Objective To investigate the occurrence of multiple organ dysfunction syndrome(MODS)in patients with basal ganglia hypertensive intracerebral hemorrhage,and analyze its influencing factors.Methods A total of 100 patients with cerebral hemorrhage in our hospital were selected as the research objects.Patients were divided into MODS group and non-MODS group according to whether or not the occurrence of MODS occurred.The clinical data of the two groups were collected.Logistic regression was used to analyze related influencing factors,and ROC curve was used to evaluate the predictive value of Logistic regression model.Results The Logistic regression equation showed that age,time from onset to admission,hematoma volume,Acute Physiology and Chronic Health Status Rating System Ⅱ(APACHEⅡ)score,duration of postoperative mechanical ventilation,fasting plasma glucose(FPG)and delayed surgery were all independent risk factors for the occurrence of MODS in patients with basal ganglia hypertensive cerebral haemorrhage,and GCS score was an independent protective factor for the occurrence of MODS in patients with basal ganglia hypertensive cerebral haemorrhage(all P＜0.05).The ROC curve plotted according to predicted and true values showed that when Log(P)＞3.74,the sensitivity was 84.62%and the specificity was 90.16%;the standard regression coefficients calculated by the partial standardization method yielded that in the Logistic regression analysis.The independent influencing factors in order of importance were APACHEⅡ score,age,FPG,haematoma volume,postoperative mechanical ventilation time,GCS score,time from onset to admission,and delayed surgery.Conclusions Affected by many factors such as age,time from onset to hospital admission,hematoma volume,APACHEⅡ score,postoperative mechanical ventilation time,FPG and so on,patients with cerebral hemorrhage are at risk of MODS.In clinical work,the management of the above factors can be strengthened to reduce the incidence of MODS.

Objective: To examine the association between long-term exposure to ambient PM_2.5 combined with indoor air pollution and handgrip strength among people aged 50 and over. Methods: Data were from the first wave of World Health Organization Study on global AGEing and adult health in China. Ambient annual concentration of PM_2.5 was estimated by using the satellite data we also investigated the use of fuels and chimneys as indoor air pollution. A two-level (individual level and community level) linear model was applied to examine the association between long-term exposure to ambient PM_2.5 combined with indoor air pollution and the handgrip strength. Results: A total of 13 175 individuals aged 50 years and over were included for analysis. The handgrip strength was (26.67±0.54) kg. Ambient PM_2.5 was found to be significantly associated with the risk of decreased handgrip strength. Outdoor PM_2.5 concentration was negatively correlated with handgrip strength (β=-0.23, 95%CI: -0.31 - -0.14) decrease in handgrip strength after adjusting for gender, age, residence, education, household assets, intake of vegetables and fruits, smoking and drinking, physical activity. In rural area, compared to those who used solid fuel, use of clean fuel increased (β=1.41, 95%CI: 0.36-2.46) handgrip strength. But in urban area, we did not find any statistically significant association between the use of clean fuel and handgrip strength (β=0.19, 95%CI: -0.95-1.32). Conclusion This study found that long-term exposure to ambient PM_2.5 combined with indoor air pollution was significantly associated with low handgrip strength among people aged 50 years and over, this suggested that ambient PM_2.5 might serve as one of the risk factors for low physical function seen in the people aged 50 years and over.