With the widespread use of antimicrobial agents, bacterial drug resistance has become an increasingly severe issue, posing significant challenges to global healthcare. Traditional Chinese medicine (TCM) has emerged as a research focus in the field of bacterial resistance due to its broad sources, high safety profile, low toxicity, and antimicrobial mechanisms distinct from those of chemical drugs. Studies have shown that various TCM herbs, such as Scutellaria baicalensis, exert antibacterial effects through multiple pathways, including disrupting the integrity of bacterial cell walls and membranes, inhibiting nucleic acid and protein synthesis, and impairing energy production and metabolism. Additionally, certain TCM herbs, including Scutellaria baicalensis, Coptis chinensis, and Fritillaria thunbergii, can reverse antimicrobial resistance by eliminating resistant plasmids, inhibiting bacterial efflux pump function, and suppressing β-lactamase activity. TCM holds promising potential for antibacterial applications and synergistically reversing antimicrobial resistance, though systematic analyses remain limited. This review summarizes the mechanisms of antibacterial action of TCM and current research on its synergistic use with antimicrobial agents to reverse drug resistance, aiming to provide insights for developing novel TCM-based antimicrobials and addressing bacterial resistance.

OBJECTIVE: To explore the effectiveness of free paraumbilical perforator flaps in repairing skin and soft tissue defects in children. METHODS: Between February 2018 and March 2024, 12 children with skin and soft tissue defects were treated with the free paraumbilical perforator flaps. There were 7 boys and 5 girls with an average age of 6.3 years (range, 2-12 years). The defects located on the upper limbs in 6 cases, lower limbs in 5 cases, and neck in 1 case. The causes of wounds included 7 cases of electrical burns, 1 case of thermal burn, 2 cases of scar release and excision due to scar contraction after burns, 1 case of scar ulcer at the amputation stump after severe burns, and 1 case of skin necrosis after a traffic accident injury. The size of defects after debridement ranged from 7.0 cm×4.0 cm to 18.0 cm×10.0 cm. According to the defect size, 11 cases were repaired with unilateral paraumbilical perforator flaps centered on the umbilicus, among which 3 cases with larger defects were designed as "L"-shaped flaps along the lateral and lower ends of the perforator; the donor sites were directly closed. One case with extensive defect after scar excision and release was repaired with bilateral expanded paraumbilical perforator flaps; the donor sites were repaired with autologous split-thickness skin grafts. The size of flaps ranged from 9.0 cm×4.0 cm to 20.0 cm×11.0 cm. Postoperatively, analgesia and sedation were provided, and the blood supply of the flaps was observed. RESULTS: All operations were successfully completed. The operation time was 4-7 hours, with an average of 5.0 hours. After postoperative analgesia and sedation, the visual analogue scale (VAS) score for pain in all children was less than or equal to 3, and there was no non-cooperation due to pain. All flaps and skin grafts survived completely, and the wounds healed by first intention. Ten children underwent 1-4 times of flap de-fatting, finger separation, and trimming. All children were followed up 6-48 months (mean, 26.6 months). No obvious swelling of the flaps occurred, and the texture was soft. At last follow-up, among the 6 children with upper limb defects, 2 had upper limb function grade Ⅳ and 4 had upper limb function grade Ⅴ according to the Carroll upper limb function assessment method. The 4 children with lower limb defects had no limitation of joint movement. The neck flexion and rotation in the 1 child with neck defect significantly improved when compared with that before operation. The 1 child with residual ulcer at the amputation stump could wear a prosthesis and move without limitation, and no new ulcer occurred. Linear scars were left at the donor sites, and no abdominal wall hernia was formed. CONCLUSION The free paraumbilical perforator flap has abundant blood supply and can be harvested in large size. It can be used to repair skin and soft tissue defects in children and has the advantages of short operation time, minimal injury, high safety, and minimal impact on the growth and development of children.
Humans ; Perforator Flap/transplantation* ; Child ; Male ; Female ; Soft Tissue Injuries/surgery* ; Child, Preschool ; Plastic Surgery Procedures/methods* ; Burns/surgery* ; Umbilicus/surgery* ; Skin Transplantation/methods* ; Skin/injuries* ; Cicatrix/surgery* ; Treatment Outcome

"Weibing" is a fundamental concept in traditional Chinese medicine (TCM), representing a transitional state characterized by diminished self-regulatory abilities without overt physiological or social dysfunction. This perspective delves into the biological foundations and quantifiable markers of Weibing, aiming to establish a research framework for early disease intervention. Here, we propose the "Health Quadrant Classification" system, which divides the state of human body into health, sub-health, disease-susceptible state, and disease. We suggest the disease-susceptible stage emerges as a pivotal point for TCM interventions. To understand the intrinsic dynamics of this state, we propose laboratory and clinical studies utilizing time-series experiments and stress-induced disease susceptibility models. At the molecular level, bio-omics technologies and bioinformatics approaches are highlighted for uncovering intricate changes during disease progression. Furthermore, we discuss the application of mathematical models and artificial intelligence in developing early warning systems to anticipate and avert the transition from health to disease. This approach resonates with TCM's preventive philosophy, emphasizing proactive health maintenance and disease prevention. Ultimately, our perspective underscores the significance of integrating modern scientific methodologies with TCM principles to propel Weibing research and early intervention strategies forward.

Objective:To investigate the etiological distribution of severe community-acquired pneumonia (CAP) in children in Hebei Province.Methods:The nasopharyngeal swab samples and clinical data from 314 children with severe pneumonia were retrospectively analyzed between January 2014 and January 2016.Results:Among the 314 children, 298 (94.94%) showed positive result for pathogens in their nasopharyngeal swab samples, with 246 cases (78.34%) of multiple pathogens, predominantly mixed viruses and bacteria (206 cases, 65.61%). A total of 848 strains of pathogens were detected, including 483 strains (56.96%) of viruses, predominantly respiratory syncytial virus with 97 strains of subtype A and 86 strains of B. Bacteria and atypical pathogens ( Mycoplasma pneumoniae) had 365 strains (43.04%), mainly Streptococcus pneumoniae (220 strains) and Haemophilus influenzae (119 strains). The detection rate of pathogens was higher in children under one year of age ( χ2=21.389, P<0.001). There were no significant differences in different seasons, but the detection rates of respiratory syncytial virus A, respiratory syncytial virus B, and Streptococcus pneumoniae were higher in autumn, winter, and spring, respectively, with statistically significant differences ( χ2=22.205, P<0.001; χ2=37.874, P<0.001; χ2=11.380, P=0.009). Conclusions:Nasopharyngeal swab sample testing in children with severe pneumonia typically shows a coexistence of viral and bacterial pathogens, with detection rates varying among different age groups and seasons. Nasopharyngeal swab sample testing for pathogens provides valuable references for the identification of clinical pathogens.

Public hospitals are important entities in providing medical services in China and main forces in safeguarding people's health.Advancing the quality of medical services in public hospitals and further ensuring the well-being of the public necessitates the enhancement of Party building within public hospitals and the Party's comprehensive leadership over them.Party building guidance is an essential requirement for the development of public hospitals.Concurrently,effective Party building pub-licity is crucial for accelerating Party construction efforts,fostering harmonious doctor-patient relationships,expanding the range of hospital services,and creating a favorable public opinion environment.This paper examines the practices of Party building publicity at Minhang Campus of Guangdong Second Provincial General Hospital,distilling strategies that focus on"highlighting key points,building platforms,and reinforcing links".The strategies provide a reference for the publicity practice of Party build-ing in public hospitals in the new era.

Objective Exploring the career mobility intentions of primary care staff in healthcare consortia to provide a basis for decision-making suggestions on the training and retention decisions of medical staff in the medical alli-ance.Methods To investigate the career mobility intention of medical staff in the medical alliance of Guangdong Second People's Hospital as the survey object.Statistical descriptions of the collected key indicators were con-ducted.Pearson chi-square test and t-test for independent samples were used to analyze the differences between groups,and binary logistic regression with single and multiple factors was used to explore the association between potential factors and the idea of staying at the grassroots level.Results A total of 289 medical staff within the health-care consortium were included,with females being the main group at 63.0％,and the highest proportion of staff un-der 40 years of age at 63.6％.Logistic regression analysis result showed a significant positive association between satisfaction with training effect and thoughts of staying on at the primary level only(P<0.05).Conclusion It is possi-ble to explore the construction of a virtuous circulation mechanism of medical talent resources with the medical asso-ciation construction as the carrier,and promote the orderly flow of manpower within the medical association,so as to achieve the"recruiting,well using,promotion and retaining"medical talent people in primary medical institu-tions.

The National Conference on Medical Emergency Work in 2024 clearly puts forward the need to continu-ously strengthen the construction of emergency medical rescue system and capacity,does a good job in medical treatment of emergencies,and achieves high-quality development of medical emergency work.On the basis of ana-lysing the current situation of medical emergency rescue system construction,taking the construction practice of the first emergency hospital in China in Guangdong Second People's Hospital as an example,it explores the construc-tion of a new model of medical emergency rescue in large public hospitals,including three kinds of capabilities:the ability to transform the combination of level and emergency,the ability to integrate regional medical rescue and coor-dination,and three-dimensional multifunctional emergency rescue capabilities;and two norms:norms for talent training and norms for the management system.Finally,it puts forward suggestions for strengthening the construc-tion of emergency hospitals.

Objective Exploring the career mobility intentions of primary care staff in healthcare consortia to provide a basis for decision-making suggestions on the training and retention decisions of medical staff in the medical alli-ance.Methods To investigate the career mobility intention of medical staff in the medical alliance of Guangdong Second People's Hospital as the survey object.Statistical descriptions of the collected key indicators were con-ducted.Pearson chi-square test and t-test for independent samples were used to analyze the differences between groups,and binary logistic regression with single and multiple factors was used to explore the association between potential factors and the idea of staying at the grassroots level.Results A total of 289 medical staff within the health-care consortium were included,with females being the main group at 63.0％,and the highest proportion of staff un-der 40 years of age at 63.6％.Logistic regression analysis result showed a significant positive association between satisfaction with training effect and thoughts of staying on at the primary level only(P<0.05).Conclusion It is possi-ble to explore the construction of a virtuous circulation mechanism of medical talent resources with the medical asso-ciation construction as the carrier,and promote the orderly flow of manpower within the medical association,so as to achieve the"recruiting,well using,promotion and retaining"medical talent people in primary medical institu-tions.

The National Conference on Medical Emergency Work in 2024 clearly puts forward the need to continu-ously strengthen the construction of emergency medical rescue system and capacity,does a good job in medical treatment of emergencies,and achieves high-quality development of medical emergency work.On the basis of ana-lysing the current situation of medical emergency rescue system construction,taking the construction practice of the first emergency hospital in China in Guangdong Second People's Hospital as an example,it explores the construc-tion of a new model of medical emergency rescue in large public hospitals,including three kinds of capabilities:the ability to transform the combination of level and emergency,the ability to integrate regional medical rescue and coor-dination,and three-dimensional multifunctional emergency rescue capabilities;and two norms:norms for talent training and norms for the management system.Finally,it puts forward suggestions for strengthening the construc-tion of emergency hospitals.

Hospital fire safety management is not only a key aspect of hospital safety management,but also bears the im-portant mission of ensuring the safety of the lives and property of patients within the hospital.With the continuous development of intelligent technology,the fire safety industry is gradually moving towards intelligence,digitization,and networking.This article will combine the practical situation of smart fire protection at Guangdong Second People's Hospital,actively explore new models of smart fire protection construction and application under the new situation,in order to provide reference for major hospitals to build strong fire safety barriers.