Objective:To explore the developmental trajectories of depression and their influencing factors among women conceiving through assisted reproductive technology (ART) from the beginning of the treatment cycle to late pregnancy.Methods:A convenience sampling method was used to recruit 863 women who successfully conceived through ART at the International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University between January 2017 and November 2019. Depressive symptoms were assessed using the Center for Epidemiological Studies Depression Scale (CES-D) at the beginning of the ART cycle (T1), early pregnancy (12-14 weeks, T2), mid-pregnancy (22-24 weeks, T3), and late pregnancy (32-34 weeks, T4). Group-based trajectory model was applied to identify developmental trajectories of antenatal depression, and multivariate Logistic regression was used to analyze influencing factors.Results:The detection rates of depressive symptoms among the 863 women conceiving through ART at T1, T2, T3, and T4 were 29.9% (258/863), 33.3% (287/863), 17.1% (148/863), and 19.8% (171/863), respectively. Three distinct trajectory groups were identified: persistently normal group (51.1%, 441/863), high-then-decreasing group (42.3%, 365/863), and persistently high-depression group (6.6%, 57/863). Multivariate Logistic regression analysis revealed that anxiety symptoms, sleep quality, spouse's age, passive smoking, and pre-pregnancy body mass index were significant influencing factors of the developmental trajectories of antenatal depression ( P<0.05) . Conclusions:Healthcare providers should pay close attention to antenatal depression in women conceiving through ART. Targeted interventions addressing the identified influencing factors should be developed to safeguard maternal and infant health.

Objective:To explore the developmental trajectories of depression and their influencing factors among women conceiving through assisted reproductive technology (ART) from the beginning of the treatment cycle to late pregnancy.Methods:A convenience sampling method was used to recruit 863 women who successfully conceived through ART at the International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University between January 2017 and November 2019. Depressive symptoms were assessed using the Center for Epidemiological Studies Depression Scale (CES-D) at the beginning of the ART cycle (T1), early pregnancy (12-14 weeks, T2), mid-pregnancy (22-24 weeks, T3), and late pregnancy (32-34 weeks, T4). Group-based trajectory model was applied to identify developmental trajectories of antenatal depression, and multivariate Logistic regression was used to analyze influencing factors.Results:The detection rates of depressive symptoms among the 863 women conceiving through ART at T1, T2, T3, and T4 were 29.9% (258/863), 33.3% (287/863), 17.1% (148/863), and 19.8% (171/863), respectively. Three distinct trajectory groups were identified: persistently normal group (51.1%, 441/863), high-then-decreasing group (42.3%, 365/863), and persistently high-depression group (6.6%, 57/863). Multivariate Logistic regression analysis revealed that anxiety symptoms, sleep quality, spouse's age, passive smoking, and pre-pregnancy body mass index were significant influencing factors of the developmental trajectories of antenatal depression ( P<0.05) . Conclusions:Healthcare providers should pay close attention to antenatal depression in women conceiving through ART. Targeted interventions addressing the identified influencing factors should be developed to safeguard maternal and infant health.