Transportation service is an important part of hospital logistics management. In 2023, a tertiary hospital centered on patient service and guided by lean management, launched an intelligent transportation service in the " Didi" mode on the basis of the medical internet of things platform. This practice investigated the status of hospital transportation services and developed an intelligent transportation system that includes three subsystems: task reception and generation, dispatch and command of transportation center, and handheld computer accepting order. At the same time, standardized business processes were developed and transportation service performance evaluations were implemented. This practice had gradually piloted and achieved intelligent management of hospital transportation services. As of December 2023, the hospital had completed a total of about 310 thousand transportation tasks, of which 70% were intelligent system dispatching tasks. The timely delivery service rate had increased from 58% in 2022 to 98% in 2023. This practice had improved the quality and efficiency of transportation services, promoted the high-quality development of hospital logistics management, which could provide references for other hospitals to improve logistics management efficiency.

Objective To investigate the clinical efficacy and related adverse reactions of the combination of camrelizumab with anlotinib as the third-line therapy on advanced non-small cell lung cancer. Methods We retrospectively analyzed the clinical data of 84 patients with advanced non-small cell lung cancer after second-line treatment. According to different treatment methods, 44 patients who received camrelizumab combined with anlotinib were included in the observation group, and 40 patients who received anlotinib alone were included in the control group. The PFS, ORR, DCR and incidence of adverse reactions were analyzed and compared between the two groups. Results The median PFS of the observation group was longer than that of the control group (7.0 vs. 5.6 months, P=0.001). No statistically significant difference was observed in ORR, DCR, the incidence of adverse reactions or the incidence of adverse reactions above grade 3 between two groups (all P > 0.05). Conclusion The clinical efficacy of camrelizumab combined with anlotinib as third-line therapy on advanced non-small cell lung cancer is better than anlotinib alone, and the safety is good.

Objective: To describe the procedure for early corneal epithelial basement membrane(EBM) repair and regeneration in rabbits with corneal penetrating injury. Methods: Forty-two New Zealand white rabbits were divided into modeling 1-, 3-, 5-, 7-, 14-, 21-, and 30-day groups using a random number table method, with 6 rabbits in each group; the right eyes were selected as the experimental eyes.Another 6 New Zealand white rabbits without any treatment were taken as the normal control group.A 2.0-mm trephine was used to ablate a full-thickness button of the central corneal tissue of each rabbit.The corneas were observed by slit lamp biomicroscopy at the respective time points after the trephined injury.Corneal epithelial fluorescein staining was used to evaluate re-epithelialization with Image J software and haze grading was evaluated with the Fantes classification.Hematoxylin-eosin staining was used to observe the healing process of the cornea.Transmission electron microscopy was conducted to assess the regeneration of the EBM and the reconstruction of the cornea.The study protocol was approved by the Ethics Committee of Guangxi Medical University (No.201811031). The use and care of the experimental animals complied with the Statement for the Use of Animals in Ophthalmic and Vision Research. Results: The corneal epithelial fluorescein areas in modeling 1-, 3-, 5-, 7-, and 14-day group were (4.00±0.10), (3.11±0.10), (2.00±0.06), (0.90±0.04) and (0.67±0.03)mm², respectively, with a significant difference among them (F=3 398.88, P<0.01). With the increasing of time after modeling, the corneal epithelium fluorescein area was gradually reduced, showing significant differences between any two groups (all at P<0.05), and the staining was disappeared at 21 and 30 days after modeling.The corneal haze grades were 3.44±0.53, 0.67±0.25, 1.33±0.50, 2.11±0.60, 2.44±0.53, 3.22±0.44 and 3.78±0.44 in modeling 1-, 3-, 5-, 7-, 14-, 21-, and 30-day group, respectively. The corneal opacity score gradually decreased during 1-5 days after modeling and gradually increased during 5-30 days after modeling, with a significant difference among them (F=51.182, P<0.01). Hematoxylin-eosin staining revealed that a fibrin clot formed in the wound area, and a single layer of epithelium covered the area at initial 3 days after modeling, and a large number of fibroblasts and some extracellular matrix were found at 5 days after modeling.At 21 and 30 days after modeling, the collagen fibers were tightly arranged in the anterior stroma.Transmission electron microscopy showed that the wound was filled with irregular collagen fibers and myofibroblasts.The stroma was remodeled at 21 days after modeling, and defective regeneration of the EBM was detected at 21 and 30 days after modeling. Conclusions Corneal fibrosis initiates after corneal penetrating injury in rabbits and gradually aggravates, the EBM regenerates defectively.

Objective:To explore the application value of prognostic nutrition index (PNI) in predicting the quality of life in lung cancer patients undergoing palliative chemotherapy.Methods:Totally 89 lung cancer patients who underwent palliative chemotherapy in the First Affiliated Hospital of Zhengzhou University from June 2014 to June 2017 were selected using convenient sampling, and divided into high-PNI group and low-PNI group according to PNI. The quality of life was compared between the two groups. The Kaplan-Meier method was used to draw survival curves, and Log-Rank test was employed to compare the survival rates of the two groups.Results:Two of the 89 patients died during the study period, and all data of 87 patients were completed, including 56 in the high-PNI group and 31 in the low-PNI group. The overall quality of life score of (72.44±6.49) in the high-PNI group and (68.82±6.01) in the low-PNI group, and the difference was statistically significant ( t=2.557, P<0.05) . The half-year survival rates of the high-PNI and low-PNI groups were 87.50% and 82.14%; the one-year survival rates were 81.02% and 64.28%; and the two-year survival rates were 57.73% and 39.28%, respectively. The differences in survival rates between the two groups were statistically significant (Log-Rank=4.293, P<0.05) . Conclusions:The overall quality of life in lung cancer patients undergoing palliative chemotherapy with low PNI is lower than that of high PNI patients. PNI can be used as a prognostic indicator for lung cancer patients undergoing palliative chemotherapy.

Density of corneal endothelium is commonly used by clinician to evaluate the function of corneal endothelium.The importance of dysfunction of this layer has not been received enough attention in routine clinical works.Recently,dysfunction of corneal endothelium due to the ocular diseases and corneal transplantation has been updated.Different types of glaucoma cause different degrees of damage to the corneal endothelium.Among them,the most serious damage to the corneal endothelium is acute angle closure glaucoma.Different treatment patterns of glaucoma damage to endothelium also have different features.The occurrence frequency,severity of the inflammation and the course of uveitis are the important factors which affect the corneal endothelium.The pathologic changes of pseudoexfoliation syndrome includes hypoxic changes in the anterior chamber,deposition of extracellular matrix in anterior segment and fibroblastic changes of the endothelium.These pathologic changes can decrease the endothelium function and the tolerance of injury.For keratoplasty,corneal immunologic rejection,surgical options,the primary disease and secondary late endothelial failure are the important factors of corneal endothelium dysfunction.Diabetes is a common systemic disease that cause corneal endothelium reserve capacity reduced.The decreasing of Na+/K+-ATPase activity,the accumulation of advanced glycation end products,constant metabolic stress can reduce corneal endothelium wound-healing ability.Recent researches of risk factors for corneal endothelium dysfunction were summarized in this paper to help clinician understand and value assess this element before intraocular surgery.