to Behavioral Restrictions Including Hot Spring Bathing during the COVID-19 Pandemic
Yasunori MORI ; Takeshi NAKAMURA ; Koichiro OHMURA ; Shunji SAKAGUCHI ; Satoru YAMAGUCHI ; Takahiko HORIUCHI ; Hiroharu KAMIOKA
The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine 2024;87(1):11-11
4.Survey on Bathing Habits and Acupuncture and Moxibustion Treatment in Long-Distance Runners─A Survey on Recovery Methods from Fatigue─
Shunji SAKAGUCHI ; Satoru YAMAGUCHI ; Hiroharu KAMIOKA ; Takahiko HORIUCHI ; Koichiro OMURA ; Takeshi NAKAMURA ; Yasunori MORI ; Yasuhisa KANEKO ; Tomokazu KIKUCHI ; Yosuke FUJITA
The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine 2024;87(1):9-9
5.Changes in the Subjective Health of Japanese Medical Workers Owing to Behavioral Restrictions Including Hot Spring Bathing during the COVID-19 Pandemic
Yasunori MORI ; Takeshi NAKAMURA ; Koichiro OHMURA ; Shunji SAKAGUCHI ; Satoru YAMAGUCHI ; Takahiko HORIUCHI ; Hiroharu KAMIOKA
The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine 2023;():2356-
6.Changes in the Subjective Health of Japanese Medical Workers Owing to Behavioral Restrictions Including Hot Spring Bathing during the COVID-19 Pandemic
Yasunori MORI ; Takeshi NAKAMURA ; Koichiro OHMURA ; Shunji SAKAGUCHI ; Satoru YAMAGUCHI ; Takahiko HORIUCHI ; Hiroharu KAMIOKA
The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine 2023;86(2):62-70
7.Changes in the Subjective Health of Medical Workers Owing to Behavioral Restrictions Including Hot Spring Bathing due to the Spread of COVID-19
Yasunori MORI ; Takeshi NAKAMURA ; Koichiro OHMURA ; Shunji SAKAGUCHI ; Satoru YAMAGUCHI ; Takahiko HORIUCHI ; Hiroharu KAMIOKA
The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine 2023;86(1):10-10
8.Distinction between Chronic Enteropathy Associated with the SLCO2A1 Gene and Crohn's Disease.
Shunichi YANAI ; Satoko YAMAGUCHI ; Shotaro NAKAMURA ; Keisuke KAWASAKI ; Yosuke TOYA ; Noriyuki YAMADA ; Makoto EIZUKA ; Noriyuki UESUGI ; Junji UMENO ; Motohiro ESAKI ; Eiko OKIMOTO ; Shunji ISHIHARA ; Tamotsu SUGAI ; Takayuki MATSUMOTO
Gut and Liver 2019;13(1):62-66
BACKGROUND/AIMS: We recently identified recessive mutations in the solute carrier organic anion transporter family member 2A1 gene (SLCO2A1) as causative variants of chronic nonspecific multiple ulcers of the small intestine (chronic enteropathy associated with SLCO2A1, CEAS). The aim of this study was to investigate the gastroduodenal expression of the SLCO2A1 protein in patients with CEAS and Crohn’s disease (CD). METHODS: Immunohistochemical staining for SLCO2A1 was performed with a polyclonal antibody, HPA013742, on gastroduodenal tissues obtained by endoscopic biopsy from four patients with CEAS and 29 patients with CD. RESULTS: The expression of SLCO2A1 was observed in one of four patients (25%) with CEAS and in all 29 patients (100%) with CD (p < 0.001). The three patients with CEAS without SLCO2A1 expression had a homozygous splice-site mutation in SLCO2A1, c.1461+1G>C (exon 7) or c.940+1G>A (exon 10). The remaining one CEAS patient with positive expression of SLCO2A1 had compound heterozygous c.664G>A and c.1807C>T mutations. CONCLUSIONS: Immunohistochemical staining for SLCO2A1 in gastroduodenal tissues obtained by endoscopic biopsy is considered useful for the distinction of CEAS from CD.
Biopsy
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Crohn Disease*
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Humans
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Immunohistochemistry
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Intestine, Small
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Ulcer
Result Analysis
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