ObjectiveTo explore the effect of modified Ditan Decoction （涤痰汤） on chronic intermittent hypoxia cognitive function and the potential function mechanism. MethodsTwenty-four Sprague-Dawley （SD） rats were randomly divided into a normal group， a model group， and a modified Ditan Decoction group， with eight rats in each group. Rats in the modified Ditan Decoction group were administered the decoction by gavage at 14.8 ml/（kg·d）， while the normal group and the model group received the same dose of normal saline. Thirty minutes after daily gavage， the rats in all three groups were placed in an intermittent hypoxia chamber. The oxygen concentration for the model group and the modified Ditan Decoction group was adjusted daily for 8 hours using a computer program to establish the model， while the normal group was exposed to the same airflow rate of ambient air. The intervention was continued for 12 weeks to establish a chronic intermittent hypoxia rat model. The Y-maze test was used to evaluate spatial working memory in the rats. Resting-state functional magnetic resonance imaging （rs-fMRI） was performed to detect whole-brain regional homogeneity （ReHo） and seed-based functional connectivity （FC）. Brain regions showing significant differences in rs-fMRI were selected for further analysis. Immunofluorescence was used to detect β-amyloid （Aβ） deposition and the number of ionized calcium-binding adapter molecule 1 （IBA1）-positive microglial cells. Immunohistochemistry was employed to assess the expression of synaptophysin （SYP）， the excitatory synapse marker vesicular glutamate transporter 1 （Vglut1）， and the inhibitory synapse marker vesicular γ-aminobutyric acid transporter （VGAT）. ResultsCompared with the normal group， the model group showed a reduced spontaneous alternation rate in the Y-maze test. The smoothed Z-score standardized regional homogeneity （SzReHo） value in the left entorhinal cortex significantly increased， and the FC value from this seed point to the left basal forebrain significantly reduced. Additionally， the model group exhibited significantly higher Aβ fluorescence intensity and Iba1 positivity in the left entorhinal cortex， decreased expression of SYP， Vglut1， and VGAT， along with an increased Vglut1/VGAT ratio （P＜0.05 or P＜0.01）. Compared to the model group， the modified Ditan Decoction group demonstrated an increased spontaneous alternation rate， a significantly reduced SzReHo value in the left entorhinal cortex， and a significantly increased FC value from this region to the left basal forebrain. Furthermore， this group showed significantly lower Aβ fluorescence intensity and Iba1 positivity in the left entorhinal cortex， increased levels of SYP， Vglut1， and VGAT， and a decreased Vglut1/VGAT ratio （P＜0.05 or P＜0.01）. ConclusionModified Ditan Decoction can reconstruct the projection from the left basal forebrain to the entorhinal cortex in chronic intermittent hypoxia， thereby reducing Aβ aggregation and excessive microglial activation in the left entorhinal cortex. This process improves the excitation/inhibition imbalance caused by synaptic remodeling， ultimately enhancing cognitive function in rats of chronic intermittent hypoxia.

Objective To survey the psychological characteristics of coping style and control capacity of the officers and soldiers in a satellite control center,and to explore its influence factors.Methods Characteristics of coping styles questionnaire and internal control,powerful others and chance scale (internal,powerful others,chance,IPC),were used by cross-sectional study methods in the survey for 502 officers and soldiers.Their basic information was treated by descriptive analysis and frequency analysis.The psychological characteristics of coping styles and psychological control conditions were analyzed by t-test.The psychological characteristics of coping styles and psychological control were investigated by correlation analysis,and the psychological characteristics of coping styles and control related factors were analyzed by multiple linear regression.Results The negative coping and positive coping scores of 502 officers and soldiers were 18.00 + 6.05 and 38.65 ± 5.35 respectively.The negative coping scores were significantly lower than those in normal mode (P＜ 0.01),and the positive coping scores were significantly higher than those in normal mode (P＜0.01).The average scores of IPC were 34.69±4.56,20.46± 6.03 and 20.11 ± 5.41 respectively.The bivariate correlation analysis of the psychological control ability and other factors showed that the negative response of the officers and soldiers had a weak negative correlation with the nature of work,education background,and the job level.The powerful others had a weak negative correlation with gender,and chance had a weak negative correlation with job level and education background.All 5 indexes of the two analyses had certain correlation with the degree of work like and the degree of fatigue.Conclusions The main factors that affect the psychological characteristics of coping style and control capacity are the nature of work,education background,job level,degree of work like and degree of fatigue.The soldiers' continuing education,psychological instruction and consultation should be strengthened to cope with the disproportions on gender,job level and education background.And the psychological coping ability and control ability of officers and soldiers would be improved by enhancing their working interest and alleviating fatigue to gain better psychological health and working capacity and efficiency.

Objective To survey the psychological characteristics of coping style and control capacity of the officers and soldiers in a satellite control center,and to explore its influence factors.Methods Characteristics of coping styles questionnaire and internal control,powerful others and chance scale (internal,powerful others,chance,IPC),were used by cross-sectional study methods in the survey for 502 officers and soldiers.Their basic information was treated by descriptive analysis and frequency analysis.The psychological characteristics of coping styles and psychological control conditions were analyzed by t-test.The psychological characteristics of coping styles and psychological control were investigated by correlation analysis,and the psychological characteristics of coping styles and control related factors were analyzed by multiple linear regression.Results The negative coping and positive coping scores of 502 officers and soldiers were 18.00 + 6.05 and 38.65 ± 5.35 respectively.The negative coping scores were significantly lower than those in normal mode (P＜ 0.01),and the positive coping scores were significantly higher than those in normal mode (P＜0.01).The average scores of IPC were 34.69±4.56,20.46± 6.03 and 20.11 ± 5.41 respectively.The bivariate correlation analysis of the psychological control ability and other factors showed that the negative response of the officers and soldiers had a weak negative correlation with the nature of work,education background,and the job level.The powerful others had a weak negative correlation with gender,and chance had a weak negative correlation with job level and education background.All 5 indexes of the two analyses had certain correlation with the degree of work like and the degree of fatigue.Conclusions The main factors that affect the psychological characteristics of coping style and control capacity are the nature of work,education background,job level,degree of work like and degree of fatigue.The soldiers' continuing education,psychological instruction and consultation should be strengthened to cope with the disproportions on gender,job level and education background.And the psychological coping ability and control ability of officers and soldiers would be improved by enhancing their working interest and alleviating fatigue to gain better psychological health and working capacity and efficiency.