Purpose: This study evaluated the effectiveness of a nursing intervention program to promote cancer pain self-management for outpatients using a non-randomized controlled trial. Methods: An intervention group underwent 3 sessions of the intervention program. The primary outcome measured was pain intensity (Japanese brief pain inventory [BPI-J]), and the secondary outcomes included the influence of pain on daily life, the effectiveness of pain relief treatment (BPI-J), quality of life (12-item short-form health survey [SF-12]), self-efficacy (pain self-efficacy questionnaire [PSEQ]), and psychological stability (hospital anxiety and depression scale [HADS]). Results: The data from 19 participants in the control and 16 in the intervention groups were analyzed. A comparison of changes in pain intensity before and after the study showed no statistically significant differences between the 2 groups. However, there was a statistically significant difference in the SF-12 role physical, with a decrease in the control group and an increase in the intervention group ( P=0.020). Conclusion: The only significant difference in the amount of change was found in the SF-12 role physical, and the intervention effect of this program could not be clarified. The reason for this was that the number of subjects was less than the sample size.